The value chain of agri-food is radically changed due the fact that consumers, as well as various players in the agro-logistics chain, seek for increased and trustful food safety. Given the specific characteristics of the agri-food supply chain, having numerous origin points, several aggregations hubs at different levels and then again numerous points of sales, the need of a holistic approach in collecting, forwarding and interpreting data in an interoperable way is a dire need. In this chapter, the authors present the architecture of the traceability platform KalaΘosTM and its IoT management module called, GP CoreIoTTM. The KalaΘos infrastructure includes a network of sensors devices at farms, equipment, trucks, aggregation, processing, and logistics facilities, connected to a network of LoRa gateways. Its open architecture focuses on semantic and syntactic interoperability approaches for joint exploitation of data collected and managed by other systems with similar aims and scope.