The document provides dosages and treatment guidelines for various analgesics, anxiolytics, corticosteroids, antifungals, antivirals, and antidepressants commonly used to treat oral conditions. It notes that doses may need modification for individuals other than fit adults and cautions about potential contraindications, drug interactions, and side effects of the different medications.
The document provides dosages and treatment guidelines for various analgesics, anxiolytics, corticosteroids, antifungals, antivirals, and antidepressants commonly used to treat oral conditions. It notes that doses may need modification for individuals other than fit adults and cautions about potential contraindications, drug interactions, and side effects of the different medications.
The document provides dosages and treatment guidelines for various analgesics, anxiolytics, corticosteroids, antifungals, antivirals, and antidepressants commonly used to treat oral conditions. It notes that doses may need modification for individuals other than fit adults and cautions about potential contraindications, drug interactions, and side effects of the different medications.
The document provides dosages and treatment guidelines for various analgesics, anxiolytics, corticosteroids, antifungals, antivirals, and antidepressants commonly used to treat oral conditions. It notes that doses may need modification for individuals other than fit adults and cautions about potential contraindications, drug interactions, and side effects of the different medications.
Copyright:
Attribution Non-Commercial (BY-NC)
Available Formats
Download as PDF, TXT or read online from Scribd
Download as pdf or txt
You are on page 1/ 5
COMMON TREATMENT MEASURES Doses given are for fit adults and may need to be modified for others.
Check pharmacopoiea for other contraindications, cautions and interactions 2010 Analgesics
Analgesic
Dosage
Contra-indications
Non-steroidal anti-inflammatory drugs (NSAIDS)
Mefenamic acid
250-500mg up to 3 times a day
Asthma, gastrointestinal, renal and liver disease, pregnancy
Diflunisal
250-500mg twice a day
Pregnancy, peptic ulcer, allergies, renal and liver disease
Non-NSAIDS
Paracetamol (acetaminophen)
500-1000mg up to 6 times a day (max 4mg daily)
Liver or renal disease, alcoholism or those on zidovudine
10-60mg up to 6 times a day (or 30mg IM) 30mg up to 4 times a day (or 50mg IM)
Late pregnancy and liver disease
Dihydrocodeine
Children, hypothyroidism, asthma, renal disease
Anxiolytics
Anxiolytic
Dose
Comments Avoid in glaucoma Use with caution in the elderly Avoid in glaucoma Use with caution in the elderly
Diazepam
2-30mg daily in divided doses
Temazepam
5-10mg nocte
Corticosteroids
Corticosteroid
Topical dosage every 6 hours
Comments
Hydrocortisone hemisuccinate pellets
2.5mg dissolve in mouth close to ulcers
Use at an early stage of ulceration
Triamcinolone acetonide in carmellose gelatin paste DISCONTINUED 2009
Apply to lesions
Adheres best to dry mucosa; affords mechanical protection; of little benefit on tongue or palate
Betamethasone phosphate tablets
0.5mg ; use as mouthwash
More potent than preparations above; may produce adrenal suppression
Beclomethasone spray
1 puff 100 micrograms 1 puff 100 micrograms
May produce adrenal suppression
Budesonide spray
May produce adrenal suppression
Fluocinolone
Apply to lesion
May produce adrenal suppression
Fluocinonide cream, gel or ointment
Apply to lesion
May produce adrenal suppression
Clobetasol cream
Apply to lesion
May produce adrenal suppression
Prednisolone mouthwash
5mg
May produce adrenal suppression
Systemic immunosuppressants and immunomodulatory agents
Drug
Systemic dose
Comments
Prednisolone
Limit dosage in hypotension and Intially 40-80mg orally each day in diabetes mellitus divided doses, reducing as soon as possible to 10mg daily (give as enteric coated prednisolone with meals)
Azathioprine
2-2.5mg/kg daily
Contraindicated in pregnancy
Colchicine
500 micrograms, 3 times daily
Contraindicated in pregnancy, elderly, cardia renal or hepatic disease
Contraindicated in cerebrovascular haemorrhage, myocardial infarction
Antifungals
Antifungal
Dosage and duration (continue for at least 48 h after lesions have cleared)* 10mg lozenge 100mg/ml suspension 10-400mg 6 hourly for at least 14-21 days
Possible drug interactions and contraindications
Amphotericin (topical)
Topical use; no problems
Nystatin (topical)
500 000 unit lozenge 100 000 unit pastille 100 000 unit per ml of suspension 100,000 units 6 hourly for at least 14-21 days
Topical use; often no problems but ma unpleasant taste, nausea or gastrointes disturbance
Miconazole (topical)
250mg tablet 25mg/ml gel 250mg 6 hourly for at least 14 -21days 50mg/g denture lacquer; apply weekly for at least 2 weeks
May interact with many drugs includin antidiabetics, anticoagulants, phenytoi midazolam, ciclosporin, cisapride and Avoid in pregnancy, porphyria. Even topical agent may be absorbed systemically. May impair oral contraceptive Not absorbed in achlorhydria. May int many drugs including anticoagulants, midazolam, cyclosporin, sertindole, te cisapride and astemizole. Avoid in pre porphyria. Hepatotoxic. Expensive May impair oral contraceptive May interact with many drugs includin antidiabetics, anticoagulants, phenytoi midazolam, cyclosporin, zidovudine, terfenadine, cisapride and astemizole. pregnancy, porphyria. May sometimes hepatotoxic and myelosuppressive. Ex May impair oral contraceptive Not absorbed in achlorhydria .May int
Ketoconazole (oral)
200-400mg daily for at least 14 days
Fluconazole (oral)
50-200mg daily for at least 14 days
100 mg capsules
Itraconazole (oral)
100-200mg daily for at least 14 days 10mg/ml liquid 10ml twice daily for at least 14 days
many drugs including digoxin, sertind anticoagulants, phenytoin, midazolam simvastatin, terfenadine, cisapride and Avoid in pregnancy, porphyria. Expen May impair oral contraceptive
* the higher doses are used in HIV infection
Antivirals
Disorder
Drug/dosage
Herpes simplex stomatitis
Aciclovir 100-200mg tablets five times daily, or oral suspension (200mg/5ml) five times daily Penciclovir 1% cream every 2 hours or 5% aciclovir cream every 2 hours
Recurrent herpes
Herpes varicella-zoster
Aciclovir 800mg oral five times daily or famciclovir 250mg three times daily, or famciclovir 750mg once daily
(Aciclovir (systemic preparations) - caution in renal disease and pregnancy. Occasional increase in liver enzymes and urea, rashes, CNS effects. Famciclovir - caution in renal disease and pregnancy. Occasionally causes nausea and headache).
Some antidepressants
Antidepressant Amitriptyline
Dose 25-75mg daily divided dose
Comments Contraindicated in recent myocardial infarction, arrhythmias, liver disease Contraindicated in recent myocardial infarction, arrhythmias, liver disease Contraindicated in recent myocardial infarction, arrhythmias, liver disease Caution with epilepsy, pregnancy, cardiac, liver, kidney disease, allergy or mania Contraindicated in pregnancy. cardiac arrhythmias and uncontrolled hypertension. Caution in glaucoma, bleeding disorders, breast feeding, hepatic or renal disease, and epilepsy. Avoid abrupt withdrawal.
Dothiepin
25mg three times a day or 75mg at night 10-100mg daily in divided doses
