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Collaborative Ocular Melanoma Study (COMS) Findings: Small Medium Large

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Karan Kumarswamy

Diane M. Murphy, 1995-present

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Collaborative Ocular Melanoma Study (COMS) Findings: Small Medium Large

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Karan Kumarswamy
39 views3 pages
Diane M. Murphy, 1995-present

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Collaborative ocular melanoma study

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Coms

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Diane M. Murphy, 1995-present

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39 views3 pages

Collaborative Ocular Melanoma Study (COMS) Findings: Small Medium Large

Uploaded by

Karan Kumarswamy
Diane M. Murphy, 1995-present

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© All Rights Reserved
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Collaborative Ocular Melanoma Study (COMS) findings

Revised 2002

SMALL MEDIUM LARGE

Reference Arch Ophthalmol 1997 Arch Ophthalmol 2001 Jul; Am J Ophthalmol 1998
Dec; 115(12):1537-1544 119(7):969-982 Jun; 125(6): 779-796
Type of study Nonrandomized, Prospective randomized Prospective randomized
prospective follow-up clinical trial clinical trial
study
Number of 204 1317 1003
patients in
study
Size of Apical height: 1.0 to 2.5 Apical height: 2.5 to 10.0 Apical height: 10.0 mm
melanomas mm mm or larger
included in Largest basal diameter: 5 Largest basal diameter: 5 Largest basal diameter:
study mm to 16 mm 16 mm or larger
Objective of To describe time to tumor I125 Brachytherapy vs. Pre-enucleation radiation
study growth and determine enucleation for treatment vs. enucleation alone for
baseline characteristics of medium tumors treatment of large tumors
associated with growth of
small tumors

Findings of 21% grew by 2 years No clinically or No significant difference


study 31% grew by 5 years statistically significant in survival rates between
Characteristics associated difference in survival rates the 2 treatments
with growth: initial tumor between the 2 treatments Age and largest basal
thickness and diameter, for up to 12 years after diameter of the tumor are
presence of orange treatment the only factors that affect
pigment, absence of prognosis
drusen, absence of RPE
changes
Collaborative Ocular Melanoma Study
(COMS)
Cornell University: Clinic #21

Principal investigator: David H. Abramson, M.D., 1986-present

Clinic coordinators: David H. Abramson, M.D., 1986-present


Katherine Budinger, COA 1995-1997
Diane M. Murphy, 1995-present
Indira S. Rollins, CST, COA, 1999-present
Agnese Romanella-Weil, RN, BSN, CRNO, 1989-1992
Camille A. Servodidio, RN, MPH, CRNO, 1986-1997
Martin Stewart, CRA, 1993-1994

Certified ophthalmologists: David H. Abramson, M.D., 1986-present


Mary Mendelsohn, M.D., 1994-1996

Radiation oncologists: Daniel Fass, M.D., 1987-1993


Beryl McCormick, M.D., 1986-present
Karen Shupak, M.D. 1993-1997

Radiation physicists: Soutung Chiu-Tsao, Ph.D., 1987-1990


Patrick Harrington, 1990-1999

Ophthalmic photographers: Dorothy A. Fong, COT


Martin Stewart, CRA, 1993-1994
Rob Wolfson, CRA, 1986-1994

Echographers: David H. Abramson, M.D., 1986-present


Indira Rollins, CST, COA, 1999-present
Camille A. Servodidio, RN, MPH, CRNO, 1986-1997

Ophthalmic pathologists: Sarah S. Frankel, M.D., 1990-1991


Winston G. Harrison, M.D., 1987-1999

Ophthalmic surgeon: David H. Abramson, M.D., 1986-present

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