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Perovskite computed tomography imager and three-dimensional reconstruction

Nature Photonics volume 18, pages 1052–1058 (2024)Cite this article

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Abstract

Indirect scintillator computed tomography (CT) imaging suffers from reduced image contrast and high-dose X-ray exposure due to inevitable light losses and multiple energy conversion steps. Here we report a direct lead-halide perovskite CT imager through low-cost spray-coating processes. Detector arrays with 980 μm absorber thickness and <10 nm surface roughness yield uniform X-ray response with detection quantum efficiency of 80% and noise-equivalent dose of 153 pGyair. The perovskite CT imager affords the three-dimensional reconstruction of a tooth under a low effective dose of 5.5 μSv, about two orders of magnitude smaller than dental cone-beam CT, and low-contrast detectability by resolving a 5 Hounsfield unit difference within a 5 mm region of interest.

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Fig. 1: Implementation of a perovskite CT imager.
Fig. 2: Fabrication, uniformity and stability of the spray-coated perovskite thick film.
Fig. 3: Device performance of the perovskite array.
Fig. 4: Performance of the perovskite CT imager.

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All data are available in the article or its Supplementary Information. Correspondence and requests for materials should be addressed to the corresponding author.

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Acknowledgements

We thank D. Li at Norman Bethune Stomatological School of Jilin University for providing the tooth for CT imaging. H.W. acknowledges the National Natural Science Foundation of China (nos. 52173166 and 22105083), the Project of Science and Technology Development Plan of Jilin Province (no. 20230101025JC) and the Xiaomi Young Scholar project. B.Y. acknowledges the Fundamental Research Funds for the Central Universities, JLU and JLUSTIRT (2017TD-06). M.L. acknowledges the National Natural Science Foundation of China (no. 223B2503).

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Authors and Affiliations

  1. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, China

    Yuhong He, Jinmei Song, Mingbian Li, Weijun Li, Xiaopeng Feng, Bai Yang & Haotong Wei

  2. Laboratory for Inorganic Chemistry, Department of Chemistry and Applied Biosciences, ETH Zürich, Zürich, Switzerland

    Kostiantyn Sakhatskyi & Maksym Kovalenko

  3. Empa—Swiss Federal Laboratories for Materials Science and Technology, Dübendorf, Switzerland

    Kostiantyn Sakhatskyi & Maksym Kovalenko

  4. Optical Functional Theragnostic Joint Laboratory of Medicine and Chemistry, The First Hospital of Jilin University, Changchun, China

    Bai Yang & Haotong Wei

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  1. Yuhong He
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Contributions

H.W. conceived and supervised the project. Y.H. prepared the films and detectors, characterized the properties of the films and evaluated the performance of the detectors. J.S. conducted the relevant tests and calculations for DQE and NED. M.L. aided in the device fabrication, conducted the XRD measurements and compiled the tables. M.K. and K.S. contributed to the analysis of device performance. W.L. performed the AFM testing. X.F. assisted with the spray-coating technique. B.Y. commented on the results and provided constructive suggestions. All authors analysed the data. H.W. and Y.H. wrote the paper, with input from all co-authors.

Corresponding author

Correspondence to Haotong Wei.

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Competing interests

H.W., Y.H. and B.Y. are inventors on a Chinese patent application (no. 2023110574872) submitted by Jilin University that covers perovskite CT imagers. The other authors declare no competing interests.

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Nature Photonics thanks Bernd Szyszka and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

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Supplementary information

Supplementary Information

Supplementary Figs. 1–13 and Tables 1 and 2.

Supplementary Video 1

Process of stacking slices to create a 3D image.

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He, Y., Song, J., Li, M. et al. Perovskite computed tomography imager and three-dimensional reconstruction. Nat. Photon. 18, 1052–1058 (2024). https://doi.org/10.1038/s41566-024-01506-y

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