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LESSON PLAN IN ORGANIC CHEMISTRY (NS 7) (AMINES) I.

OBJECTIVES: At the end of a one hour discussion, the students will be able to: A. Identify the differences of amines to other organic compounds B. Recognize the importance of amines C. Determine the structure and classification of amines LEARNING CONTENT: A. Subject Matter Amines B. References http://www.slideshare.net (Amines Lecture Presented by: Victor R. Oribe. Manuel S. Enverga University Foundation.November 22, 2012) http://www.britannica.com/EBchecked/topic/20665/amine/277710/Us es-of-amines Freeman,W.H.et al.Principle of Organic Chemistry.1959 Prof. Dalida,Maria Conception C. Compilation of Organic Chemistry.Lyceum of the Philippines C. Materials chalk, display board, cartolina, manila paper, colored paper, and tape III. METHODOLOGY:

II.

Teachers Activities A. Routinary Activities 1. 2. 3. Prayer Greetings Checking of attendance

Students Activities

B. Motivation Today I want you to group into two. Please count then after that you may go to your respective group. I have here some questions in our past discussion and the group who have higher scores and answer it correctly will be the winner. Are you ready class? C. Presentation of the Lesson Our lesson for today is about amines. Do you have any idea about amines?

Yes mam.

Very good. Another idea? Thank you for your answer. Now, we will define what exactly what amines are. D. Lesson Proper Amines are carbon hydrogen nitrogen compounds. Amine occurs widely in living organisms. Many amines are naturally occurring compounds that are very active physiologically. Numerous drugs used for the treatment of mental illness, hay fever, heart problems, and other physical disorders are amines. Did you understand it class? We will proceed to structure and classification of amines. Amines are classified as primary (10), secondary (20), or tertiary (30) on the basis of how many hydrocarbon groups are bonded to the ammonia nitrogen atom. We will discuss first the primary amine. Who have any idea about that? You are correct. The generalized formula for a primary amine is RNH2. The functional group present in a primary amine, the NH2 group is called an Amino group. An Amino group is the - NH2 functional group. CH3 NH2. Next is secondary amine. What is the generalized formula of secondary amine? Very good. Example is it formula CH3 NH CH3. The last is tertiary amine. The generalized formula for a tertiary amine is R3N.

Yes mam, amines are carbon hydrogen nitrogen compounds.

Yes mam.

The generalized formula for a primary amine is RNH2.

The generalized formula for a secondary amine is R2NH.

Are we clear in the classification of amines? We will proceed to the properties of amines. Please read the properties of amines.

Yes mam.

1. Highly polar, primary and secondary amines can form hydrogen bonds in pure state.

2. With fewer than 5 carbon atomsgenerally water soluble. 3. Have higher boiling points than alkanes of similar molecular weights. 4. Low molecular weight amines have distinctive fishlike aroma; some have putrid odors.

Okay, thank you. The simples amines are irritating to the skin, eyes, and mucous membranes and are toxic by ingestion. Aromatic amines are generally toxic. The boiling point of amines are lower than those of corresponding alcohols, because N H bonds are weaker than O H bonds. Amines with fewer than six carbon atoms are infinitely soluble in water. In naming amines it is based in the IUPAC system. For simple amines; the suffix amines is added to the name of alkyl substituents or the suffix amine can be used in placed of the final e in the name of the parent carbon. For amines with more than one functional group; consider NH2 as an amino substituent on the parent molecule. For example; CH3 CH3-C-NH2 CH3 Tert- butylamine 1,4-butanediamine

The name of that amine is 2aminobutanoic acid. The name of that compound is methanamine.

Can you now name this amine? NH2 CH3CH2CHCOOH Very good. Try this one CH3NH2 Correct. Naming the positive ion that results from the interaction of an amine with water is based on the following two rules: Please read.. Rule 1: For alkylamine, the ending of the name of the amine is changed from amine to ammonium ion

Thank you. Rule 2: For aromatic amines, the final e of the name of the amine is replaced by ium ion.
H2 O CH3 CH2

For example:
CH3 CH2 NH2 NH3 + OH

Ethylamine Ethylammonium ion

NH3

Anilinium ion The reaction of an acid with a base (neutralization) produces a salt.
CH3 NH2 amine + H Cl acid CH3 NH2Cl Amine salt

Can you please read the following? Thank you.

An amine salt is an organic compound in which the positive ion is a mono-, di-, or trisubstituted ammonium ion (RNH3 + , R2NH2+ , or R3NH+ ) and the negative ion comes from an acid. Amine salt can be obtained in crystalline form (odorless, white crystals) by evaporating the water from the acidic solutions in which amine salt are prepared. Amine salt are named using standard nomenclature procedures for ionic compound.

Heterocyclic Amines Heterocyclic amine is an organic compound in which nitrogen atoms of amine group are part of either an aromatic or a nonaromatic

ring system. Heterocyclic amines are the most common type of heterocyclic organic compound. Heterocyclic amines are the first heterocyclic compounds we have encountered that have nitrogen heteroatoms. Examples are: Pyridine, pyrolle, quinolone, imidazole, indole and pyrimidine Lastly the uses of amines. Please read its uses. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides. Some polyfunctional amines are valuable pharmaceuticals, such as ephedrine and epinephrine (adrenaline), and anesthetics, such as novocaine.

Are we clear about amines? Any question?

No mam.

E. Enrichment For our enrichment activities I want you to name the following amines: H2N CH2 CH2 NH2 (1,2F. Ethanediamine) G. NH2 (3- Hexanamine)

H. Generalization Who can summarize our topic for today or things you learn from the discussion? I. Valuing I want you to get one half crosswise

or one fourth paper and write down your learning about amines and how can it help you as a future teacher. IV. Evaluation I want each group to ask a question to the other group about amines. I want to see if you really understand amines. It should be 2 or 3 questions. V. Assignment Study the next topic which is about carbohydrates.

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