B Pharmaceutical Chemistry
B Pharmaceutical Chemistry
B Pharmaceutical Chemistry
QUESTIONAIRE:
2. This is radioactive particle that weights almost the same as helium atom.
A. x-ray D. beta ray
B. alpha ray E. ultraviolet ray
C. gamma ray
3. This is a sulfur containing ion that does not react with sulfuric acid?
A. Sulfide D. thiosulfate
B. Sulfite E. all of the given
C. Sulphate
4. A mole of a substance:
A. Contains Avogadros number particles D. A and B
B. Weighs the same as its atomic weight or E. All of the above
molecular weight expressed in grams
C. Contains the same number of particles as 12
grams of Carbon
A. 14 D. 39
B. 15 E. 54
C. 29
11. Which of the following properties of elements decreases from left to right of the
periodic table.
A. Atomic size D. non-metallic property
B. Electron affinity E. ionization potential
C. Electronegativity
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12. Which of the following processes is a physical change?
A. Distillation of water D. fermentation of coconut water
B. Digestion of food E. combustion of methane
C. Neutralization of an acid by a base
14. This refers to the direct transition of the solid state to the vapor state.
A. Deposition D. condensation
B. sublimation E. melting
C. evaporation
16. The amount of heat requited to raise the temperature of one gram of a substance by one
degree Celsius
A. Specific heat D. heat of formation
B. Standard enthalpy E. calorie
C. Heat capacity
18. In reaction , nitrogen changes from the molecular state, N2 to NO2, what happened to
nitrogen was:
A. Oxidation D. A and C
B. Reduction E. B and C
C. Neutralization
20. What is the maximum number of electrons that can be accommodated in the p subshell?
A. 2 D. 10
B. 5 E. 14
C. 6
21. When a metal binds with a non-metal , the metal will most likely:
A. Donate electron/s D. allows its electron to move in an
B. Accept electron/s unfilled orbitals
C. Share its electrons
22. This states that orbitals of the same energy will be singly filled first with electrons
before they are paired.
A. Aufbau principle D. Heisenberg Uncertainly Principle
B. Hunds rule E. n + I rule
C. Paulis Exclusion Principle
30. The ion that gives the Prussian blue precipitate with potassium ferrocyanide.
A. Ferric D. nickel
B. Ferrous E. cobalt
C. Zinc
31. Evolves gas with fruity odow when treated with ethanol and concentrated hydrochloric
acid
A. Acetate D. silicate
B. Chlorate E. chromate
C. Sulfate
32. Rochelle salt which is used as a cathartic and also as sequestering agent is:
A. KHC4H4O6 D. Na2C4H4O6
B. KNaC4H4O6 E. K2C4H4O6
C. KSbC4H4O6
34. Which of the ff. scientists is/are the author/s of the periodic law?
A. Dalton D. De Broglie
B. Proust E. Meyer and Mendeleev
C. Charles and Boyle
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35. The state of matter which occur only at temperatures near absolute zero.
A. Plasma D. Liquid
B. Solid E. Gas
C. Bose condensaes
36. These are atoms of the same element having the same protons but of different number
of neutrons.
A. Isobars D. isotopes
B. Isotones E. none of the given
C. Isomers
37. Produced by filling an orbital by an electron which is not removed from its atom but is held
mutually or share by 2 atoms concerned.
39. Atoms that are tightly bound together and behave as a single entity
A. Molecule D. mixture
B. Ion E. none of the give
C. Element
40. This grouping of elements in the periodic table is based on the number of main energy levels
filled by the electrons.
A. Family D. A and B
B. Group E. B and C
C. Period
43. This class of matter exhibits electrical property and optical property known as Tyndall effect.
A. Solution D. colloid
B. Suspension E. compound
C. Emulsion
44. The product produced from the reaction of a non-metal oxide and water.
A. Base D. Binary acid
B. Salt E. none of the given
C. Oxy acid
47. Which of the following pairs of atoms will most likely form an ionic bond
A. C and O D. C and H
B. C and Ca E. C and S
C. C and Cl
48. The percentage of C in sugar ( C12H22O11) if the atomic weight of C=12, H=1 and O=16 is
A. 3.5% D. 57.9%
B. 8.3% E. 85%
C. 42.1%
49. This refers to ability of an atom to attract electrons of another atom to its side.
A. Ionization potential D. diamagnetism
B. Electronegativity E. paramagnetism
C. Electron affinity
52. The law stating that elements combine in a fixed ratio by mass to form compounds.
A. Law of Definite Proportion D. Boyles Law
B. Law of Multiple Proportion E. Charles Law
C. Law of Thermodynamics
53. Number of valence electrons of the element with atomic number 12.
A. 8 D. 2
B. 6 E. 1
C. 4
54. The sum of atomic masses of all the atoms in a molecule or formula unit.
A. Atomic mass D. empirical mass
B. Molar mass E. none of the given
C. Molecular mass
55. The chemical reaction between an acid and a base that produces salt and water.
A. Oxidation D. Combination
B. Reduction E. Single replacement
C. Neutralization
59. An official gas that is used in pharmaceutically to mask the disagreeable taste of certain
medicines:
60. These are substances that take/absorb sufficient water from the atmosphere forming a liquid:
A. Efflorescent C. A and B
B. Deliquescent D. None of the choices
A. Phosphate C. Sodium
B. Chloride D. Bicarbonate
A. Mercury D. Iron
B. Cadmium E. Bismuth
C. Lead
65. The following are regarded as soft acids according to HSAB concept EXCEPT
A. Ag+ C. Al+3
B. Hg+2 D. none of the above
66. Official base that is pharmaceutical necessity for preparation of Aromatic Ammonia Spirit,
NF:
A. Cr D. Al
B. Cu E. Ca
C. Fe
A. H2S D. H3PO4
B. HCI E. Thioacetamide
C. Na2CO3
A. NaO + H2 C. NaCl + O2
B. Na2O + HCl D. None
74. How many moles of aluminum reacts with sulfuric acid in this reaction
Al + H2SO4 Al2SO4 + H2
A. 2 D. 5
B. 3 E. 6
C. 4
A. Al C. Al2O3
B. Fe2O3 D. Fe
A. Molecule C. compound
B. Atom D. element
80. Hard water does not lather in with soap. This is due to:
A. K C. Mg and Ca
B. Al and O D. Zn and Pb
A. Orange-red C. blue
B. Yellow D. yellow green
A. Fe D. Ni
B. C E. Pb
C. Cr
A. Lithium C. salt
B. Carbon D. iron
87. Magnesium is detected using the dyestuff_______ in alkaline solution forming a blue lake:
A. Aluminum reagent C. p-nitrobenzene resorcinol
B. Amaranth D. oxime reagent
94. Which of the following maybe seen in patients on Bismuth containing products as antacids
and antibacterial?
A. Rebound hyperacidity D. Neurological distubances
B. Achloryhdria E. Luminous vomitus
C. Black stools
A. Rubidium C. Technutium
B. Cesium D. None of these
102. Compound responsible for the pink color of Calamine USP 24:
103. The cation/s that cause/s this group of antacid to have constipating property:
A. Al+3 C. Ca+2
+2
B. Mg D. None of the given
104. Elements that are found as diatomic molecules include all except :
A. Oxygen D. Sulfur
B. Nitrogen E. Hydrogen
C. Flourine
A. Copperas C. Hausemonite
B. Lithopone D. Braunite
A. Arrhenius C. Lewis
B. Bronsted-Lowry D. none of the given
110. The oxidation state of a carbon atom is equal to the number of:
A. Oil D. A and B
B. Water E. A, B and C
C. Aqueous acids
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112. The property of a chemical agent to destroy one form of life without harming another.
A. Chemotherapy D. sterilization
B. Selective toxicity E. pasteurization
C. Antimicrobial activity
113. Anti-bacterial potencies of primary alcohols increase with molecular weight up to____ only.
A. C3 D.C6
B. C4 E. C8
C. C5
A. Primary C. tertiary
B. Secondary D. neo
119. Derivative of carboxylic acid which is formed from the removal of one molecule of water in
two RCOOH.
A. ester C. acid amide
B. acid halide D. acid anhydride
120. Carbinol is used as ending name of _____in the derived system of naming.
A. alcohols C. ethers
B. phenol D. esters
121. The suffix used in IUPAC system naming of acid halide is:
A. yl C. oate
B. oyl D. oxy
129. Which of the following benzene ring substituents can act as meta directors?
A.-Cl C. CH3
B. OH D. COOH
132. Which of the following can be prepared from the dehydration of ethanol?
A. ethylene C. ethanol
B. ether D. A & B
A. OH C. =C=
B. O- D. CH2-CH=CH2
136. Metabolism of the following drugs result in more toxic product, EXCEPT:
A. acetaminophen C. sulfatation
B. phenacetin D. glycine conjugation
139. The following are drugs that can induce auto-induction, EXCEPT
A. phenobarbital C. probenecid
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B. phenylbutazone D. alcohol
143. As of the present, it is the most used and productive method of obtaining new drugs.
A. random screening C. serendipity
B. extraction from natural sources D. molecular manipulation
148. Physicochemical property that have been studied by the QSAR approach which can be
easily quantified for complete molecules?
A. hydrophobic C. steric
B. electronic D. AOTA
149. Which of the following hormones will not undergo hydrolytic reaction?
A. human insulin C. sex hormones
B. growth hormone D. parathyroid hormone
150. Which of the following phase I metabolic reactions is involved in the conversion of
Disulfiram to N, N Diethylthiocarbamic acid?
A. oxidation C. hydrolysis
B. reduction D. dimethylation
154. A solution of antibodies derived from the serum of animals immunized with specific
antigens.
A. vaccine C. immune globulin
B. toxoid D. antotoxin
A. Interferons C. cerezyme
B. Interleukin D. monoclonal antibody
157. B-blocker that is metabolized to napthoxylactic acid after oral dose is:
A. Propanolol C. TImolol
B. Pindolol D. Atenolol
159. What is the general term that is used to refer to compounds having two hydroxyl groups
attached to two adjacent carbons?
A. Carbinol C. glycol
B. catechol D. glycerol
160. Which of the following substrates can be used to synthesize tertiary alcohols?
A. formaldehyde D. ethane
B. ethanol E. none of these
C. propanone
172. Markonikov addition of water to a double bond in a primary carbon results to the
formation of:
A. Primary alcohols C. alkanes
B. Secondary alcohol D. tertiary alcohols
H3C O- K+
H3C-----C C---CH3
CH3 CH3
CH3
A. Neobutyl- C. tert-butyl
B. Isobutyl- D. n-butyl
Br2 light ?
Br
Br
A. C.
B. Br D. Br
Br
178. The ring in an aromatic compound typically undergoes what type of reaction
A. addition C. elimination
B. substitution D. Oxidation-reduction
+ H3C AlCl3 ?
Cl
A C.
CH3
B. D.
CH3 Cl
180. Which of the following combinations of reagents is appropriate to brominates the ring
of benzene as shown below?.
Br
H NH2
CH3
B.
B. D. CH3 CH3
OH OH
H Br HO H
H3C CH3 H3C CH3
OH Br
OCH3 OCH3
H
N
?
A. C.
N N
B. D.
N HO N
Pharmaceutical Chemistry
For numbers 184-188 refer to the structure:
` H
NH H
S CH3
N CH3
CL N CH3
HO
184. Which part of the molecule is responsible for poor oral absorption?
185. Part of the molecule that renders it inactive agaist Gram negative bacteria.
186. This part of the molecule confers further strain to the beta-lactam ring.
A. Acylamino side chain C. Chlorophenyl methyl
Isoxazalidine
B. Bicylic ring system D. Carboxylic acid
187. Part of the molecule that is always present but not essential for activity
A. Acylamino side chain C. Sulphur atom
B. Bicyclic ring system D. Primary amino group
H2N S NH
O S
N
189. This part of the molecule that should not be substituted unless the compound is intended
as a prodrug
191. Which of the following functional group-intermolecular bonding pairs is applicable to the
drug-target interaction of the compound?
A. Sulphonamide Hydrogen bonding C. Amino-covalent bonding
B. Amino-ionic bonding D. Benzene ring van der Waals
Bonding
192. Which part of molecule can be replaced with a more electron-withdrawing functional group
to stabilize the ionic form of the drug?
Pharmaceutical Chemistry
A. Sulphonamide moelty C. Para-amino group
B. Thiazole moiety D. Isoxazole moiety
193. What is the major biotransformation reaction that this drug undergoes?
A. Hydrazine formation C. Hydrolysis
B. N-acetylation D. hydrolysis
O
N
NH2 NH
N
H3C O N NH2
CH3 O
O
194. What functional group does this compound lack that causes the termination of
growing DNA chain?
196. What the part renders this drug recognizable by the viral thymidylate kinase?
A. Valine residue C. 3 hydroxyl group
B. Adenine residue D. Guanosine residue
197. What functional groups are responsible for good oral absorption of this drug?
A. Adenine residue C. 3 hydroxyl group
B. Valine ester D. 5 hydroxyl group
N+
H2N O CH3
H3C
200. What part of the molecule gives the electronic stability against cholisnesterases?
A. The methylene bridge C. The quaternary nitrogen
B. The ester bond D. the primary amino group of
Urethane
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201. What is the expected of the pharmacokinetic property of this drug?
A. It is hydrolyzed before it can reach the target C. The quaternary nitrogen is
receptor responsible for its ease of excretion
B. It enters the target cell through passive D. The amino group renders the drug
diffusion pone to aromatic hydroxylation by the
cytochrome oxidases
202. What part of the molecule serves as bioisostere of the acetyl group of the
acetylcholine in terms of binding to the receptor?
A. The metylene bridge C. The N-methyl groups
B. The quaternary nitrogen D. The primary amino group of
urethane
203. Which is tru regarding the methyl group attached to the carbon beta to the
quaternary nitrogen
A. Confers selectivity of the drug to the C. its removal would increase the
muscarinic receptor stability of the drug against
cholinesterases
B. It confers selectivity of the drug to the D. Replacement with a larger alkyl
nicotinic receptor group would increase its activity
HO 2
3 1
A
4 11
12 B 10
O D 15 16
13 9 E
5 14 N CH3
17
C H
6 8
7
HO
204. Name this natural alkaloid
A. Atropine C. Phenylpropanolamine
B. Morphine D. Sphingosine
209. The following organic compounds give positive result to Lassaignes test EXCEPT:
A. Nitriles C. Thiols
B. Amides D. Amines
211. What is the color of the flame produced by halogen containing compounds in the
flame test?
A. Blue C. Green
B. Yellow D. Orange
214. The following compounds yield a violet color to FeCl3 test except:
A. Benzoic acid C. Methyl salicylate
B. Salicylic acid D. ASA
216. Methyl salicylate is prepared from the reaction of salicylic acid and:
A. NAOH C. CH3OCCOOH
B. CH3OH D. CH3OCH3
218. This is employed for the purification of organic compounds which partially or
completely decompose before their normal boiling points are reached.
A. Steam distillation C. Fractional distillation
B. Simple distillation D. Vacuum distillation
220. Hat gas can be prepared from the acid catalyzed dehydration of athanol?
A. Methane C. Ethyne
B. Ethene D. None of the given
221. The oxidation of alkene with dilute KMno4 in cold base produce:
A. Alcohol C. Carboxylic acid
B. Ether D. ketone
222. This undergoes hydrolysis in the presence of heat producing phosgene.
A. CH3Cl C. CH4
B. CH2Cl2 D. CCl4
224. A naturally occurring chelate essential in red blood cell-oxygen transport is:
A. Insulin C. Vitamin B12
B. Hemoglobin D. Ascorbic acid oxidase
225. Which of the following statement/s is/are true regarding bioprecursor drugs?
I. Antivirals are nucleoside analogs that undergo phosphorylation as a mechanism
of activation
III. Proton pump inhibitors undergo chemical activation to bind H+/K+ ATPase in
parietal cells
Pharmaceutical Chemistry
A. I, II & IV D. II & IV
B. I. III & IV E. II, III & IV
C.I & III
226. A relatively new field that helps predicts patient response to a particular drug, whether
a positive response, negative response or no response at all, on the basis of genetic
variations amongst patients.
A. Proteomics D. Pharmacogenomics
B. Anti-sense Technology E. Gene Therapy
C.Genomics
II. When blunt ends are formed after a cut an endonuclease, these two strands are difficult to
anneal or to revert back to the parent double stranded DNA molecule
III. The gene to be inserted into a cloning vector is attached with a gene enconding for
antibiotic resitance for ease of isolation & selection of cells that have acquired the rDNA
molecule
A. I & II D. I only
B. II & III E. II only
C. I, II & III
230. When are mammalian cells chose as host cells for expression of the rDNA
molecule?
A. When the protein product requires a post D. when the cloning vector is plasmid
translational modification that other host cells
are in capable of doing so
231. Given the structure below, which of the following statement/s is/are true?
I. Maximal Activity o fthis drug molecule is seen when the meta &
para positions of the ring have hydroxyl groups
II. Substitutions of the catechol ring with a resorcinol ring offers beta-1
selective agonist activity
II. Bulky substituents on the amino group confers beta-2 selectivity
233. Which of the following antihistamines is now commonly used as an appetite stimulant
due to its CNS depressant properties?
A. Meclizine D. Chlrocyclizine
B. Cylcizine E. Hydrozyzine
C.Buclizine
234. The use of this anti-ulcer agent has been limited due to its drug interactions &
potential to cause problems in male patients taking them due to incidence of gynecomastia
& impotence
A. Pantoprazole D. Pirenzepine
B. Cimetidine E. Misoprostol
C.Sucralfate
235. Primary alcohols, on oxidation, gives carboxylic acids but the oxidative reaction can be
stopped after producing the aldehyde from the primary alcohol by using what oxidizing agent?
A. KMnO4 D. THF
B. H2CrO4 E. DIBAH
C. PCC
I. Ketones
II. Esters
III. Aldehydes
A. I only D. I and III
B. II only E. I and II
C.III only
H3C N
N
N
N
CH3
A. Nicotine D. Purine
B. Caffeine E. Quinoline
C.Diazepam
N
H
A. Pyridine D. Pyrrolidine
B.Piperidine E. Cyclohexane
C. Pyrrole
240. What is the reaction depicted below and what is its significance?
O CH2
P CH2 + H3C CH2-C-CH2CH3 H3C CH2-C-CH2CH3
A. Michael Addition; best way to produce tertiary D. Reduction of Ketones; good for
carbonyl group synthesizing hydrocarbons from the
carbonyl group
B. Wittig Reaction; best way to produce tertiary E. Aldol Reaction; a good means of
Alkenes since it is very redioselective deoxygenation
C. Phosphorylation; many biomolecules are
activated by phosphorylation
H3C C C
CH2 O
A. Acetic benzoic anhydride D. Propyl benzoate
B. Benzoic propanoic anhydride E. 1-phenyl-1,2 -dioxobutane
C. 1-phenyl-1,2-butan-dione
NH
A. Lactones D. Carboxamides
B. Amides E. Lactams
C.Cyclic Carbonyl Compounds
243. For a week acid, when the pH of the solution is the same as that of the pKa of the acid,
the percentage of ionization of the acid will be:
A. 25% C. 75%
B. 50% D. 100%
B. pKa is the negative log of the ionization E. In solvents having a low dielectric
Constatant constant, dissociation may be slight
246. The water ion theory of acids and bases is attributed to:
A. Lewis D. Pearson
B. Bronsted E. Pauling
C. Arrhenius
247. An aqueous solution of the following acids is prepared. Which will be the strongest acid?
A. HCl D. Sulfuric Acid
B. HNO3 E. none, all are the same strength
C.HClO4
248. In which of the following concepts is the formation of a coordinate covalent bond a
consequence?
I. Water-Proton Theory
II. Theory of Solvent Systems
III. Bronsted Lowry Theory
IV. Lewis Theory
249. According to the Bronsted Lowry theory, which of the following is untrue?
A. strong acid give rise to a weak D. water can act either as an acid
conjugate base or a base
250. Aluminum oxide, Al203 has a molecular weight of 102. What is its equivalent weight?
A. 17 C. 51
B.34 D. 102
252. Type of radiation which consists of streams of electrons that travel 0.4 times
the speed of light
A. Alpha C. Gamma
B. Beta D. None of the given
253. The law that states that when two elements A and B form more than one compound,
the amounts of A that are combined in these compounds with a fixed amount of B are in small
whole number ratio.
A. Law of Conservation of Mass C. Law of Multiple Proportion
B. Law of definite Proportion D. None of the given
254. Elements that have atomic numbers from 58 t0 71 and appears at the bottom of the chart
are called:
A. metals C. actinides
B. non-metals D. lanthanides
Pharmaceutical Chemistry
255. The principle that states that no two electrons in the same atom may have identical sets of
all four quantum numbers
256. The quantum number that identifies the orientation of the orbital within the subshell.
A. Principal C. Azimuthal
B. Magnetic D. Spin
257. A molecular orbital in which electron density is low in the internuclear region.
A. Antibonding molecular orbital C. Hybrid orbital
B. Bonding molecular orbital D. None of the given
258. It states that when conditions are changed, a system in equilibrium reacts in a way that
tends to counteract the change.
A. Henrys law C. Raoults law
B. Le Chatelies Principle D. None of the given
259. What is the oxidation number of Cr in the dichromate ion Cr2O7 -2?
A. +5 C. +6
B. -5 D. -6
A.Zero C. Second
B.First D. Third
265. Law of thermodynamics that states that energy can be converted from one for into another
but it cannot be created or destroyed
A. First Law C. Third Law
B. Second Law D. none
266. A process, run at high pressures, at high temperatures and in the presence of a catalyst in
which hydrogen and nitrogen react to produce ammnonia
A. Bergius process C. Steam reformer process
B. Haber process D. All of the given
267. A process in which high molecular weight hydrocarbons are broken down into lower
molecular weight compounds. This process is used in petroleum refining.
272. The distance between the nuclei of two covalently bonded atoms in a molecule
A. Atomic radius D. Bond distance
B. Atomic diameter E. None of the given
C. Bond length
274. The law that states that at constant pressure and temperature, the volume of a gas is
directly proportional to the number of moles of the gas present.
276. The equation that tells the possible energy states of an electron in hydrogen atom and the
probability of its location in a particular region
A. Planks equation C. de Broglie equation
B. Schrodinger equation D. Bohr equation
287. This structure is essential for the antibacterial property of penicillins and cephalosporins:
A. 6-aminopenicillanic acid C. beta-lactam ring
B. dihydrothiazine D. sulfamoyl group
288. The first compound in the development of a drug that has the desired biological and
physiological properties.
A. prodrug C. latent drug
B. lead drug D. linker
290. These are composed of two amino sugars linked together in glycosidic linkage to a central
hexose
A. penicilins C. macrolides
B. aminoglycoside D. tetracyclines
For each of the following structures, choose the most appropriate pharmacological category:
A. Local anesthetic
B. Barbiturate
C. Analgesic
D. Adrenergic agonist
E. Anti-bacteria agent
293.
OH
N CH3
H C
294.
HO
HO CHOHCH2NH2
Pharmaceutical Chemistry
295.
H O R1
N S N
R4 O H
H3C C O
C
OH
A. Analgesic C. anti-bacterial
B. Sedative D. hypnotic
CH3
OH N(CH3)2
H H
OH
CONH2
OH
OH O OH O
A. Tetracycline C. penicilin
B. Macrolide D. aminogycoside
A. Cresol C. chlorhexidene
B. Eugenol D. thymol
A. Toxoid C. immunoglobulin
B. Vaccine D. antitoxin