Infertility: They Can't Have Bab Ies
Infertility: They Can't Have Bab Ies
Infertility: They Can't Have Bab Ies
with Alice?
ha ve b a bi e s
They can’t
ertility
• the inability to achieve pregnancy after at
least 1 year of regular intercourse without
contraception
• assessment and therapy measures can be
invasive, expensive and lengthy
• understandably, infertility can constitute a
physical and an emotional crisis.
lit y
• infertility may be caused by either male,
female, or combined factors
• in up to 20% of the couples evaluated, the
cause of infertility may not be identified
Etiology &
athoph y si o l o gy
• the most frequent female causes of infertility
include:
– ovulation
– tubal obstruction or dysfunction
– uterine or cervical factors
Etiology &
athoph y si o l o gy
• risk factors:
– tobacco
– illicit drug use
– infection of the reproductive tract
– and specific occupational and environmental
exposures
Etiology &
athoph y si o l o gy
• risk of infertility increases with age
• the probability of becoming pregnant begins
decreasing at age 35 and decreases even
further after age 40
Etiology &
athoph y si o l o gy
• history and physical examination of both
partners, including psychosocial functioning
• counseling
• review of menstrual and gynecological history
• assessment of possible sexually transmitted
diseases
• basal body temperature record
• serum hormone levels
• urinary LH
c Studies
• sperm penetration assay
• Pap test
• semen analysis
• ovulatory study
• tubal patency study
• postcoital test
• endometrial biopsy
• hysterosalphingogram
• pelvic ultrasound
• genetic screening
c Studies
Drug Mechanism of action
Clomiphene Stimulate hypothalamus to increase production of
GnRH, which increase release of LH and FSH; end
result is stimulation of ovulation.
e r a p ie s
Drug Mechanism of action
Cetrorelix Prevent premature LH surges and premature
Ganirelix ovulation in women undergoing ovarian stimulation.
e r a p ie s