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Chikungunya Manifestations and Viremia in Patients Who Presented to the Fever Clinic at Bangkok Hospital for Tropical Diseases During the 2019 Outbreak in Thailand
Imad, H.A.; Phadungsombat, J.; Nakayama, E.E.; Kludkleeb, S.; Matsee, W.; Ponam, T.; Suzuki, K.; Leaungwutiwong, P.; Piyaphanee, W.; Phumratanaprapin, W.; Shioda, T. Chikungunya Manifestations and Viremia in Patients WhoPresented to the Fever Clinic at Bangkok Hospital for Tropical Diseases during the 2019 Outbreak in Thailand. Trop. Med. Infect. Dis.2021, 6, 12.
Imad, H.A.; Phadungsombat, J.; Nakayama, E.E.; Kludkleeb, S.; Matsee, W.; Ponam, T.; Suzuki, K.; Leaungwutiwong, P.; Piyaphanee, W.; Phumratanaprapin, W.; Shioda, T. Chikungunya Manifestations and Viremia in Patients WhoPresented to the Fever Clinic at Bangkok Hospital for Tropical Diseases during the 2019 Outbreak in Thailand. Trop. Med. Infect. Dis. 2021, 6, 12.
Imad, H.A.; Phadungsombat, J.; Nakayama, E.E.; Kludkleeb, S.; Matsee, W.; Ponam, T.; Suzuki, K.; Leaungwutiwong, P.; Piyaphanee, W.; Phumratanaprapin, W.; Shioda, T. Chikungunya Manifestations and Viremia in Patients WhoPresented to the Fever Clinic at Bangkok Hospital for Tropical Diseases during the 2019 Outbreak in Thailand. Trop. Med. Infect. Dis.2021, 6, 12.
Imad, H.A.; Phadungsombat, J.; Nakayama, E.E.; Kludkleeb, S.; Matsee, W.; Ponam, T.; Suzuki, K.; Leaungwutiwong, P.; Piyaphanee, W.; Phumratanaprapin, W.; Shioda, T. Chikungunya Manifestations and Viremia in Patients WhoPresented to the Fever Clinic at Bangkok Hospital for Tropical Diseases during the 2019 Outbreak in Thailand. Trop. Med. Infect. Dis. 2021, 6, 12.
Abstract
Chikungunya virus is an Alphavirus belonging to the family Togaviridae that is transmitted to humans by an infected Aedes mosquito. Patients develop fever, inflammatory arthritis, and rash during the acute stage of infection. Although the illness is self-limiting, atypical and severe cases are not uncommon, and 60% may develop chronic symptoms that persist for months or even for longer durations. Having a distinct periodical epidemiologic outbreak pattern, chikungunya virus reappeared in Thailand in December 2018. Here, we describe a cohort of acute chikungunya patients who had presented to the Bangkok Hospital for Tropical Diseases during October 2019. Infection was confirmed by real-time RT-PCR using serum collected at presentation to the Fever Clinic. Other possible acute febrile illnesses such as influenza, dengue, and malaria were excluded. We explored the sequence of clinical manifestations at presentation during the acute phase and associated the viral load with the clinical findings. Most of the patients were healthy individuals in their forties. Fever and arthralgia were the predominant clinical manifestations found in this patient cohort, with a small proportion of patients with systemic symptoms. Higher viral loads were associated with arthralgia, and arthralgia with the involvement of the large joints was more common in female patients
Keywords
Alphavirus; chikungunya virus; East Central South African lineage; Indian Ocean sub-lineage; acute febrile illness; viremia; arthritides
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.