sustained effort
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Tackling grand challenges requires coordination and sustained effort among multiple organizations and stakeholders. Yet research on stakeholder theory has been conceptually constrained in capturing this complexity: existing accounts tend to focus either on dyadic level firm–stakeholder ties or on stakeholder networks within which the focal organization is embedded. We suggest that addressing grand challenges requires a more generative conceptualization of organizations and their constituents as stakeholder systems. Using the metaphor of ballet and insights from dance theory, we highlight four defining dimensions of stakeholder systems (two structural and two dyadic); we proceed to offer a dynamic model of how those dimensions may interact and coevolve. Our metaphor and resulting theory of stakeholder systems are thereby well equipped to incorporate the complexity of tackling grand challenges, where many contemporary stakeholder arrangements are oriented around issues rather than firms.

(1) Background: Microtubule depolymerizing agents (MDAs) are commonly used for cancer treatment. However, the therapeutic use of such microtubule inhibitors is limited by their toxicity and the emergence of resistance. Thus, there is still a sustained effort to develop new MDAs. During the characterization of such agents, mainly through in vitro analyses using purified tubulin and cytotoxicity assays, quantitative comparisons are mandatory. The relationship between the effect of the drugs on purified tubulin and on cell viability are not always direct. (2) Methods: We have recently developed a cell-based assay that quantifies the cellular microtubule content. In this study, we have conducted a systematic comparative analysis of the effect of four well-characterized MDAs on the kinetics of in vitro tubulin assembly, on the cellular microtubule content (using our recently developed assay) and on cell viability. (3) Conclusions: These assays gave complementary results. Additionally, we found that the drugs’ effect on in vitro tubulin polymerization is not completely predictive of their relative cytotoxicity. Their effect on the cellular microtubule content, however, is closely related to their effect on cell viability. In conclusion, the assay we have recently developed can bridge the gap between in vitro tubulin assays and cell viability assays.

AbstractThis article presents a Deweyan reading of the processes of critique, experimentation, and reform that took hold of a minority of psychiatric institutions in Western Europe during the nineteen-sixties and seventies, under the influence of the so-called Italian and British antipsychiatry movements. Framed within a specific understanding of the sixties, the article examines these complex theoretical and institutional operations against the background of John Dewey’s idea of democracy, which it interprets, above all else, as the constant provision of material, intellectual, and human resources for the people to directly transform their environment and themselves in increasingly complex and creative ways. After acknowledging the historical and conceptual discontinuities that exist between these two autonomous bodies of knowledge, the first section presents a summary of Dewey’s philosophy. Next the article sheds light on Basaglia’s and Laing’s antipsychiatric projects by interpreting them as a sustained effort to distinguish between schizophrenia as a first and a second disease, an epistemological search in the midst of which each of them ended up creating new institutions that necessarily embarked their inmates on a radical process of Deweyan growth. The key role of the sixties counterculture is emphasized at this point, and examples from Gorizia’s and Trieste’s asylums, as well as British community households, are read in terms of Basaglia’s and Laing’s negative and affirmative dialectics, respectively. Finally, in the last two sections, the article argues that antipsychiatry’s analysis of psychotic behavior significantly enlarges Dewey’s understanding of the circuit of growth and experience, and that Dewey’s ideas of growth and experience provided, in turn, a missing criterion for defining mental health and deriving coherent therapeutic and institutional concretions.

To raise the superconducting-transition temperature (Tc) has been the driving force for the long-sustained effort in superconductivity research. Recent progress in hydrides with Tcs up to 287 K under pressure of 267 GPa has heralded a new era of room temperature superconductivity (RTS) with immense technological promise. Indeed, RTS will lift the temperature barrier for the ubiquitous application of superconductivity. Unfortunately, formidable pressure is required to attain such high Tcs. The most effective relief to this impasse is to remove the pressure needed while retaining the pressure-induced Tc without pressure. Here, we show such a possibility in the pure and doped high-temperature superconductor (HTS) FeSe by retaining, at ambient pressure via pressure quenching (PQ), its Tc up to 37 K (quadrupling that of a pristine FeSe at ambient) and other pressure-induced phases. We have also observed that some phases remain stable without pressure at up to 300 K and for at least 7 d. The observations are in qualitative agreement with our ab initio simulations using the solid-state nudged elastic band (SSNEB) method. We strongly believe that the PQ technique developed here can be adapted to the RTS hydrides and other materials of value with minimal effort.

Abstract Background Coronavirus disease 2019 (COVID-19) has no confirmed specific treatments. However, there might be in vitro and early clinical data as well as evidence from severe acute respiratory syndrome and Middle Eastern respiratory syndrome that could inform clinicians and researchers. This systematic review aims to create priorities for future research of drugs repurposed for COVID-19. Methods This systematic review will include in vitro, animal, and clinical studies evaluating the efficacy of a list of 34 specific compounds and 4 groups of drugs identified in a previous scoping review. Studies will be identified both from traditional literature databases and pre-print servers. Outcomes assessed will include time to clinical improvement, time to viral clearance, mortality, length of hospital stay, and proportions transferred to the intensive care unit and intubated, respectively. We will use the GRADE methodology to assess the quality of the evidence. Discussion The challenge posed by COVID-19 requires not just a rapid review of drugs that can be repurposed but also a sustained effort to integrate new evidence into a living systematic review. Trial registration PROSPERO 2020 CRD42020175648

Back-channel contacts led in early 1975 to an IRA ceasefire that lasted for much of that year. IRA representatives and British government officials now embarked for the first time since the outbreak of the Troubles on a series of regular face-to-face meetings aimed at negotiating an end to the conflict. The venue was the house of intermediary Brendan Duddy in Derry. Chapter Five offers a new explanation for the failure of a serious and sustained effort to bring a negotiated end to the conflict during the IRA ceasefire of 1975. It outlines the mutual understanding and goodwill that developed in the course of these secret talks. It shows the extent of the intra-party divisions that hindered compromise and explains how they contributed to the collapse of the ceasefire and the breakdown of talks. It argues that, in many important respects, this process was a precursor to the peace settlement of the 1990s and shared many of its key features, including a willingness by the IRA to compromise on its core ideological positions and to contemplate alternatives to Irish reunification.

Introduction: This study aims to understand the dynamics of insurance as a risk management tool for natural disasters in India. It further explores different strategies and programs for disaster insurance adopted by the Indian government and highlights these initiatives' gaps. Methods: The authors conducted both offline and online desk reviews to understand the dynamics of insurance mechanisms and government strategies. They conducted a narrative review of existing literature, including peer-reviewed articles, thematic books, and government and non-governmental reports from diverse sources. Results: The review clearly shows that despite the various types of natural disasters the country faces, the coverage of disaster insurance in India remains low. It outlines the importance of insurance as a risk management tool, especially for the most vulnerable sections of society living in rural parts. The review further highlights the benefits of different government schemes and strategies while at the same time highlighting the gaps in these schemes. Conclusion: The review calls for an urgent and sustained effort to increase the number of individuals insured against natural disasters in the country by addressing the policy shortcomings and engaging with the communities and the private sector to understand their respective needs. The review also underlines the importance of creating awareness regarding disaster insurance among the wider population. Furthermore, it calls for a comprehensive disaster management plan with insurance as one of its pillars.