load distribution
Recently Published Documents

The blade load distributions reflect the working characteristics of centrifugal impellers, and the vortexes in the impeller channel affect the blade load distribution, but the mechanism of this phenomenon is still unclear. In this study, particle image velocimetry (PIV) was adopted to clarify the correlation between the internal flow pattern and the blade load distribution. The internal flow pattern and the blade load distribution were presented under different working conditions to study the influence of the internal flow pattern on the blade load. Results showed that the vortexes in the flow channel redistributed the blade load. The clockwise vortex made the position of the maximum blade load closer to the outlet, while the counterclockwise vortex had the opposite effect. Meanwhile, the vortexes caused the blade load distribution to be steeper, which reduced energy conversion efficiency. Moreover, the mean absolute flow angle was introduced to explain the mechanism of the effects of vortexes on blade load. The results can be used as a theoretical basis for the design of high-performance impellers.

The intervertebral disc (IVD) has long been known as a mechanical structure responsible for spinal flexibility and load distribution, while its dysfunction is a frequent source of pain and disability. In recent years, multiple signaling pathways contributing to the regulation of the IVD homeostasis in health and disease have been discovered. At the same time, crosstalk of the IVD with adjacent tissues, immune cells, nerve cells and systemic mediators has been identified as an essential mechanism of degeneration and repair. Such discoveries open the door for the design of new therapeutic and diagnostic targets. This Disc Biology Special Issue provides an abstract of cutting-edge findings in terms of tissue regulation, therapeutic intervention and preclinical models, which will help to improve the management of IVD disorders.