methodological framework
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The purpose of this article is to present a psychological hermeneutic triangulation model of emotional intelligence in the course of individual’s life fulfillment. In this context, the methodological framework and psychotechnical tools of positive psychotherapy contribute to the explication of the axiological potential of the emotional intelligence in three modes of realization: internal, external and integrative through the bodily sensation and emotional competence and understanding, interpretation and hermeneutic circle mechanisms. Application of positive psychotherapy at the empirical stage of the study has resulted in a training program for the development of emotional intelligence in the areas of individual’s life fulfillment relevant for the participants, as well as through individual consultations. The article presents evidence of the effectiveness of a prolonged formative experiment on the development of emotional intelligence by means of positive psychotherapy, which helped verify the author’s theoretical model. Keywords: emotional intelligence, positive psychotherapy, training, bodily sensation, emotional competence, mode of individual’s life fulfillment

E-commerce is always more diffused as a selling channel around the whole world market, and its importance has increased and continues to increase with the COVID-19 pandemic emergency. It provides enterprises a lot of opportunities, as the importance of physical stores to sell goods is bypassed. However, it has also changed the role of logistics in the supply chain. For this reason, this work aims to identify the main logistics research areas related to e-commerce implementation and the factors and key performance indicators, which should be taken into account for each logistics research area, with particular attention to sustainable aspects. For doing this, a structured and comprehensive literature analysis is carried out. Keywords associated with e-commerce and logistics areas are matched to identify the most interesting works related to its implementation. From the analysis, five main research areas are identified: Supply Chain Network Design (SCND); Outbound Logistics (OL); Reverse Logistics (RL); Warehousing (WR); and IT and data management (E-IT). For each area, key factors, strategies and performance indicators have been identified. Finally, a methodological framework that summarizes the results of the analysis is presented; this is a useful tool for managers to implement or expand their e-commerce business. Many works are focused on one research area, carrying out critical factors, models, and methods to implement that topic. Instead, the methodological framework presented here summarizes multiple research areas from a logistic point of view, identifying for each one input and output variables and how they influence each other.

Multibeam echosounders (MBES) have become a valuable tool for underwater floor mapping. However, MBES data are often loaded with different measurement errors. This study presents a new user-friendly and methodological semi-automatic approach of point cloud post-processing error removal. The St. Anthony Channel (Croatia) was selected as the research area because it is regarded as one of the most demanding sea or river passages in the world and it is protected as a significant landscape by the Šibenik-Knin County. The two main objectives of this study, conducted within the Interreg Italy–Croatia PEPSEA project, were to: (a) propose a methodological framework that would enable the easier and user-friendly identification and removal of the errors in MBES data; (b) create a high-resolution integral model (MBES and UAV data) of the St. Anthony Channel for maritime safety and tourism promotion purposes. A hydrographic survey of the channel was carried out using WASSP S3 MBES while UAV photogrammetry was performed using Matrice 210 RTK V2. The proposed semi-automatic post-processing of the MBES acquired point cloud was completed in the Open Source CloudCompare software following five steps in which various point filtering methods were used. The reduction percentage in points after the denoising process was 14.11%. Our results provided: (a) a new user-friendly methodological framework for MBES point filtering; (b) a detailed bathymetric map of the St. Anthony Channel with a spatial resolution of 50 cm; and (c) the first integral (MBES and UAV) high-resolution model of the St. Anthony Channel. The generated models can primarily be used for maritime safety and tourism promotion purposes. In future research, ground-truthing methods (e.g., ROVs) will be used to validate the generated models.

Combining multiple therapeutic strategies in NRAS/BRAF mutant melanoma, namely MEK/BRAF kinase inhibitors, immune checkpoint inhibitors, and targeted immunotherapies, may offer an improved survival benefit by overcoming limitations associated with any individual therapy. Still, optimal combination, order, and timing of administration remains under investigation. Here, we measure how MEK inhibition alters anti-tumor immunity by utilizing quantitative immunopeptidomics to profile changes the peptide MHC (pMHC) repertoire. These data reveal a collection of tumor antigens whose presentation levels are selectively augmented following therapy, including several epitopes present at over 1000 copies-per-cell. We leveraged the tunable abundance of MEKi-modulated antigens by targeting 4 epitopes with pMHC-specific T cell engagers and antibody drug conjugates, enhancing cell killing in tumor cells following MEK inhibition. These results highlight drug treatment as a means to enhance immunotherapy efficacy by targeting specific upregulated pMHCs and provide a methodological framework for identifying, quantifying, and therapeutically targeting additional epitopes of interest.

Abstract The article analyzes how the leaders and the candidates of the main parties in Romania built a European field of power and subject positions in the context of the 2019 European elections. We adopt the premise that the (re) positioning of these politicians towards the EU is part of their ongoing strategies of (de) legitimization. In this respect, the study focuses on how they assign themselves a “European authority” in relation to audiences through their positioning as actors in the field. On the basis of a mainly critically discursive methodological framework, we analyze a corpus consisting of electoral messages on Facebook. The research reveals the ways in which the political actors build claims, representations and positionings about the EU through naturalizing (a) symmetric relations, statuses, and symbolic power hierarchies.

Background: Aquatic exercise is among the most common physical activity modalities performed by people with disabilities. Objective: The present paper reviews currently-available research on aquatic therapy (AT) for persons with neuromuscular diseases (NMD). Methods: A scoping review of the existing literature was conducted on PubMed, Embase, Medline, Scopus, Web of Science, SPORTdiscus, CINAHL and Lilacs from the earliest date available until October 2020. It follows the methodological framework for conducting a scoping review proposed by the Joanna Briggs Institute. Results: A total of 28 articles were analyzed and the study parameters grouped by the topography of NMD; most of the studies (n = 16) addressed myopathies. A considerable increase in the number of studies was found over time, and heterogeneity was identified across and within AT interventions for persons with NMD; hence, to allow more effective interpretation of study results, there is a need to standardize the fundamental parameters and procedures for aquatic therapy. Conclusions: This scoping review provides a comprehensive outline of available literature; the findings could serve as a starting point for clinical studies on the effects of AT on persons with NMD, and encourage a more coherent approach to their design.