observational research
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Background: Food security from the consumption pillar is reflected by the loyal ability of citizens to consume food that is sufficient in quantity and nutritional quality, safe, diverse and affordable. Consumption of adequate and nutritionally balanced food is a form that must be met to minimize nutritional problems including stunting.Objectives: This study aims to determine the relationship between the Expected Food Pattern (PPH) and the incidence of stunting in toddlers.Methods: The type of research used is observational research, using a cross sectional design. The research sample is 90 samples. The research location is in North Kluet District, Aceh Regency. Data analysis using SPSS Software Independent Test t-test. Research data will be presented in the form of univariate and bivariate analysis.Results: The results showed that there was no difference in the Expected Food Pattern (PPH) score between stunting toddlers and the PPH score for normal toddlers, the p value = 0.553 (p > 0.553).Conclusion: In conclusion, the PPH score in stunting toddlers with normal toddlers does not show a difference on average in North Kluet District, South Aceh.

Background. Nasopharyngeal carcinoma (NPC) is the most common malignancy in head and neck in Indonesia with 19,943 new cases in 2020 resulting 13,399 deaths. Lymphocytes are cells that play a role in the anti-cancer immune response, especially CD-8 T-cells. Neoadjuvant chemotherapy is chemotherapy given before radiotherapy that aims to kill primary tumors and micrometastasis tumors. This study aims to find out the relationship of CD-8 expression to treatment response in NPC undergoing neoadjuvant chemotherapy at Dr. Mohammad Hoesin Hospital Palembang. Methods. This study is an analytical observational research study on a retrospective cohort basis. Data collection from medical records using total sampling in 15 patients pilot study of NPC patients undergoing neoadjuvant chemotherapy and conducted CD-8 examination at ORLHNS polyclinic Dr. Mohammad Hoesin Hospital Palembang from December 2018 to December 2019 that met the criteria of inclusion and exclusion. Results. From 15 samples, the average CD-8 test result before neoadjuvant chemotherapy was 24.54 ng/μL and after neoadjuvant chemotherapy was 193.56 ng/μL. There was a tendency to increase the average CD-8 from before to after completion of neoadjuvan chemotherapy with a statistically significant difference of p =0.001. ROC analysis found CD-8 cut off points is 23.76 ng/μL with an area below the curve is 0.667. There were no significant relationships between CD-8 to performance status and treatment response with p values of 0.289 and 0.219, respectively.  Conclusions. There was a significant change between CD-8 before neoadjuvant chemotherapy and after neoadjuvant chemotherapy with increased CD-8 tendencies and trends from before to after 6 series neoadjuvant chemotherapy with CD-8 cut off points is 23.76 ng/μL. In this study there has not been a significant relationships between CD-8 to performance status and treatment response in NPC patients undergoing neoadjuvant chemotherapy.

Abstract Phenomenology has been adapted for use in qualitative health research, where it’s often used as a method for conducting interviews and analyzing interview data. But how can phenomenologists study subjects who cannot accurately reflect upon or report their own experiences, for instance, because of a psychiatric or neurological disorder? For conditions like these, qualitative researchers may gain more insight by conducting observational studies in lieu of, or in conjunction with, interviews. In this article, we introduce a phenomenological approach to conducting this kind of observational research. The approach relies on conceptual grounding to focus a study on specific aspects of the participants’ experiences. Moreover, the approach maintains the openness to novel discoveries that qualitative research requires while also providing a structured framework for data collection and analysis. To illustrate its practical application, we use examples of hemispatial neglect—a neurologic disorder in which patients characteristically lack awareness of their own illness and bodily capacities. However, the approach that we describe can be applied more broadly to the study of complex illness experiences and other experiential alterations.

  This research is a classroom action research (Classroom Action Research) which aims to improve the learning outcomes of history subjects through the jigsaw cooperative learning model in class X students of SMK Muhammadiyah Watansoppeng. The research was carried out in the odd semester of 2021/2022 with 17 students as research subjects consisting of 9 men and 8 women. The research procedure was carried out in 4 stages, namely planning, action, observing and reflecting. The number of cycles is 2 cycles, each cycle consists of 4 meetings. Data were collected through tests and non-tests (observation and recording) for the activities that occurred during the learning of history subjects. Data were analyzed using qualitative analysis techniques and quantitative analysis. While the data validation technique was done by saturation and triangulation. The results showed that the average score of student learning outcomes in the first cycle was 70.00 and in the second cycle there was an increase of 78.53.The percentage of students' completeness in the first cycle was 64.71% and the second cycle was 94,12 %. The results of observational research indicate that there is an increase in the quality of learning activities to cycle II both in terms of attendance, activeness in learning and active involvement in working individually and in groups with home groups and expert groups. The conclusion of the research results supports the research hypothesis that through the jigsaw type cooperative learning model can improve the learning outcomes of history subjects for class X students of SMK Muhammadiyah Watansoppeng, Soppeng Regency for the 2021/2022 academic year. ABSTRAKPenelitian ini adalah penelitian tindakan kelas ( Classroom Action Research) yang bertujuan untuk meningkatkan hasil belajar mata pelajaran sejarah melalui model pembelajaran kooperatif jigsaw pada siswa kelas X SMK Muhammadiyah Watansoppeng.Penelitian dilaksanakan pada semester ganjil tahun 2021/ 2022 dengan subyek penelitian 17 siswa yang terdiri dari 9 orang laki-laki dan 8 orang perempuan. Prosedur penelitian di lakukan dengan 4 tahap yaitu planning, action, observing dan reflecting. Jumlah siklus adalah 2 siklus yang tiap siklusnya terdiri atas 4 kali pertemuan. Data di kumpul melalui tes dan non tes (observasi dan perekaman) di maksud untuk aktivitas yang terjadi selama pembelajaran mata pelajaran sejarah berlangsung. Data dianalisis dengan mengunakan teknik analisis kualitatif dan analisis kuantitatif. Sedangkan teknik validasi data dilakukan saturasi dan triannggulasi.Hasil penelitian menunjukkan bahwa skor rata-rata hasil belajar siswa pada siklus I sebesar 70,00 dan pada siklus II mengalami peningkatan sebesar 78,53. Persentase ketuntasan siswa pada siklus I sebesar 64,71% dan siklus II sebesar 94,12% . Hasil penelitian observasi menunjukkan bahwa ada peningkatan kualitas aktivitas pembelajaran ke siklus II baik dari segi kehadiran,keaktifan dalam pembelajaran serta keterlibatan aktif dalam bekerja individu maupun berkelompok dengan kelompok asal maupun kelompok ahli. Kesimpulan hasil penelitian mendukung hipotesis penelitian yaitu melalui model pembelajaran kooperatif tipe jigsaw dapat meningkatkan hasil belajar mata pelajaran sejarah siswa kelas X SMK Muhammadiyah Watansoppeng Kabupaten Soppeng tahun pelajaran 2021/2022.

Abstract Background: Curiosity and need are the major forces driving invention and discoveries. The covid-19 pandemic is said to be originated from Wuhan of Hubei province in china. This statement has raised many questions and doubts about origin and spread of disease and the controversy is still going on. The geographical location of Wuhan in relation to sea is of significant value in relation to covid-19 pandemic as observed in this research. The city of Wuhan is located on both banks of the Changjiang (the Great River, a.k.a the Yangtze River) about six hundred miles upstream from Shanghai and the Pacific Ocean. It is about four hundred miles upstream from Nanjing. Its location is supremely strategic, being where the Hanshui (Han River) joins the Changjiang. The Wuhan Huanan Seafood Wholesale Market was in news and highlighted by several media and news agency as probable source of origin of covid-19. The Huanan Seafood Market located in Wuhan is a live animal and seafood market in Jianghan District, Wuhan City, and the capital of Hubei Province in Central China. Objective: This continuous observational research analysis aimed to assess the impact of geographical locations particularly coastal influence on the total/average/maximum/minimum confirmed cases and deaths from COVID-19/SARS-CoV-2 pandemic in 36 states and union territories of India, during COVID-19 pandemic from the beginning of pandemic cases in January 2020 in India with special focus on coastal states and union territories of India. The coast is also known popularly as the coastline or seashore is the area where land meets the sea or ocean, or as a line that forms the boundary between the land and the ocean. The term coastal state and union territories is used to refer to a state where interactions of sea and land of states occur. The study also aims to find safest geographical location in covid-19 pandemic.Methods: This is a novel cross-sectional mixed (quantitative and Qualitative) continuous observational research study. The information on the number of cases and deaths due to COVID-19 pandemic in 36 states and union territories of India is obtained from Health Department, Ministry of Health and Family Welfare (MoHFW), Government of India, and data were matched and analyzed from online websites as well. The impact of geographical locations on the total/average/maximum/minimum confirmed cases and deaths from COVID-19/SARS-CoV-2 pandemic in 36 states and union territories of India was analyzed with Microsoft office and with more data collection stata 15.1 for windows (64bit) will be used when required with Microsoft office in next version-3 of article (for bigger analysis) for epidemiological comparison by calculating incidence, prevalence, mortality rate and other indicators. The study for global correlation of this research is also under process by the author. For the purpose of research India is divided into four geographical areas, 1 Coastal states and union territories (total ten in numbers), 2 Island groups (three in numbers), 3 north eastern states and east area i.e. Laddakh 4 other states and union territories having plain areas (14 in numbers).Results: The findings showed that total numbers of death from covid-19 is highest in coastal states and union territories with a count of 323674 since beginning of the pandemic whereas the islands group reported the lowest total 184 numbers of deaths from covid-19 as on 05 Jan 2022, 08:00 IST (GMT+5:30) . The average death from covid-19 is highest in coastal states and union territories group with a count of 32367.4 followed by other states and union territories group with a count of 10431.21429. The islands group reported the lowest average numbers of death from covid-19 with a count of 61.33. A similar trend was found for numbers of confirmed cases with coastal states on top having largest number of covid-19 cases. In this version 2 the prevalence rates are also calculated per 100000.Conclusions: The research observation found that coastal states and union territories of India have larger number of daily cases of COVID-19 and mortality 867 per 100000 as compared to other geographical locations of the country. The observation also found that islands have least number of cases and deaths 115 per 100000 due to covid-19 pandemic. This study also gives rise to hypothesis that coastal locations are at greater risk of covid-19 infection and mortality whereas islands are safest places in covid-19 pandemics.

Background: Curiosity and need are the major forces driving invention and discoveries. The covid-19 pandemic is said to be originated from Wuhan of Hubei province in china. This statement has raised many questions and doubts about origin and spread of disease and the controversy is still going on. The geographical location of Wuhan in relation to sea is of significant value in relation to covid-19 pandemic as observed in this research. The city of Wuhan is located on both banks of the Changjiang (the Great River, a.k.a the Yangtze River) about six hundred miles upstream from Shanghai and the Pacific Ocean. It is about four hundred miles upstream from Nanjing. Its location is supremely strategic, being where the Hanshui (Han River) joins the Changjiang. The Wuhan Huanan Seafood Wholesale Market was in news and highlighted by several media and news agency as probable source of origin of covid-19. The Huanan Seafood Market located in Wuhan is a live animal and seafood market in Jianghan District, Wuhan City, and the capital of Hubei Province in Central China. Objective: This continuous observational research analysis aimed to assess the impact of geographical locations particularly coastal influence on the total/average/maximum/minimum confirmed cases and deaths from COVID-19/SARS-CoV-2 pandemic in 36 states and union territories of India, during COVID-19 pandemic from the beginning of pandemic cases in January 2020 in India with special focus on coastal states and union territories of India. The coast is also known popularly as the coastline or seashore is the area where land meets the sea or ocean, or as a line that forms the boundary between the land and the ocean. The term coastal state and union territories is used to refer to a state where interactions of sea and land of states occur. The study also aims to find safest geographical location in covid-19 pandemic.Methods: This is a novel cross-sectional mixed (quantitative and Qualitative) continuous observational research study. The information on the number of cases and deaths due to COVID-19 pandemic in 36 states and union territories of India is obtained from Health Department, Ministry of Health and Family Welfare (MoHFW), Government of India, and data were matched and analyzed from online websites as well. The impact of geographical locations on the total/average/maximum/minimum confirmed cases and deaths from COVID-19/SARS-CoV-2 pandemic in 36 states and union territories of India was analyzed with Microsoft office and with more data collection stata 15.1 for windows (64bit) will be used when required with Microsoft office in next version-3 of article (for bigger analysis) for epidemiological comparison by calculating incidence, prevalence, mortality rate and other indicators. The study for global correlation of this research is also under process by the author. For the purpose of research India is divided into four geographical areas, 1 Coastal states and union territories (total ten in numbers), 2 Island groups (three in numbers), 3 north eastern states and east area i.e. Laddakh 4 other states and union territories having plain areas (14 in numbers).Results: The findings showed that total numbers of death from covid-19 is highest in coastal states and union territories with a count of 323674 since beginning of the pandemic whereas the islands group reported the lowest total 184 numbers of deaths from covid-19 as on 05 Jan 2022, 08:00 IST (GMT+5:30) . The average death from covid-19 is highest in coastal states and union territories group with a count of 32367.4 followed by other states and union territories group with a count of 10431.21429. The islands group reported the lowest average numbers of death from covid-19 with a count of 61.33. A similar trend was found for numbers of confirmed cases with coastal states on top having largest number of covid-19 cases. In this version 2 the prevalence rates are also calculated per 100000.Conclusions: The research observation found that coastal states and union territories of India have larger number of daily cases of COVID-19 and mortality 867 per 100000 as compared to other geographical locations of the country. The observation also found that islands have least number of cases and deaths 115 per 100000 due to covid-19 pandemic. This study also gives rise to hypothesis that coastal locations are at greater risk of covid-19 infection and mortality whereas islands are safest places in covid-19 pandemics.Keywords: coastal states, COVID 19, Mortality, confirmed cases, union territories, geographical impact,

Abstract Background: In neonatal patients with necrotizing enterocolitis (NEC) and volvulus the inflammatory response is mediated by a plurality of different proteins. The proteins olfactomedin 4 (OLFM4) and lysozyme (LYZ) are part of the intestinal mucosal defense and especially OLFM4 has rarely been evaluated in neonatal gastrointestinal diseases. The aim of this study was to compare the expression levels of OLFM4 and lysozyme during NEC and volvulus in neonates. Methods: Intestinal tissues of patients with NEC and patients with volvulus were examined using immunohistochemical staining of OLFM4 and lysozyme of formalin-fixed and paraffin-embedded sections of resected tissue. Staining-positive tissues were semi-quantitatively scored from 0 (no staining), 1 (weak staining), 2 (moderate staining) to 3 (highly intense staining) by two individual investigators.Results: Both applied antibodies against OLFM4 showed different staining patterns with higher staining intensity of the antibody OLFM4 (D1E4M). OLFM4 (median score of the antibody OLFM4 (D1E4M): 3.0) and lysozyme (median score: 3.0) are highly expressed in intestinal and immune cells during NEC. The expression of OLFM4 and lysozyme in tissue with intestinal volvulus was also observable (median score of the antibody OLFM4 (D1E4M): 1.25) and median score of the antibody against LYZ: 2.0), but lower levels could be seen in comparison to tissue with NEC (p=0.033 and p=0.037, respectively).Conclusions: Both proteins, OLFM4 and lysozyme, may play a role in the pathogenesis of NEC and volvulus in neonatal patients, but the exact mechanisms of OLFM4 and lysozyme function and their role in immunological responses have not yet been resolved. These observations add new insights as basis for further large-scale population research.

Saponins are one of the secondary metabolites found in Shallot (Allium cepa L.), particularly in the roots. Microclimate differences in the cultivation area are thought to have a significant impact on the production of secondary metabolites, such as saponins. This research aimed to observe the saponins content in the root of shallot plants cultivated in marginal agricultural land and their antimicrobial activity against bacteria (Ralstonia solanacearum) and fungus (Fusarium oxysporum). This research was observational research with a random sampling method. The samples were collected from the shallot plantation with two different cultivation conditions. Two varieties of ‘Bima' and 'Tiron' cultivated by farmers in sandy coastal land Samas, Bantul were used. The plants were harvested at 1, 1.5, and 2 months after planting, respectively. The crude saponins extract was used to test antimicrobial activity. Shallot plants cultivated in marginal coastal sandy land produced higher saponins accumulated in their roots. The saponins production increased along with the maturity of shallot plants, both cultivated in marginal coastal sandy land and regular paddy field. The saponins extracted from the roots of shallots cultivated in both marginal and regular land showed higher antimicrobial activity than antifungal activity. Saponin merupakan salah satu metabolit sekunder yang terdapat pada bawang merah (Allium cepa L.), terutama pada bagian akar. Perbedaan iklim mikro pada lahan budidaya diduga akan berpengaruh terhadap produksi metabolit sekunder termasuk saponin. Tujuan penelitian ini adalah untuk mengetahui kandungan saponin pada bagian akar tanaman bawang merah yang dibudidayakan di lahan pertanian marginal serta aktivitas antimikrobanya terhadap bakteri (Ralstonia solanacearum) dan jamur (Fusarium oxysporum). Penelitian ini merupakan penelitian observasi dengan metode pengambilan sampel secara acak. Sampel berasal dari perkebunan bawang merah dengan dua lahan budidaya yang berbeda. Digunakan dua varietas yaitu 'Bima' dan 'Tiron' yang dibudidayakan oleh petani di daerah pantai Samas,kabupaten Bantul. Bahan tanaman dipanen pada tiga waktu berbeda, yaitu 1 bulan, 1,5 bulan dan 2 bulan berturut-turut setelah tanam. Ekstrak kasar saponin digunakan untuk menguji aktivitas antimikrobanya. Tanaman bawang merah yang dibudidayakan di lahan marginal pasir pantai menghasilkan saponin yang  lebih tinggi yang terakumulasi pada akarnya. Produksi saponin semakin meningkat seiring dengan umur tanaman bawang merah, baik yang dibudidayakan di lahan marginal pasir pantai maupun di lahan sawah biasa. Saponin yang diekstraksi dari akar bawang merah yang dibudidayakan di lahan marginal dan lahan biasa menunjukkan aktivitas antimikroba yang lebih tinggi daripada aktivitas antijamurnya.

Dengue Hemorrhagic Fever is still one of the public health problems in the Merek District and tends to show a fluctuating increase. It was reported that in 2017 the total number of DHF cases was 38 cases with a morbidity or Incidence Rate (IR) of 9.4 / 100,000 population, while the case fatality rate (CFR) was 5.3%. DHF is caused by an imbalance between the three interacting factors, namely host, agent, and environmental factors. The use of Geographic Information System (GIS) is carried out to obtain information about the distribution of cases in each region. The purpose of this study was to determine the distribution patterns and risks that influence the incidence of dengue hemorrhagic fever (DHF) in the Merek District of Karo District. Observational research with a case-control design. The case is DHF sufferers. Control is not a sufferer of DHF. Samples were taken by simple random sampling of 62 cases and 62 controls. Where researchers do measurements on the dependent variable beforehand the effect (DHF), while the independent variables are retrospective to determine whether there is a risk of DHF events. The statistical tests used were Chi-Square (bivariate analysis) and Logistic Regression (multivariate analysis). The results of the bivariate analysis showed risk factors for age, education, use of wire mesh and eradication of mosquito nests related to the incidence of DHF. The results of multivariate analysis showed that the risk factor that played a role in the incidence of DHF was the eradication of mosquito nets. The incidence of DHF increases in people who do not have the habit of PSN (Mosquito Nest Eradication) for that practice of cleaning and draining water reservoirs, closures, and burial of used goods.

Metabolic syndrome is a metabolic disorder caused by a complex increase in obesity. Metabolic syndrome can be controlled by adhering to medication and a healthy lifestyle. Patient's behavior towards adherence to medication is carried out in order to achieve the goal of treatment itself. The research objective was to determine the effect of medication adherence on lipid profiles and abdominal circumference in metabolic syndrome (SM) patients at Hospital in Semarang. This research is an observational research. Data were collected using a cross sectional design. Data collection in this study was conducted in August - December 2020. This study used the chi-square test, the chi-square test for abdominal circumference obtained results of 0.254 which said there was no effect of drug adherence with the abdominal circumference value and the chi-square test. for LDL, the results were 0.046 and the results were 0.001 for triglycerides, which is said to have an effect on drug adherence to LDL levels and trglyceride levels. The conclusion in this study is that there is an effect of patient drug use adherence to LDL (Low Density Lipoprotein) and triglyceride levels, while there is no effect of patient drug use adherence to abdominal circumference values.