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ObjectivesThis study aimed to determine the main barriers and reasons for non-adherence to preventive measures and treatment for type 2 diabetes mellitus among outpatients in Belarus.MethodsAn anonymous questionnaire survey was conducted with 814 adults aged 18 years and over who visited outpatient health care units and hospitals in Belarus. The questionnaire was developed to analyze the perceived barriers that limit adherence to preventive measures and treatment for type 2 diabetes.ResultsThe proportion of respondents who reported doing daily physical activity was 53.2%, and 46.6% consumed at least 400 grams of fruit and vegetables per day. Among the 42.8% of respondents with a prescribed treatment for type 2 diabetes mellitus, 50.1% sometimes forgot to take their medicine. The specific barriers to treatment most frequently identified by survey respondents were “Financial situation” (23.5% of respondents), and “Fear of side effects” (25.2%). Those for lifestyle instructions were “Insufficient knowledge” (29.3%), “Financial situation” (27.9%), and “Lack of motivation” (21.7%).ConclusionsThe study revealed that the main barriers to adherence were insufficient knowledge of diabetes and its treatment and an underestimation of the role of behavioral risk factors in health, combined with financial difficulties. We recommend that physicians should take a patient-centered approach to raising awareness of behavioral risk factors for type 2 diabetes mellitus, and suggest that the importance of adhering to preventative measures and treatment should be promoted in consultations in Belarus.

Ayurveda medicines uses herbs for curing many ailments without side effects. The biggest concern related to Ayurveda medicine is extinction of many important medicinal herbs, which may be due to insufficient knowledge, weather conditions, and urbanization. Another reason consists of lack of online facts on Indian herbs because it is dependent on books and experts. This concern has motivated in utilizing the machine learning techniques to identify and reveal few details of Indian medicinal herbs because, until now, it is identified manually, which is cumbersome and may lead to errors. Many researchers have shown decent results in identifying and classifying plants with good accuracy and robustness. But no complete framework and strong evidence is projected on Indian medicinal herbs. Accordingly, the chapter aims to provide an outline on how machine learning techniques can be adopted to enrich the knowledge of Indian herbs, which advantages both common man and the domain experts with wide information on traditional herbs.

Collective food toxiinfections (CFTI) are frequent accidents, formidable by their health and economic consequences. They usually result from the consumption of food contaminated with microorganisms or chemical toxins. The objective of our study is to evaluate the knowledge, attitudes and practices of food product handlers in Kloto 1 municipality in order to guarantee food safety. To do this, we carried out a survey using google form whose questions were based on knowledge of foodborne diseases, good hygiene practices, good manufacturing practices, cross-contamination, wearing jewelry during handling, waste management. As a result of the study, It shows that during the years 2018, 2019 and 2020, the frequencies of toxiinfections recorded at the PHC of Kpalimé are respectively 33.09%, 41.84%, and 25.06%. To acces risk factor about this hight case of food poissoning in this area, 197 food handlers (FH) were interviewed and of these, 54.4% were women, 51.3% are between 15 and 25 years old, 67.2% have secondary education, and 68.7% have not received training on food safety. In terms of the level of knowledge, attitudes and practices, 10.7% of FH have insufficient knowledge about food safety, 98.0% have negative attitudes and 100.0% have insufficient food safety practices. Also, it shown that there is a strong positive correlation between knowledge and attitudes (rs = 0,267; p= 0.000), between knowledge and practices (rs = 0.182; p = 0.011), between attitudes and practices (rs = 0.253; p = 0.000), and between knowledge about foodborne illness and practice (rs = 0.189; p = 0,008). In short, the majority of FH have insufficient knowledge, practice and negative attitudes to avoid cases of CFTI because of the lack of training in food safety.

The process of mobilization of Canadian volunteers, carried out by the Minister of Militia Sam Hughes during the First World War, is considered. The chronological framework is limited by the dates of Canada’s entry into the war (August 4, 1914) and the end of the active phase of the mobilization of Canadian volunteers (October 1915) in connection with the first symptoms of the army manning crisis. The relevance of the study is due to insufficient knowledge of the specifics of Canada's mobilization activity during the First World War. For the first time, ideas are formulated and the activities of the Minister of Militia S. Hughes in the process of mobilizing Canadian troops during the war years are analyzed. The sources for the study were Canadian historical and statistical collections, as well as a collection of official documents of the Canadian government and publications of the Canadian federal and provincial press for two military years (1914—1915). The article traces the views of S. Hughes on the issue of Canada's participation in the war and his activities in the field of recruiting the volunteer army (1914—1915). It is proved that the decisive character of S. Hughes and the authoritarian style of his leadership predetermined the nature of the Canadian mobilization. In fact, it got out of the control of the British authorities due to the minister's refusal from the official mobilization plan, which provided for a too slow pace of manning. Thus, the personal efforts of S. Hughes to organize the process of mobilization contributed to its complete success.

Malaysia has a nationwide COVID-19 vaccination programme to curb the COVID-19 pandemic. Medical students must help provide information about COVID-19 vaccination to the public. This study assessed the knowledge, attitude, and hesitancy towards COVID-19 vaccination among medical students. An online-based study was conducted involving 156 medical students at a private university. Sociodemographic characteristics, knowledge, attitude, and vaccination hesitancy were collected. Our research findings highlighted that insufficient knowledge and negative attitude may lead to COVID-19 vaccine hesitancy/refusal. 25% of our study population who were COVID-19 vaccine hesitant/refusal demonstrated insufficient knowledge (69.2%) and negative attitude (64.1%) towards COVID-19 vaccination. Nevertheless, 75% of the students have registered for COVID-19 vaccination, and most of them have good knowledge (59.8%) and showed positive attitude (58.1%) towards COVID-19 vaccination. Vaccination educational programmes focused on improving knowledge and cultivating positive attitude, should be conducted to maximise vaccine acceptance among medical students.

Nowadays, the part program describes only the process itself and not the obtained performance. The operator monitors just some of the variables describing the actually obtained product and appropriately adjusts the values of the programmed variables. This adjustment is realised with a considerable delay and without an adequate fundament (many times even intuitively). Moreover, process monitoring currently follows only to notice the occurrence of perturbations and, hence, of deviations from process plan. As consequence, the performance in accomplishing the manufacturing task might be diminished due to an insufficient knowledge about both the system dynamics and the conditions in which the process is performed. Starting from these premises, the challenge addressed here is to rebuild at conceptual level the monitoring system such us the monitoring becomes holistic, this meaning evaluation & reveal of machining system current state & dynamics. In other words, the holistic monitoring concerns both the values of the variables describing the system state and the relations of causality between them. In this paper, the holistic monitoring is introduced through an illustrative sample. The monitoring variables and functions are defined and sampled.

MicroRNAs (miR), as important epigenetic control factors, reportedly regulate wound repair. However, our insufficient knowledge of clinically relevant miRs hinders their potential therapeutic use. For this, we performed miR and mRNA paired expression profiling in human acute wounds and chronic non-healing venous ulcers (VU) and presented our findings on a browsable web portal (http://130.229.28.87/shiny/miRNA_Xulab/). Integrative miR and mRNA-omics analysis unraveled miR-mediated gene regulatory networks in each repair phase of the wound repair process. Importantly, we identified 17 pathologically relevant miRs exhibiting abnormal expression in VU and displaying their targetome enriched in the VU gene signature. Study of the targetome and functions of eight clinically relevant miRs in skin cells revealed that the miRs upregulated in VU (i.e., miR-34a/c-5p, miR-424-5p, miR-450-5p, miR-7704, and miR-516-5p) promoted inflammation but inhibited proliferation. In contrast, the miRs downregulated in VU (i.e., miR-218-5p and miR-96-5p) were required for cell growth and activation. Moreover, we demonstrated miR-34a, miR-424, and miR-516 cooperativity in regulating keratinocyte growth and inflammatory response. Collectively, our study suggests that VU-dysregulated miRs cooperatively contribute to stalled wound healing characterized by failed transition from inflammatory-to-proliferative phase. Targeting cooperating miRNAs provide mew opportunity for development of clinically-relevant targeted therapy to attain higher therapeutic efficacy and specificity.

Background. Diabetes mellitus is one of the most common chronic diseases, and in recent years its prevalence has been systematically increasing. Untreated or ineffectively treated diabetes leads to the development of many complications. Among these that can significantly affect the quality of life is diabetic foot syndrome (DFS). Larvotherapy is a therapeutic method of treating wounds arising during the course of DFS. Aim of the study. The main objective of this study was to assess the level of knowledge of nursing and midwifery students on the treatment of DFS using Lucilia sericata larvae. Material and Methods. This study is a cross-sectional, observational study in which 202 nursing and midwifery students of Opole University were surveyed. The study was conducted online between June and November 2020, using a questionnaire developed by the authors. Results. The analysis showed considerable variation in the level of students' knowledge of treatment techniques for DFS. Those with the highest level of knowledge represented 39.15% (n=79), the average level of knowledge was represented by 28.2% (n=57), and the lowest level of knowledge was represented by 32.7% (n=66) of students. Regarding biosurgery in general, the highest level of knowledge about biosurgery was represented by 48.0% (n=97) of students. Nursing students had a higher level of knowledge than midwifery students regarding DFS treatment methods (p=0.001). There was no difference in the level of knowledge about biosurgery between nursing and midwifery students (p=0.503). Conclusions. The research presented in this study indicates that nursing and midwifery students have insufficient knowledge of DFS treatment methods and biosurgery. Nursing students are more likely than midwifery students to derive knowledge of DFS treatment methods from their studies and the literature. Education on treatment methods and techniques for DFS should be increased among students. Students' knowledge can be increased by classes in the course of their education and meetings with professionals.

The aim of this paper is to present the results of a study on the subjective interpretation and the construction of biographies by parents of children with ADHD. The research was driven by insufficient knowledge regarding the definition of the support offered at school to a child with attention deficit hyperactivity disorder among parents and to determine what is important and unique from a parental perspective. The presented studies were constructivist, interpretative studies using the biographical method. Narrative interviews were conducted with parents of children with ADHD living in Poland. Reconstruction of their parental experiences allowed an understanding of their individual feelings and experiences, which showed “the truth” about the educational support provided to a child. The aim of the studies was a reconstruction of the narrative and an analysis of the subjective meanings which parents give to the educational support that is offered to their children at school. The central thesis took the form of a question: How did parents interpret their own experiences related to educational support given at school to a child with ADHD? The analysis of the narration shows different parental experiences regarding the educational support received. The reality reconstructed by examined parents is complex and consists of hope and expectations, but also doubts, powerlessness and helplessness. Some parts of the narration are poignant, sorrowful and rife with feelings of loneliness, which is a consequence of misunderstanding a specific child’s needs. The other parts of the narrative are dominated by happiness and joy caused by the support that a student received and its effects. By speaking about the help which was received at school, the parents expose their personal feelings towards that event, and they show their individual interpretation of the reality that they experienced. They give subjective meaning to a narrative that they feel is significant.

Vaccination of the population is the most essential and decisive measure in overcoming the COVID-19 pandemic that has involved the whole world. The vaccination of healthcare workers and medical students who can spread the infection among patients is crucial.Objective: to study the attitude towards vaccination among medical students.Patients and methods. From 18 to 22 June 2021, an anonymous Internet survey of 364 students of medical and technical universities was conducted. The sample included 135 medical students with no immunity to COVID-19 – who had not been ill or vaccinated. Three variants of behavioral strategies related to vaccination were compared: refusal to vaccinate, observation of the situation, consent to vaccination.Results and discussion. The key factors influencing the choice of a behavioral strategy for avoiding vaccination are the belief that COVID-19 infection is not dangerous for young people and that the vaccine is not studied enough. The willingness to get vaccinated is associated with denial of insufficient knowledge about the vaccine, belief in its safety and effectiveness, fear of infecting loved ones. The observer student group is characterized by an intermediate position on vaccination beliefs.Conclusion. To increase the willingness for vaccination, it is necessary, first of all, to spread the information about the vaccine, its safety (inability to cause severe complications, death) and effectiveness in preventing infection, reducing the level of anxiety concerning vaccination. It is also important to spread awareness about the danger of infecting loved ones and increase personal responsibility for the health of their loved ones.