order information
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Order-preserving encryption (OPE) that preserves the numerical ordering of plaintexts is one of the promising solutions of cloud security. In 2013, an ideally secure OPE, which reveals no additional information except for the order of underlying plaintexts, was proposed, along with the notion (mutable encryption) that ciphertexts can be changed. Unfortunately, even the ideally secure OPE can be vulnerable by inferring the underlying frequency of repeated plaintexts. To solve this problem, in 2015, Kerschbaum designed a frequency-hiding OPE (FH-OPE) scheme based on the notion of a randomized order under the strengthened security model. Later, Maffei et al. has shown that Kerschbaum’s model is imprecise, which means no such OPE scheme can exist. Moreover, they provided a new FH-OPE scheme under the corrected security model. However, their scheme requires the order information of all the encrypted plaintexts as an input; therefore, it causes relatively high overhead during encryption. In this work, we propose a more efficient FH-OPE based on Maffei et al.’ s security model and also present an improved update algorithm suitable for duplicate plaintexts.

Batch process generally has varying dynamic characteristic that causes low fault detection rate and high false alarm rate, and it is necessary and urgent to monitor batch process. This paper proposes a global enhanced multiple neighborhoods preserving embedding based fault detection strategy for dynamic batch process. Firstly, the angle neighbor is defined and selected to compensate for the insufficient expression for the spatial similarity of samples only by using the distance neighbor, and the time neighbor is introduced to describe the time correlations between samples. These three types of neighbors can fully characterize the similarity of the samples in time and space. Secondly, considering the minimum reconstruction error and the order information of three types of neighbors, an enhanced objective function is constructed to prevent the loss of order information when neighborhood preserving embedding (NPE) calculates the reconstruction weights. Furthermore, the enhanced objective function and a global objective function are organically combined to extract both global and local features, to describe process dynamics and visualize process data in a low-dimensional space. Finally, a monitoring index based on support vector data description is constructed to eliminate adverse effects of non-Gaussian data for monitoring performance. The advantages of the proposed method over principal component analysis, neighborhood preserving embedding, dynamic principal component analysis and time NPE are demonstrated by a numerical example and the penicillin fermentation process simulation.

Abstract Background It is essential for radiologists to communicate actionable findings to the referring clinicians reliably. Natural language processing (NLP) has been shown to help identify free-text radiology reports including actionable findings. However, the application of recent deep learning techniques to radiology reports, which can improve the detection performance, has not been thoroughly examined. Moreover, free-text that clinicians input in the ordering form (order information) has seldom been used to identify actionable reports. This study aims to evaluate the benefits of two new approaches: (1) bidirectional encoder representations from transformers (BERT), a recent deep learning architecture in NLP, and (2) using order information in addition to radiology reports. Methods We performed a binary classification to distinguish actionable reports (i.e., radiology reports tagged as actionable in actual radiological practice) from non-actionable ones (those without an actionable tag). 90,923 Japanese radiology reports in our hospital were used, of which 788 (0.87%) were actionable. We evaluated four methods, statistical machine learning with logistic regression (LR) and with gradient boosting decision tree (GBDT), and deep learning with a bidirectional long short-term memory (LSTM) model and a publicly available Japanese BERT model. Each method was used with two different inputs, radiology reports alone and pairs of order information and radiology reports. Thus, eight experiments were conducted to examine the performance. Results Without order information, BERT achieved the highest area under the precision-recall curve (AUPRC) of 0.5138, which showed a statistically significant improvement over LR, GBDT, and LSTM, and the highest area under the receiver operating characteristic curve (AUROC) of 0.9516. Simply coupling the order information with the radiology reports slightly increased the AUPRC of BERT but did not lead to a statistically significant improvement. This may be due to the complexity of clinical decisions made by radiologists. Conclusions BERT was assumed to be useful to detect actionable reports. More sophisticated methods are required to use order information effectively.

Abstract Long non-coding RNAs (lncRNAs) are a class of RNA molecules with more than 200 nucleotides. A growing amount of evidence reveals that subcellular localization of lncRNAs can provide valuable insights into their biological functions. Existing computational methods for predicting lncRNA subcellular localization use k-mer features to encode lncRNA sequences. However, the sequence order information is lost by using only k-mer features. We proposed a deep learning framework, DeepLncLoc, to predict lncRNA subcellular localization. In DeepLncLoc, we introduced a new subsequence embedding method that keeps the order information of lncRNA sequences. The subsequence embedding method first divides a sequence into some consecutive subsequences and then extracts the patterns of each subsequence, last combines these patterns to obtain a complete representation of the lncRNA sequence. After that, a text convolutional neural network is employed to learn high-level features and perform the prediction task. Compared with traditional machine learning models, popular representation methods and existing predictors, DeepLncLoc achieved better performance, which shows that DeepLncLoc could effectively predict lncRNA subcellular localization. Our study not only presented a novel computational model for predicting lncRNA subcellular localization but also introduced a new subsequence embedding method which is expected to be applied in other sequence-based prediction tasks. The DeepLncLoc web server is freely accessible at http://bioinformatics.csu.edu.cn/DeepLncLoc/, and source code and datasets can be downloaded from https://github.com/CSUBioGroup/DeepLncLoc.