Bio Molecule
Bio Molecule
Biology and its subsets of biochemistry and molecular biology study biomolecules
and their reactions. Most biomolecules are organic compounds, and just
four elementsoxygen, carbon, hydrogen, and nitrogenmake up 96% of
the human body's mass. But many other elements, such as the various biometals,
are present in small amounts.
Contents
1. Types of biomolecules
2. Nucleosides and nucleotides
2.1DNA and RNA structure
3. Saccharides
4. Lignin
5. Lipids
6. Amino acids
6.1Protein structure
6.1.1Apoenzymes
6.1.2Isoenzymes
Types of biomolecules
A diverse range of biomolecules exist, including:
Small molecules:
Vitamins
Hormones, neurotransmitters
Metabolites
Covalent
Polymerization p bond name
Biomonomers Bio-oligo ! Biopolymers
rocess between
monomers
Polypeptides, proteins
Amino acids Oligopeptides Polycondensation Peptide bond
(hemoglobin...)
Monosaccharide Polysaccharides Glycosidic
Oligosaccharides Polycondensation
s (cellulose...) bond
Polyterpenes: cis-1,4-
polyisoprene natural
Isoprene Terpenes Polyaddition
rubber and trans-1,4-
polyisoprene gutta-percha
Polynucleotides, nucleic Phosphodiester
Nucleotides Oligonucleotides
acids (DNA, RNA) bond
Nucleosides and nucleotides
Examples of these
include cytidine (C), uridine (U), adenosine (A), guanosine (G), thymidine (T)
and inosine (I).
Stereo 3D image of a group I intron ribozyme (PDB file 1Y0Q); gray lines show
base pairs; ribbon arrows show double-helix regions, blue to red from 5' to 3' end;
white ribbon is an RNA product.
Saccharides
Monosaccharides are the simplest form of carbohydrates with only one simple
sugar. They essentially contain an aldehyde or ketone group in their structure. The
presence of an aldehyde group in a monosaccharide is indicated by the
prefix aldo-. Similarly, a ketone group is denoted by the prefix keto-. Examples of
monosaccharides are the hexoses glucose, fructose, and galactose and pentoses,
ribose, and deoxyribose Consumed fructose and glucose have different rates of
gastric emptying, are differentially absorbed and have different metabolic fates,
providing multiple opportunities for 2 different saccharides to differentially affect
food intake. Most saccharides eventually provide fuel for cellular respiration.
Lignin
Lipids
Lipids (oleaginous) are chiefly fatty acid esters, and are the basic building blocks
of biological membranes. Another biological role is energy storage
(e.g., triglycerides). Most lipids consist of a polar or hydrophilic head (typically
glycerol) and one to three nonpolar or hydrophobic fatty acid tails, and therefore
they are amphiphilic. Fatty acids consist of unbranched chains of carbon atoms that
are connected by single bonds alone (saturated fatty acids) or by both single
and double bonds (unsaturated fatty acids). The chains are usually 14-24 carbon
groups long, but it is always an even number.
For lipids present in biological membranes, the hydrophilic head is from one of
three classes:
Sterols, whose heads contain a planar steroid ring, for example, cholesterol.
Other lipids include prostaglandins and leukotrienes which are both 20-carbon
fatty acyl units synthesized from arachidonic acid. They are also known as fatty
acids
Amino acids
Amino acids contain both amino and carboxylic acid functional groups.
(In biochemistry, the term amino acid is used when referring to those amino acids
in which the amino and carboxylate functionalities are attached to the same carbon,
plus proline which is not actually an amino acid).
Modified amino acids are sometimes observed in proteins; this is usually the result
of enzymatic modification after translation (protein synthesis). For example,
phosphorylation of serine by kinases and dephosphorylation by phosphatases is an
important control mechanism in the cell cycle. Only two amino acids other than the
standard twenty are known to be incorporated into proteins during translation, in
certain organisms:
Besides those used in protein synthesis, other biologically important amino acids
include carnitine (used in lipid transport within a
cell), ornithine, GABA and taurine.
Protein structure
The particular series of amino acids that form a protein is known as that
protein's primary structure. This sequence is determined by the genetic makeup of
the individual. It specifies the order of side-chain groups along the linear
polypeptide "backbone".
The overall, compact, 3D structure of a protein is termed its tertiary structure or its
"fold". It is formed as result of various attractive forces like hydrogen
bonding, disulfide bridges, hydrophobic interactions, hydrophilic interactions, van
der Waals force etc.
Apoenzymes
Isoenzymes
Project Titled
Biomolecules
ACKNOWLEDGEMENT
Gershom Lal
Class XII-A