This chapter catalogues the working experiences of the architects AHR and their design team and their clients, the Royal College of Physicians, for the design and construction of The Spine, their new Northern HQ, in Liverpool, UK. This iconic building opened in early 2021 and optimistically reflects the ethos and values of the college, and it is set to become one of the healthiest buildings in the world. It will describe and explain the biophilic and salutogenic design construction processes taken by the design team, from commissioning to completion. The main objective for the college when commissioning AHR architects to design their new building was to significantly expand their facilities and to reflect their standing in the world of medicine. So, the AHR design team endeavored to help them attain their goal of a WELL Platinum and the Building Research Establishments Environmental Assessment Methods (BREEAM) Outstanding certification.