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Interoceptive, feeding-related inputs are integrated by BDNF-expressing neurons in the ventromedial hypothalamus that project to the brainstem and regulate food intake and feeding-associated jaw movements.
Studies in human cell lines and transgenic mouse models show that non-receptor tyrosine-protein kinase TYK2 phosphorylates tau at Tyr29 and thereby promotes its stabilization and accumulation. In mice, knockdown of TYK2 reduced tau levels and attenuated tau neuropathology.
In this Journal Club, Anna Gillespie discusses how the discovery of hippocampal replay during the awake state reshaped our understanding of its role in memory function.
Delineating the neurobiology of pathological anxiety remains challenging. In this Review, Akiki et al. synthesize task-based functional MRI evidence for how vulnerabilities within circuits that mediate acute, distant and sustained threat, reward processing, cognitive control and social processing can lead to its emergence and maintenance.
The influence anatomy exerts on communication between brain regions remains unclear. In this Review, Greaves et al. synthesize how methods of structural connectivity integration constrain inference-based or prediction-based models of directed connectivity to better understand how one brain region exerts control over another.
Through use of the anatomical similarity, structural MRI analytics are now enabling the network organization of individual brains to be mapped. In this Review, Sebenius, Dorfschmidt et al. examine this field of structural MRI similarity network analysis.
