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ABSTRACT Introduction: Brief introduction: Taekwondo is a sport that integrates explosive power and reaction speed. The reaction speed of the athletes has a direct bearing on the result of the competition. Objective: To improve the reaction time effect of athletes. Methods: Forty-one Taekwondo team athletes were selected as the research subjects. Then, the training methods were introduced, and special technology using an emg tester and a synchronous camera system was implemented to analyze the earliest emg signals and the moment of the hit, the time from signal emergence to the emg reaction for reaction time, and from signal emergence to hit for the total time. Results: The average score of the 41 athletes before the test was 0.282673,with standard deviation of 0.0377349 and standard error of 0.0058932. The average score, standard deviation, and standard error of the 41 athletes after small training were 0.28217, 0.037744 and 0.005895. Conclusions: From the test results of the three training modes, the small training mode had a significant impact on the reaction time of Taekwondo athletes, while the medium and large training modes did not have significant effects. The results show that a small amount of training is best and plays a significant role in improving the reaction of an athlete. Level of evidence II; Therapeutic studies - investigation of treatment results.

Background The expected value of sample information (EVSI) calculates the value of collecting additional information through a research study with a given design. However, standard EVSI analyses do not account for the slow and often incomplete implementation of the treatment recommendations that follow research. Thus, standard EVSI analyses do not correctly capture the value of the study. Previous research has developed measures to calculate the research value while adjusting for implementation challenges, but estimating these measures is a challenge. Methods Based on a method that assumes the implementation level is related to the strength of evidence in favor of the treatment, 2 implementation-adjusted EVSI calculation methods are developed. These novel methods circumvent the need for analytical calculations, which were restricted to settings in which normality could be assumed. The first method developed in this article uses computationally demanding nested simulations, based on the definition of the implementation-adjusted EVSI. The second method is based on adapting the moment matching method, a recently developed efficient EVSI computation method, to adjust for imperfect implementation. The implementation-adjusted EVSI is then calculated with the 2 methods across 3 examples. Results The maximum difference between the 2 methods is at most 6% in all examples. The efficient computation method is between 6 and 60 times faster than the nested simulation method in this case study and could be used in practice. Conclusions This article permits the calculation of an implementation-adjusted EVSI using realistic assumptions. The efficient estimation method is accurate and can estimate the implementation-adjusted EVSI in practice. By adapting standard EVSI estimation methods, adjustments for imperfect implementation can be made with the same computational cost as a standard EVSI analysis. Highlights Standard expected value of sample information (EVSI) analyses do not account for the fact that treatment implementation following research is often slow and incomplete, meaning they incorrectly capture the value of the study. Two methods, based on nested Monte Carlo sampling and the moment matching EVSI calculation method, are developed to adjust EVSI calculations for imperfect implementation when the speed and level of the implementation of a new treatment depends on the strength of evidence in favor of the treatment. The 2 methods we develop provide similar estimates for the implementation-adjusted EVSI. Our methods extend current EVSI calculation algorithms and thus require limited additional computational complexity.

Artificial intelligence (AI) is one of the most important technologies in the world today. In the future, intelligent machines will replace or enhance human capabilities in many areas. Artificial Intelligence is impacting the future of virtually every industry and every human being. AI has acted as the main driver of emerging technologies like big data, robotics, and IoT, and it will continue to act as a technological innovator for the foreseeable future. AI is simply the study of how to make computer do things which at the moment people do the better. There are many ways to define AI, but one simple definition is “intelligence demonstrated by machines”. Primary goal of AI is to improve computer behaviour so that it can be called intelligent. AI is ubiquitous and is not only limited to computer science but has evolved to include other areas like health, security, education, music, art, and business application. This paper gives an overview of how the AI actually works, its scopes , the different applications of AI, its advantages and disadvantages and many more topics which will give a clear understanding inspite of the boundlessness of AI.

Colorectal cancer (CRC) is the third most common cancer in the world and represents the third most deadly tumor worldwide. About 15–25% of patients present metastasis in the moment of diagnosis, the liver being the most common site of metastization. Therefore, the development of new therapeutic agents is needed, to improve the patients’ prognosis. Amino acids transporters, LAT1 and ASCT2, are described as upregulated in CRC, being associated with a poor prognosis. Extracellular vesicles have emerged as key players in cell-to-cell communication due to their ability to transfer biomolecules between cells, with a phenotypic impact on the recipient cells. Thus, this study analyzes the presence of LAT1 and ASCT2 mRNAs in CRC-EVs and evaluates their role in phenotype modulation in a panel of four recipient cell lines (HCA-7, HEPG-2, SK-HEP-1, HKC-8). We found that HCT 116-EVs carry LAT1, ASCT2 and other oncogenic mRNAs being taken up by recipient cells. Moreover, the HCT 116-EVs’ internalization was associated with the increase of LAT1 mRNA in SK-HEP-1 cells. We also observed that HCT 116-EVs induce a higher cell migration capacity and proliferation of SK-HEP-1 and HKC-8 cells. The present study supports the LAT1-EVs’ mRNA involvement in cell phenotype modulation, conferring advantages in cell migration and proliferation.

The purpose of this creation is to develop, introduce, the culture or custom of karo marriage in the form of painting. And can implement it in the form of painting so that it can be enjoyed by the community without having to wait for the moment of the Karo traditional wedding directly. The method of creating this work uses the Exploration method, including; idea exploration, concept exploration, form exploration, media exploration, technical exploration, aesthetic exploration and data analysis, namely primary data and secondary data. The embodiment of this work is in the form of paintings with canvas as the main media with sizes ranging from 70 X 90 Cm, 100 X 100 Cm, to 150 x 150 Cm. The creation of this painting is to implement and tell stories about the Karo traditional wedding in North Sumatra. It is hoped that this painting can introduce and become an educational medium for audiences who do not know this custom or culture.  Keywords: Wedding, Karo Culture, Creation Idea, Art, Painting

Since psoriasis (PsO) is a chronic inflammatory disease, patients may experience a drug failure also with very effective drugs (i.e., secukinumab) and, consequently, dermatologists have two therapeutic options: switching or perform a combination therapy (rescue therapy) to save the drug that had decreased its efficacy. At the moment no studies focused on combination/rescue therapy of secukinumab, so we performed a 52-weeks multicenter retrospective observational study that involved 40 subjects with plaque psoriasis that experienced a secondary failure and were treated with combination therapy (ciclosporin (n = 11), MTX (n = 15), NB-UVB (n = 7) and apremilast (n = 7)). After 16 weeks of rescue/combination therapy, PASI and a DLQI varied respectively from 8 [7.0–9.0] and 13 [12.0–15.0], to 3 [2.8–4.0] and 3 [2.0–3.3]), suggesting a significant improvement of daily functionality and quality of life. Results were maintained at 52 weeks. No side effects were experienced during the study. Secukinumab remains a safety and effective drug for PsO patients also in the IL-23 and JAK inhibitors era. The rescue therapy is a valid therapeutic option in case of secukinumab secondary failure.

AbstractWhile at the moment the world seems to be divided along racial lines and ‘race’ appears to be a central axe of social inclusion and exclusion, in this article we ask whether it is thinkable to go ‘beyond race’. We want to explore the idea of going ‘beyond race’ in four different ways: (1) ‘Beyond race’ as a demographic reality when people of mixed origin form the majority of population; (2) ‘Beyond race’ in regard to policies that aim at combatting inequalities also along color lines, yet are no longer dependent on a notion of race. (3) ‘Beyond race’ in terms of political mobilizations, e.g. the possibility or desirability of anti-racist movements not grounded in identity politics and (4) ‘Beyond race’ as a conceptualization of race that is decoupling biology and culture, or even to stop thinking in racial categories altogether, yet without de-politicizing any marginalised group’s, history and experience. We are aware that this questioning of race, and by implication of ethnicity, may be a typical hang-up of two authors based in Europe. We have invited authors from different parts of the world, and with different academic backgrounds to reflect in a commentary on the issues we raise and to explain their position.

AbstractThis study attempts to remedy the issue of urban voids, which are one of the possible choices for extra interactive spaces. As a city with a great civilization history, Egypt is also home to many urban voids, mainly buffer zones. This generates the research problem that urban voids result from managing isolated planning sites irrespective of the context and away from the community. Few studies tackled the impact of public spaces on city life; they were mainly theoretically oriented and focused on piazzas without highlighting other spaces or conducting empirical investigations. The study determines that voids could be a testing ground to establish a framework of how these spaces can be reused. Revitalizing urban voids goal is to reconnect these useless spaces with context, achieve users’ needs, integrate technologies with the space to revitalize the city, and increase its income through combining theoretical findings, empirical study, and questionnaires, which generate a framework that helps the planners and designers in developing urban voids and maximizing its efficiency. Currently, adaptive redesign is a hot topic to discuss, and this may be the moment to realize that following the updated design components, meeting community needs, and using technology will always reinvigorate the void.

Blockchain technology is considered one of the most revolutionary innovations that has much to offer the tourism industry, having a positive impact among consumers with the help of interactive applications but also easy to use. Tourist services must constantly evolve in a society where the consumer has everything a click away and his requirements are demanding when it comes to quality leisure. Blockchain technology has the power to change the course of the travel experience, offering the customer more autonomy, but the applications developed by the providers can offer transparency and trust to the customers from the moment T0, when the desire to go on a trip is born, until the end at which it should provide feedback. So far, digital and tourism specialists have not agreed on the development of blockchain-based applications, although the benefits are great for both consumers and tourism service providers, as in this publication we can see a series of advantages that blockchain technology can offer the tourism field. This paper also investigates the satisfaction that the Romanian consumer has after purchasing tourist services through e-commerce applications, a satisfaction that can be an additional motivation for specialists to implement blockchain technology. Following the research in this paper, it can be seen how important it is to develop a series of easy-to-use applications, because if the consumer does not manage to use the applications, this affects the degree of satisfaction and the intention to continue using the online applications for the purchase of tourism services.