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Infertility: They Can't Have Bab Ies

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Doc, what’s wrong

with Alice?

ha ve b a bi e s
They can’t
ertility
• the inability to achieve pregnancy after at
least 1 year of regular intercourse without
contraception
• assessment and therapy measures can be
invasive, expensive and lengthy
• understandably, infertility can constitute a
physical and an emotional crisis.

lit y
• infertility may be caused by either male,
female, or combined factors
• in up to 20% of the couples evaluated, the
cause of infertility may not be identified

Etiology &
athoph y si o l o gy
• the most frequent female causes of infertility
include:
– ovulation
– tubal obstruction or dysfunction
– uterine or cervical factors

Etiology &
athoph y si o l o gy
• risk factors:
– tobacco
– illicit drug use
– infection of the reproductive tract
– and specific occupational and environmental
exposures

Etiology &
athoph y si o l o gy
• risk of infertility increases with age
• the probability of becoming pregnant begins
decreasing at age 35 and decreases even
further after age 40

Etiology &
athoph y si o l o gy
• history and physical examination of both
partners, including psychosocial functioning
• counseling
• review of menstrual and gynecological history
• assessment of possible sexually transmitted
diseases
• basal body temperature record
• serum hormone levels
• urinary LH

c Studies
• sperm penetration assay
• Pap test
• semen analysis
• ovulatory study
• tubal patency study
• postcoital test
• endometrial biopsy
• hysterosalphingogram
• pelvic ultrasound
• genetic screening

c Studies
Drug Mechanism of action
Clomiphene Stimulate hypothalamus to increase production of
GnRH, which increase release of LH and FSH; end
result is stimulation of ovulation.

Pergonal Product made of equal amounts of FSH and LH


Repronex that promotes the development and maturation
Humegon of follicles in the ovaries.

Urofollitropin Stimulate follicle growth and maturation by


Follitropin mimicking the actions of the body’s natural FSH

e r a p ie s
Drug Mechanism of action
Cetrorelix Prevent premature LH surges and premature
Ganirelix ovulation in women undergoing ovarian stimulation.

Leuprolide Suppress release of LH and FSH with continuous


Nafareline use. May also be used in the treatment of
endometriosis.

Pregnyl Induces ovulation by stimulating the release of eggs


Profasi from follicles.
Novarel

e r a p ie s

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