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A cell-autonomous role for border-associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury

ApoE4 is a risk factor for Alzheimerâs disease and vascular dementia. We report that in ApoE4 mice perivascular macrophages are the sole source and effectors of the ApoE4 mediating the neurovascular dysfunction, enhanced white matter damage and cognitive impairment.

Antoine Anfray
Samantha Schaeffer
Costantino Iadecola
Research18 Sept 2024
Nature Neuroscience

Volume: 27, P: 2138-2151
Erratum: Parvalbumin-expressing interneurons coordinate hippocampal network dynamics required for memory consolidation

Nicolette Ognjanovski
Samantha Schaeffer
Sara J. Aton
Amendments and CorrectionsOpen Access06 Jul 2017
Nature Communications

Volume: 8, P: 1
Publisher Correction: Dietary salt promotes cognitive impairment through tau phosphorylation

Giuseppe Faraco
Karin Hochrainer
Costantino Iadecola
Amendments and Corrections14 Jan 2020
Nature

Volume: 578, P: E9
Mapping 123 million neonatal, infant and child deaths between 2000 and 2017

A high-resolution, global atlas of mortality of children under five years of age between 2000 and 2017 highlights subnational geographical inequalities in the distribution, rates and absolute counts of child deaths by age.

Roy Burstein
Nathaniel J. Henry
Simon I. Hay
ResearchOpen Access16 Oct 2019
Nature

Volume: 574, P: 353-358
Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension

Hypertension can lead to cognitive impairment. However, the underlying mechanisms are unclear. Here, the authors show that meningeal T cell-produced interleukin-17 activates border-associated macrophages, affecting neurovascular and cognitive functions in a mouse model of hypertension.

Monica M. Santisteban
Samantha Schaeffer
Costantino Iadecola
Research04 Dec 2023
Nature Neuroscience

Volume: 27, P: 63-77
Dietary salt promotes cognitive impairment through tau phosphorylation

A high-salt diet in mice induces cognitive impairment through a signalling cascade that culminates in increased phosphorylation of tau.

Giuseppe Faraco
Karin Hochrainer
Costantino Iadecola
Research23 Oct 2019
Nature

Volume: 574, P: 686-690
Parvalbumin-expressing interneurons coordinate hippocampal network dynamics required for memory consolidation

Episodic memory consolidation requires activity in hippocampal area CA1. Here the authors report that pharmacogenetic inhibition of CA1 PV+ interneuron firing after fear learning blocks memory consolidation and disrupts associated enhancement in network oscillations and stabilization of functional connectivity patterns.

Nicolette Ognjanovski
Samantha Schaeffer
Sara J. Aton
ResearchOpen Access06 Apr 2017
Nature Communications

Volume: 8, P: 1-14
Revisiting the neurovascular unit

Schaeffer and Iadecola review the anatomical, molecular and functional heterogeneity of the neurovasculature and highlight the coordinated interaction of factors intrinsic and extrinsic to the brain in its dynamic regulation and role in disease.

Samantha Schaeffer
Costantino Iadecola
Reviews05 Aug 2021
Nature Neuroscience

Volume: 24, P: 1198-1209
mGluR5 Modulation of Behavioral and Epileptic Phenotypes in a Mouse Model of Tuberous Sclerosis Complex

Elyza Kelly
Samantha M Schaeffer
Mustafa Sahin
Research05 Dec 2017
Neuropsychopharmacology

Volume: 43, P: 1457-1465

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