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DS Erythropoietin

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Erythropoietin, Epoetin Alfa

Generic Name

Brand Name Drug Classification Ordered Dose Indications

Epogen, procrit Recombinant human erythropoietin 400 units SQ 2x in one week Treatment of anemia related to chronic renal failure (CRF) Anemia related to zidovudine therapy in HIV-infected patients Anemia due to chemotherapy in patients with metastatic nonmyeloid malignancies

Contraindications

Contraindicated with Hypersensitivity to mammalian cellderived products or human albumin; uncontrolled hypertension. Cardiovascular: Hypertension; deep venous thrombosis CNS: Fatigue; dizziness, insomnia; headache; anxiety, paresthesia Dermatologic: Pruritus; rash

Adverse Effects

GI: Nausea; constipation; vomiting; diarrhea; dyspepsia Genitourinary: UTI Local: Skin reaction at injection site Respiratory: shortness of breath

Nursing Responsibilities

Assess clients allergy to mammalian cellderived products or human albumin; uncontrolled hypertension Determine Hgb twice a week in CRF patients and once weekly in zidovudine-treated HIV patients until Hgb has stabilized and the maintenance dose has been established. Then, determine Hgb weekly for at least 4 wk, until it has been determined that Hgb has stabilized in response to the dose change. Then, monitor at regular intervals. Closely monitor BP during therapy. Monitor iron stores, including transferrin saturation and serum ferritin, renal function, fluid and electrolyte balance, CBC with differential and platelet count, and serum chemistry regularly. In CRF patients, after any dose adjustment, determine the Hgb twice

weekly for at least 2 to 6 wk until it is determined that the Hgb has stabilized. Then monitor at regular intervals.

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