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    Liver-Bile Duct Hyperplasia 508

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    Abhijith S. P
    This document discusses bile duct hyperplasia in the liver of rats. It provides figures showing examples of bile duct hyperplasia and notes that it is commonly seen in aging rats but can also be associated with toxic insults. The recommendation is to diagnose and grade bile duct hyperplasia when present as a treatment effect or when excessive, and to note any associated lesions separately.

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    Liver-Bile Duct Hyperplasia 508

    Uploaded by

    Abhijith S. P
    60 views2 pages
    This document discusses bile duct hyperplasia in the liver of rats. It provides figures showing examples of bile duct hyperplasia and notes that it is commonly seen in aging rats but can also be associated with toxic insults. The recommendation is to diagnose and grade bile duct hyperplasia when present as a treatment effect or when excessive, and to note any associated lesions separately.

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    Liver-bile Duct Hyperplasia 508

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    This document discusses bile duct hyperplasia in the liver of rats. It provides figures showing examples of bile duct hyperplasia and notes that it is commonly seen in aging rats but can also be associated with toxic insults. The recommendation is to diagnose and grade bile duct hyperplasia when present as a treatment effect or when excessive, and to note any associated lesions separately.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    60 views2 pages

    Liver-Bile Duct Hyperplasia 508

    Uploaded by

    Abhijith S. P
    This document discusses bile duct hyperplasia in the liver of rats. It provides figures showing examples of bile duct hyperplasia and notes that it is commonly seen in aging rats but can also be associated with toxic insults. The recommendation is to diagnose and grade bile duct hyperplasia when present as a treatment effect or when excessive, and to note any associated lesions separately.

    Copyright:

    © All Rights Reserved
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    of 2

    Liver, Bile duct – Hyperplasia

    Figure Legend: Figure 1 Bile duct hyperplasia in a female F344/N rat from a subchronic study.
    Figure 2 Bile duct hyperplasia in a female F344/N rat from a subchronic study (higher
    magnification of Figure 1).

    Comment: Bile duct hyperplasia is not commonly seen in prechronic studies but is a common
    aging lesion. In chronic studies, the occasional occurrence of bile duct hyperplasia in the
    absence of any differences in incidence or severity among study groups likely represents a
    background lesion. It is more commonly seen in rats than in mice. Only some portal areas may
    be affected. Biliary hyperplasia may be associated with peribiliary fibrosis. When accompanied
    by inflammatory cells and/or oval cell proliferation, bile duct hyperplasia may be the
    consequence of a toxic insult. Figure 1 and Figure 2 show a single focal area of hyperplasia;
    similar lesions were not present in the other liver sections examined from this rat. This degree of
    bile duct hyperplasia is not commonly present in control rats in subchronic studies.

    Recommendation: Bile duct hyperplasia should be diagnosed and assigned a severity grade
    whenever present as a treatment-associated change or when excessive, as in this example.
    Since bile duct hyperplasia is a common age-related change, the decision to diagnose it will
    depend upon the age of the animal. Associated lesions, such as inflammation, fibrosis, or bile
    duct dilation, should be diagnosed separately if warranted by the severity of these lesions.

    1
    Liver, Bile duct – Hyperplasia

    References:

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    (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press,
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    Greaves P. 2007. Histopathology of Preclinical Toxicity Studies: Interpretation and Relevance in


    Drug Safety Evaluation, 3rd ed. Elsevier, Amsterdam.
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    Harada T, Enomoto A, Boorman GA, Maronpot RR. 1999. Liver and gallbladder. In: Pathology
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    Hardisty JF, Brix AE. 2005. Comparative hepatic toxicity: prechronic/chronic liver toxicity in
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    Full-Text: http://tpx.sagepub.com/content/33/1/35.full.pdf

    Haschek WM, Rousseaux CG, Wallig MA. 2010. Fundamentals of Toxicologic Pathology, 2nd
    ed. Academic Press, San Diego, 197–235.
    Abstract: http://www.sciencedirect.com/science/book/9780123704696

    Thoolen B, Maronpot RR, Harada T, Nyska A, Rousseaux C, Nolte T, Malarkey D, Kaufmann


    W, Kutter K, Deschl U, Nakae D, Gregson R, Winlove M, Brix A, Singl B, Belpoggi F, Ward JM.
    2010. Hepatobiliary lesion nomenclature and diagnostic criteria for lesions in rats and mice
    (INHAND). Toxicol Pathol 38:5S–81S.
    Full-Text: http://tpx.sagepub.com/content/38/7_suppl/5S.full

    Author:

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP


    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

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