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Material Safety Data Sheet

Acetic anhydride MSDS
Section 1: Chemical Product and Company Identification
Product Name: Acetic anhydride Catalog Codes: SLA1693 CAS#: 108-24-7 RTECS: AK1925000 TSCA: TSCA 8(b) inventory: Acetic anhydride CI#: Not available. Synonym: Chemical Formula: (CH3CO)2) Contact Information: Sciencelab.com, Inc. 14025 Smith Rd. Houston, Texas 77396 US Sales: 1-800-901-7247 International Sales: 1-281-441-4400 Order Online: ScienceLab.com

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Fire Re a c t iv it y P e rs o n a l P ro t e c t io n

CHEMTREC (24HR Emergency Telephone), call: 1-800-424-9300 International CHEMTREC, call: 1-703-527-3887 For non-emergency assistance, call: 1-281-441-4400

Section 2: Composition and Information on Ingredients

Composition: Name Acetic anhydride CAS # 108-24-7 % by Weight 100

Toxicological Data on Ingredients: Acetic anhydride: ORAL (LD50): Acute: 1780 mg/kg [Rat]. DERMAL (LD50): Acute: 4000 mg/kg [Rabbit].

Section 3: Hazards Identification

Potential Acute Health Effects: Extremely hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Very hazardous in case of skin contact (corrosive). Hazardous in case of skin contact (permeator). Liquid or spray mist may produce tissue damage particularly on mucous membranes of eyes, mouth and respiratory tract. Skin contact may produce burns. Inhalation of the spray mist may produce severe irritation of respiratory tract, characterized by coughing, choking, or shortness of breath. Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. Potential Chronic Health Effects: CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance is toxic to lungs, mucous membranes. Repeated or prolonged exposure to the substance can produce target organs damage. Repeated or prolonged contact with spray mist may produce chronic eye irritation and severe skin irritation. Repeated or prolonged exposure to spray mist may produce respiratory tract irritation leading to frequent attacks of bronchial infection.

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Section 4: First Aid Measures

Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention immediately. Skin Contact: In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Cover the irritated skin with an emollient. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention immediately. Serious Skin Contact: Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medical attention. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention immediately. Serious Inhalation: Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. WARNING: It may be hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious or corrosive. Seek immediate medical attention. Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: Flammable. Auto-Ignition Temperature: 316C (600.8F) Flash Points: CLOSED CUP: 49C (120.2F). OPEN CUP: 51C (123.8F). Flammable Limits: LOWER: 2.7% UPPER: 10.3% Products of Combustion: These products are carbon oxides (CO, CO2). Fire Hazards in Presence of Various Substances: Flammable in presence of heat. Explosion Hazards in Presence of Various Substances: Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in presence of static discharge: Not available. Fire Fighting Media and Instructions: Flammable liquid. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use alcohol foam, water spray or fog. Cool containing vessels with water jet in order to prevent pressure build-up, autoignition or explosion. Special Remarks on Fire Hazards: Not available. Special Remarks on Explosion Hazards: Not available.

Section 6: Accidental Release Measures

Small Spill: Absorb with an inert material and put the spilled material in an appropriate waste disposal. p. 2

Large Spill: Flammable liquid. Corrosive liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth, sand or other non-combustible material. Do not get water inside container. Do not touch spilled material. Use water spray curtain to divert vapor drift. Prevent entry into sewers, basements or confined areas; dike if needed. Call for assistance on disposal. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities.

Section 7: Handling and Storage

Precautions: Keep container dry. Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do not breathe gas/fumes/ vapor/spray. Never add water to this product. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes. Storage: Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed and sealed until ready for use. Avoid all possible sources of ignition (spark or flame).

Section 8: Exposure Controls/Personal Protection

Engineering Controls: Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location. Personal Protection: Face shield. Full suit. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Boots. Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure Limits: TWA: 5 TWA: 20 Consult local authorities for acceptable exposure limits.

Section 9: Physical and Chemical Properties

Physical state and appearance: Liquid. Odor: Strong. Taste: Strong. Molecular Weight: 102.09 g/mole Color: Light. pH (1% soln/water): Not available. Boiling Point: 139.9C (283.8F) Melting Point: -73.1 (-99.6F) Critical Temperature: Not available. Specific Gravity: 1.08 (Water = 1) Vapor Pressure: 0.5 kPa (@ 20C) Vapor Density: 3.52 (Air = 1) p. 3

Volatility: Not available. Odor Threshold: 0.1 ppm Water/Oil Dist. Coeff.: Not available. Ionicity (in Water): Not available. Dispersion Properties: Not available. Solubility: Not available.

Section 10: Stability and Reactivity Data

Stability: The product is stable. Instability Temperature: Not available. Conditions of Instability: Not available. Incompatibility with various substances: Not available. Corrosivity: Not available. Special Remarks on Reactivity: Not available. Special Remarks on Corrosivity: Not available. Polymerization: Will not occur.

Section 11: Toxicological Information

Routes of Entry: Dermal contact. Eye contact. Inhalation. Ingestion. Toxicity to Animals: WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oral toxicity (LD50): 1780 mg/kg [Rat]. Acute dermal toxicity (LD50): 4000 mg/kg [Rabbit]. Acute toxicity of the vapor (LC50): 1000 4 hours [Rat]. Chronic Effects on Humans: Causes damage to the following organs: lungs, mucous membranes. Other Toxic Effects on Humans: Extremely hazardous in case of skin contact (irritant), of ingestion, . Very hazardous in case of skin contact (corrosive). Hazardous in case of skin contact (permeator), of eye contact (corrosive), of inhalation (lung corrosive). Special Remarks on Toxicity to Animals: Not available. Special Remarks on Chronic Effects on Humans: Not available. Special Remarks on other Toxic Effects on Humans: Not available.

Section 12: Ecological Information

Ecotoxicity: Not available. BOD5 and COD: Not available. Products of Biodegradation: Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself. Special Remarks on the Products of Biodegradation: Not available.

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Section 13: Disposal Considerations

Waste Disposal:

Section 14: Transport Information

DOT Classification: Class 8: Corrosive material Identification: : Acetic Anhydride UNNA: UN1715 PG: II Special Provisions for Transport: Not available.

Section 15: Other Regulatory Information

Federal and State Regulations: Pennsylvania RTK: Acetic anhydride Massachusetts RTK: Acetic anhydride TSCA 8(b) inventory: Acetic anhydride CERCLA: Hazardous substances.: Acetic anhydride Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). Other Classifications: WHMIS (Canada): CLASS B-3: Combustible liquid with a flash point between 37.8C (100F) and 93.3C (200F). CLASS E: Corrosive liquid. DSCL (EEC): R10- Flammable. R20/22- Harmful by inhalation and if swallowed. R34- Causes burns. HMIS (U.S.A.): Health Hazard: 3 Fire Hazard: 2 Reactivity: 0 Personal Protection: National Fire Protection Association (U.S.A.): Health: 3 Flammability: 2 Reactivity: 1 Specific hazard: Protective Equipment: Gloves. Full suit. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. Face shield.

Section 16: Other Information

References: Not available. Other Special Considerations: Not available. Created: 10/10/2005 08:13 PM Last Updated: 11/01/2010 12:00 PM The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume p. 5

no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.com has been advised of the possibility of such damages.

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