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    V43 N8 P 391 Abstract

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    MeiselAdelia
    This study reviewed 225 patients with erythroderma over a 7.5 year period. The most common causes of erythroderma were underlying dermatoses (69%), idiopathic (14.2%), drug reactions (10.7%), and malignancies (4%). When underlying dermatoses and drugs were excluded, malignancy-associated erythroderma accounted for 19.6% of cases. Endogenous eczema was the most common dermatosis, while traditional medications and anti-tuberculosis drugs were commonly implicated. Skin biopsies were suggestive or diagnostic of cutaneous T-cell lymphoma in all cases. Over half of drug-related erythroderma cases showed eosinophilia on

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    V43 N8 P 391 Abstract

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    MeiselAdelia
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    This study reviewed 225 patients with erythroderma over a 7.5 year period. The most common causes of erythroderma were underlying dermatoses (69%), idiopathic (14.2%), drug reactions (10.7%), and malignancies (4%). When underlying dermatoses and drugs were excluded, malignancy-associated erythroderma accounted for 19.6% of cases. Endogenous eczema was the most common dermatosis, while traditional medications and anti-tuberculosis drugs were commonly implicated. Skin biopsies were suggestive or diagnostic of cutaneous T-cell lymphoma in all cases. Over half of drug-related erythroderma cases showed eosinophilia on

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    V43N8p391Abstract

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    This study reviewed 225 patients with erythroderma over a 7.5 year period. The most common causes of erythroderma were underlying dermatoses (69%), idiopathic (14.2%), drug reactions (10.7%), and malignancies (4%). When underlying dermatoses and drugs were excluded, malignancy-associated erythroderma accounted for 19.6% of cases. Endogenous eczema was the most common dermatosis, while traditional medications and anti-tuberculosis drugs were commonly implicated. Skin biopsies were suggestive or diagnostic of cutaneous T-cell lymphoma in all cases. Over half of drug-related erythroderma cases showed eosinophilia on

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    13 views1 page

    V43 N8 P 391 Abstract

    Uploaded by

    MeiselAdelia
    This study reviewed 225 patients with erythroderma over a 7.5 year period. The most common causes of erythroderma were underlying dermatoses (69%), idiopathic (14.2%), drug reactions (10.7%), and malignancies (4%). When underlying dermatoses and drugs were excluded, malignancy-associated erythroderma accounted for 19.6% of cases. Endogenous eczema was the most common dermatosis, while traditional medications and anti-tuberculosis drugs were commonly implicated. Skin biopsies were suggestive or diagnostic of cutaneous T-cell lymphoma in all cases. Over half of drug-related erythroderma cases showed eosinophilia on

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    391 Erythroderma: Causes and FeaturesGrace FL Tan et al

    Original Article

    Causes and Features of Erythroderma


    Grace FL Tan, 1MBBS, Yan Ling Kong, 1MBBS, Andy SL Tan, 2MBBS, MPH, Hong Liang Tey, 1MBBS, MRCP(UK), FAMS

    Abstract
    Introduction: Erythroderma is a generalised inflammatory reaction of the skin secondary to
    a variety of causes. This retrospective study aims to characterise the features of erythroderma
    and identify the associated causes of this condition in our population. Materials and Methods:
    We reviewed the clinical, laboratory, histological and other disease-specific investigations of 225
    inpatients and outpatients with erythroderma over a 7.5-year period between January 2005 and
    June 2012. Results: The most common causative factors were underlying dermatoses (68.9%),
    idiopathic causes (14.2%), drug reactions (10.7%), and malignancies (4.0%). When drugs and
    underlying dermatoses were excluded, malignancy-associated cases constituted 19.6% of the
    cases. Fifty-five percent of malignancies were solid-organ malignancies, which is much higher than
    those previously reported (0.0% to 25%). Endogenous eczema was the most common dermatoses
    (69.0%), while traditional medications (20.8%) and anti-tuberculous medications (16.7%) were
    commonly implicated drugs. In patients with cutaneous T-cell lymphoma (CTCL), skin biopsy was
    suggestive or diagnostic in all cases. A total of 52.4% of patients with drug-related erythroderma
    had eosinophilia on skin biopsy. Electrolyte abnormalities and renal impairment were seen in 26.2%
    and 16.9% of patients respectively. Relapse rate at 1-year was 17.8%, with no associated mortality.
    Conclusion: Our study highlights the significant proportion of malignancy-related erythroderma
    in those whom common underlying causes such as dermatoses and drugs have been excluded. In
    cases of drug-related erythroderma, traditional medications and antituberculous medications are
    common causes in our population. Renal impairment and electrolyte abnormalities are commonly
    seen and should be monitored in patients with erythroderma.

    Ann Acad Med Singapore 2014;43:391-4


    Key words: Cancer, Exfoliative, Malignancy

    1
    National Skin Centre, Singapore
    2
    Annenberg School for Communication, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Address for Correspondence: Tey Hong Liang, National Skin Centre, 1 Mandalay Road, Singapore 308205.
    Email: teyhongliang111@yahoo.com

    Annals Academy of Medicine

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