Pyrazinamid is an antitubercular agent used to treat active tuberculosis. It is given orally at a dose of 150mg daily at 0830 on an empty stomach. Common side effects include liver toxicity, arthralgias, and nausea. It is important for patients to complete the full treatment course even if symptoms improve to ensure tuberculosis is fully treated. Special precautions are needed in patients with severe liver disease.
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Pyrazinamid is an antitubercular agent used to treat active tuberculosis. It is given orally at a dose of 150mg daily at 0830 on an empty stomach. Common side effects include liver toxicity, arthralgias, and nausea. It is important for patients to complete the full treatment course even if symptoms improve to ensure tuberculosis is fully treated. Special precautions are needed in patients with severe liver disease.
Pyrazinamid is an antitubercular agent used to treat active tuberculosis. It is given orally at a dose of 150mg daily at 0830 on an empty stomach. Common side effects include liver toxicity, arthralgias, and nausea. It is important for patients to complete the full treatment course even if symptoms improve to ensure tuberculosis is fully treated. Special precautions are needed in patients with severe liver disease.
Copyright:
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Pyrazinamid is an antitubercular agent used to treat active tuberculosis. It is given orally at a dose of 150mg daily at 0830 on an empty stomach. Common side effects include liver toxicity, arthralgias, and nausea. It is important for patients to complete the full treatment course even if symptoms improve to ensure tuberculosis is fully treated. Special precautions are needed in patients with severe liver disease.
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Clinical Medications Worksheets Generic Name
Pyrazinamid e
Trade Name Dipimide Onset
Classification antitubercular agent
Dose 150mg
Route PO
Time/frequency Daily 0830
Peak
Duration 9-10 Hr
For IV meds, compatibility with IV drips and /or solutions Nursing Implications (what to focus on) Contraindications/warnings/interactions Liver disease (severe)Patients with severe liver disease who take pyrazinamide may have an increase in side effects
Mechanism of action and indications (Why med ordered) For the initial treatment of active tuberculosis in adults and children when combined with other antituberculous agents Pyrazinamide kills or stops the growth of certain bacteria that cause tuberculosis (TB). It is used with other drugs to treat tuberculosis. It is a highly specific agent and is active only against Mycobacterium tuberculosis. In vitro and in vivo, the drug is active only at a slightly acid pH. Pyrazinamie gets activated to Pyrazinoic acid in the bacilli where it interferes with fatty acid synthase FAS I. This interferes with the bacteriums ability to synthesize new fatty acids, required for growth and replication. Pyrazinamide is an important sterilizing prodrug that shortens tuberculosis (TB) therapy. However, the mechanism of action of pyrazinamide is poorly understood because of its unusual properties. In literature it has been written that the pyrazinoic acid (POA), the active moiety of pyrazinamide, disrupted membrane energetics and inhibited membrane transport function at acid pH in Mycobacterium tuberculosis. The antimycobacterial activity appears to partly depend on conversion of the drug to POA. Susceptible strains of M. tuberculosis produce pyrazinamidase, an enzyme that deaminates pyrazinamide to POA, and the vitro susceptibility of a given strain of the organism appears to correspond to its pyrazinamidase activity. Experimental evidence suggests that pyrazinamide diffuses into M. tuberculosis in a passive manner, is converted into POA by pyrazinamidase, and because of an inefficient efflux system, accumulates in huge amounts in the bacterial cytoplasm. The accumulation of POA lowers the intracellular pH to a suboptimal level that is likely to inactivate a vital target enzyme such as fatty acid synthase
Common side effects
Toxicity: liver injury Arthralgias, anorexia, nausea and vomiting, dysuria, malaise and fever, sideroblastic anemia, adverse effects on the blood clotting mechanism or vascular integrity, and hypersensitivity reactions such as urticaria, pruritis and skin rashes
Interactions with other patient drugs, OTC or herbal medicines (ask patient specifically) Other antitubercular agents unless prescribed dosing is measured (decreased) and adequate .
Lab value alterations caused by medicine
LFTs, Renal
Be sure to teach the patient the following about this medication
should be taken on an empty stomach To help clear up your TB completely, it is important that you keep taking this medicine for the full time of treatment, even if you begin to feel better after a few weeks. It is important that you do not miss any doses
