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    Karyotyping

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    Medina Zahic
    The document provides instructions for a genetic counselor to construct and analyze two karyotypes from chromosome spread sheets. The counselor will examine the karyotypes to determine if any chromosomal abnormalities exist that could cause genetic disorders in the unborn children of two expectant mothers. The counselor will then communicate the results of the genetic tests to each couple, including details about any identified genetic disorders.

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    Download as PDF, TXT or read online from Scribd

    Karyotyping

    Uploaded by

    Medina Zahic
    411 views2 pages
    The document provides instructions for a genetic counselor to construct and analyze two karyotypes from chromosome spread sheets. The counselor will examine the karyotypes to determine if any chromosomal abnormalities exist that could cause genetic disorders in the unborn children of two expectant mothers. The counselor will then communicate the results of the genetic tests to each couple, including details about any identified genetic disorders.

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    The document provides instructions for a genetic counselor to construct and analyze two karyotypes from chromosome spread sheets. The counselor will examine the karyotypes to determine if any chromosomal abnormalities exist that could cause genetic disorders in the unborn children of two expectant mothers. The counselor will then communicate the results of the genetic tests to each couple, including details about any identified genetic disorders.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    411 views2 pages

    Karyotyping

    Uploaded by

    Medina Zahic
    The document provides instructions for a genetic counselor to construct and analyze two karyotypes from chromosome spread sheets. The counselor will examine the karyotypes to determine if any chromosomal abnormalities exist that could cause genetic disorders in the unborn children of two expectant mothers. The counselor will then communicate the results of the genetic tests to each couple, including details about any identified genetic disorders.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 2

    APPENDIX B

    Karyotyping
    Introduction

    You are a genetic counselor whose job is to discuss with expecting parents
    any genetic disorder that may affect their child. Currently, you are working
    with two couples. The two expectant mothers are over thirty-five and are
    concerned that their unborn children may have chromosomal
    abnormalities. You have been given a chromosome spread of each of the
    children. For each couple, you must construct and analyze a karyotype. In
    addition, you will be expected to give each couple a brief explanation of the
    test results, including the characteristics of any genetic disorder that may
    affect their unborn child.

    Purpose

    To connect and analyze several karyotypes.

    Materials

    Glue (1)
    Ruler (1)
    Scissors (1 pair)

    Procedure

    1.

    Obtain two different chromosome spread sheets from your teacher.

    2.

    Cut out the chromosomes of one of the chromosome spread sheets.

    3.

    Arrange the chromosomes into 22 pairs on the karyotype template.


    The chromosomes of each pair should be the same length (use a
    ruler!) and have the same centromere position. They should also
    have similar banding patterns. The two remaining chromosomes are
    the sex chromosomes. Since the X and Y chromosomes are
    nonhomologous, they will not have similar lengths, centromere
    positions or banding patterns. (Refer to the normal human
    karyotype.)

    4.

    Now, place the chromosomes in order, with the longest pair at


    position 1, the shortest at position 22, and the sex chromosomes at
    position 23.

    5.

    Finally, glue each chromosome into position. Be sure to label your


    karyotype according to the chromosome spread you were given.

    6.

    Use your constructed karyotype # 1 to answer the analysis question 1.

    7.

    Repeat steps 1 to 5 for your second chromosome spread sheet.

    8.

    Use your constructed karyotype #2 to answer the analysis question 2.

    BIOLOGY 3201 CURRICULUM GUIDE

    Chromosome Spread Sheets (2)


    Karyotype Templates #s 1 and 2

    139

    APPENDIX B

    Analysis

    1.

    Analyze karyotype #1 to determine if a chromosomal abnormality


    exists.
    a)
    b)
    c)

    2.

    Analyze karyotype #2 to determine if a chromosomal abnormality


    exists.
    a)
    b)
    c)

    Further Analysis

    140

    Will the child have a genetic disorder?


    Explain the reason for your answer.
    Using the student chart, determine which genetic complication
    will affect the child.

    Will the child have a genetic disorder?


    Explain the reason for your answer.
    Using the student chart, determine which genetic complication
    will affect the child.

    3.

    Describe two procedures used by genetic counselors to obtain a DNA


    sample used for karyotyping.

    4.

    Describe two other techniques used to examine the developing fetus


    for abnormalities.

    5.

    Write a letter to one of the expectant couples, informing them of the


    results of the genetic tests. The letter must include the name of the
    genetic disorder that affects their child and the characteristics of the
    disorder. Since you are a professional, be sure that you use clear
    language to communicate the test results.

    BIOLOGY 3201 CURRICULUM GUIDE

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