Identifying Healthcare-Associated Infections (HAI) For NHSN Surveillance
Identifying Healthcare-Associated Infections (HAI) For NHSN Surveillance
Identifying Healthcare-Associated Infections (HAI) For NHSN Surveillance
The intention of this approach is to align criteria and definitions and decrease subjectivity
while maintaining epidemiologic standardization and clinical relevance. A variety of
scenarios to include repeat infections of the same type, concurrent infections of differing
types, and pathogen assignment in multi-pathogen infections are addressed. See Appendix
Flow Diagram for NHSN Event Determination.
General Instructions
1. The guidance found in this Chapter is not applicable when performing SSI, VAE,
PedVAE or LabID surveillance. Infection window period, Date of Event, POA, HAI,
and RIT, SBAP definitions as defined in this chapter do not apply to SSI, VAE,
PedVAE, or LabID Events (Table 1).
Please refer to Chapters 9, 10, 11 and 12 respectively for guidance specific to these
event determinations
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4. Hospice, palliative or comfort care patients are not excluded from NHSN
surveillance.
6. Infections occurring in newborns with date of event on hospital day 1 or day 2 are
considered POA. Those with date of event on day 3 or later are HAI. This includes
infections acquired transplacentally (for example but not limited to herpes simplex,
toxoplasmosis, rubella, cytomegalovirus, or syphilis) or as a result from passage
through the birth canal. Exception: See guidance about non-reporting of CLABSIs
with Group B Streptococcus during a neonate’s first 6 days of life found in the
Comments and Reporting Instructions section of the Bloodstream Infection Event
(Central Line-Associated Bloodstream Infection and Non-central line-associated
Bloodstream Infection) protocol.
7. Reactivation of a latent infection (for example but not limited to herpes, shingles,
syphilis, or tuberculosis) is not considered to be an HAI.
Date of Event
Applicable
Applicable
Applicable
Applicable
POA
Not
Not
Not
Not
HAI
Repeat Infection Timeframe (RIT)†
Secondary BSI Attribution Period†
,†
See ENDO criteria in Chapter 17: CDC/NHSN Surveillance Definitions for Specific Types of
Infections for endocarditis
*See SSI, LabID,VAE, and PedVAE surveillance protocols
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The Infection Window Period (IWP) is defined as the 7-days during which all site-specific
infection criteria must be met. It includes the collection date of the first positive diagnostic
test that is used as an element to meet the site-specific infection criterion, the 3 calendar
days before and the 3 calendar days after (Table 2). For purposes of defining the Infection
Window Period the following examples are considered diagnostic tests:
3 days
Infection Window Period
before
Date of first positive diagnostic test that is used as an
element of the site-specific criterion
OR
In the absence of a diagnostic test, use the date of the
first documented localized sign or symptom that is used
as an element of the site-specific criterion
3 days
after
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It is important to use the first diagnostic test that creates an infection window period
during which all elements of the criterion can be found. See example below.
Example
When meeting PNEU definition using the PNU2 criterion, identification of an eligible
organism from blood or from a site-specific specimen, and an imaging test may be available.
Both the organism identification and the imaging test are diagnostic tests. Use the first
diagnostic test for which all elements of the PNU2 criterion occur within the infection
window period.
In this example below, Option 1 uses the imaging test (not the blood culture) to set the
infection window period. This is the first diagnostic test that creates an infection window
period in which all elements of PNU2 criterion occur.
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For site-specific infection criteria that do not include a diagnostic test, the date of
the first documented localized sign or symptom that is used as an element of the site-
specific infection criterion is used to define the infection window period for example,
diarrhea, site-specific pain, purulent drainage. Note that a non-specific sign or
symptom for example, fever is not considered to be localized and therefore is not to
be used to define the infection window period.
For example, when meeting EMET using criterion 2, there is no diagnostic test as a
part of this criterion. The date of the first documented localized sign or symptom,
purulent drainage or pain or tenderness that is used as an element to meet EMET
criterion 2 is to be used to set the infection window period. Fever is not a localized
sign.
Example
A patient has purulent drainage noted at a superficial wound site on hospital day 2. It
is documented on day 3 that the wound site is painful and swelling is present. S.
aureus is identified from a wound specimen with collection date on day 4. SKIN
definition can be met using criterion 2a with pain, swelling and positive culture from
the site-specific specimen (diagnostic test) and also met using criterion 1 with
purulent drainage (sign). Using the sign of infection, purulent drainage, to set the
infection window period results in Criterion 1 being met and provides the earliest date
of event.
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3. Endocarditis:
When meeting the Endocarditis (ENDO) definition, the Infection Window Period
(IWP) is defined as the 21 days during which all site-specific infection criteria
must be met. It includes the date the first positive diagnostic test that is used as an
element of the ENDO infection criterion was obtained, the 10 calendars days
before and the 10 calendar days after. The IWP is lengthened for ENDO to
accommodate the extended diagnostic timeframe that is frequently required to
reach a clinical determination of endocarditis.
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The Date of Event (DOE) is the date the first element used to meet an NHSN site-specific
infection criterion occurs for the first time within the seven-day infection window period
(Table 3 and Table 4).
Note:
Accurate determination of DOE is critical because DOE is used to determine:
• if an event is HAI or POA
• location of attribution
• device association
• day 1 of the Repeat Infection Timeframe
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Example 1 Example 2
HOSPITAL INFECTION HOSPITAL INFECTION
DAY WINDOW PERIOD DAY WINDOW PERIOD
1 1
2 Date of Event Fever > 38.0 C 2
3 3
4 Urine culture: 4 Date of Event Urine culture:
>100,000 CFU/ ml >100,000 CFU/ml
E. coli E. coli
5 5 Fever > 38.0 C
6 6 Fever > 38.0 C
7 7
8 8
9 9
10 10
11 11
12 12
13 13
14 14
15 15
16 16
17 17
18 18
SUTI-POA SUTI-HAI
Date of Event = 2 Date of Event = 4
Pathogen = E. coli Pathogen = E. coli
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Notes:
• Acceptable documentation includes patient-reported signs or symptoms within the POA
timeframe, documented in the medical record by a healthcare professional. Information
communicated verbally from facility to facility, or information found in another facility’s
medical record cannot be used unless also documented in the current facility’s medical
record (with the exception of post –discharge SSI surveillance.) For example, the
following would be eligible for use if documented in the current facility’s medical record:
o patients states measured fever > 38.0° C or >100.4° F occurring in the POA
timeframe
o nursing home reports fever prior to arrival to the hospital and occurring in the
POA timeframe
o patient complains of dysuria
o copy of laboratory test result from another facility
The Repeat Infection Timeframe (RIT) is a 14-day timeframe during which no new
infections of the same type are reported.
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• The RIT will apply at the level of specific type of infection with the exception of BSI,
UTI, and PNEU where the RIT will apply at the major type of infection.
Patients will have no more than one SKIN infection reported in a SKIN RIT,
but may have overlapping or simultaneous SKIN RIT and DECU RIT
• The RIT applies during a patient’s single admission, including the day of discharge
and the day after, in keeping with the Transfer Rule. An RIT does not carry over
from one admission to another even if readmission is to the same facility.
• The RIT for Endocarditis (ENDO) is extended to include the remainder of the
patient’s current admission.
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In the example below (Table 5), the Date of Event is hospital day 4. The 14-day RIT is
hospital day 4 through day 17. On hospital day 12, within the RIT, a urine culture with >
100,000 CFU/ml S. aureus is identified. The urine pathogen identified from the hospital day
12 culture is added to the originally identified infection on hospital day 4. Determination of
a new infection or continuation of ongoing infection is not required. The original date of
event and the RIT are maintained.
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In the example below (Table 6) a non-catheter associated UTI is identified with date of event
on day 4. This sets an RIT day 4 -17. On day 5 a Foley catheter is inserted. On day 8, within
the RIT, a urine culture with > 100,000 CFU/ml E.coli is identified. The E.coli is added to
the originally identified day 4 event. The device association does not change and the date of
event and RIT are maintained.
Notes:
• A patient may have negative cultures during the RIT without impact on the RIT.
• Do not change the device-association determination during the RIT.
• Do not change location of attribution determination during the RIT.
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(Refer to Appendix B, Secondary Bloodstream Infection (BSI) Guide of the BSI Event
Protocol)
The Secondary BSI Attribution Period*(SBAP) is the period in which a blood specimen must
be collected for a secondary bloodstream infection to be attributed to a primary site infection.
This period includes the Infection Window Period combined with the Repeat Infection
Timeframe (RIT). It is 14-17 days in length depending upon the date of event.
An NHSN site-specific definition must be met; either one of the CDC/NHSN Surveillance
Definitions for Specific Types of Infections (defined in Chapter 17), or UTI, PNEU or SSI
definition.
AND
Scenario 1: At least one organism from the blood specimen matches an organism
identified from the site-specific infection that is used as an element to meet the NHSN
site-specific infection criterion and the blood specimen is collected in the secondary
BSI attribution period.(infection window period + repeat infection timeframe).
OR
*Notes:
• When meeting the Endocarditis (ENDO) definition, the secondary BSI attribution
period includes the 21-day infection window period and all subsequent days of the
patient’s current admission.
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A BSI is considered secondary to NEC if the patient meets one of the two NEC
criteria AND an organism identified from blood specimen collected during the
secondary BSI attribution period is an LCBI pathogen, or the same common
commensal which is identified from two or more blood specimens drawn on separate
occasions collected on the same or consecutive days.
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In the example below (Table 7), the Date of Event is hospital day 4. The 14-day RIT is
hospital day 4 through day 17. The Secondary BSI Attribution Period is the Infection
Window Period combined with the Repeat Infection Timeframe (RIT), 17 days in this
example. The blood culture collected on hospital day 10 has a matching pathogen to the site-
specific culture used to meet SUTI definition, and therefore, a secondary BSI is identified.
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In the example below (Table 8), the Date of Event is hospital day 4. The 14-day RIT is
hospital day 4 through day 17. The secondary BSI Attribution Period is 17 days in length.
The blood culture collected on hospital day 5 is used as an element to meet the PNU2
infection definition and therefore a secondary BSI is identified.
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The following provides guidance for reporting pathogens associated with site-specific
infections that are identified during the RIT or during the secondary BSI attribution period.
• Additional eligible pathogens recovered during the RIT from the same type of infection
are added to the event.
• Report all site-specific pathogens before secondary BSI pathogens.
o SUTIs can only have two organisms entered according to NHSN application
rules. However, if yes is selected for the secondary BSI field, the third pathogen
field will become available for data entry.
• If at least one BSI pathogen with a collection date in the secondary BSI attribution period
matches organism from a specimen (either a site-specific specimen or a blood specimen)
that was used to meet a site-specific infection criterion additional eligible BSI pathogens
are also considered secondary to the event.
• BSI pathogens may be assigned to more than one infection source at the same time in the
following scenarios.
1) Secondary BSI pathogen assigned to two different site-specific infections (see
Example 1)
OR
2) Secondary BSI pathogen assigned to a site-specific infection and assigned as
pathogen to a primary BSI event (see Example 2).
Example 1:
Note: As per the SSI protocol, the SSI-IAB does not have an Infection Window Period or
RIT. The secondary BSI attribution period is 17 days in duration including the date of
event, 3 days prior and 13 days after the date of event.
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Cont. Example 1
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Example 2:
On day 4 of hospital admission, S. aureus is identified in a blood culture
meeting the HAI, LCBI 1 criterion. On day 8 the patient has a fever > 38.0° C
and E. coli is identified in a urine culture meeting the SUTI definition. On
hospital day 13, a blood culture positive for E.coli is identified. Because the
blood culture occurs within both the LCBI RIT and the SUTI secondary
BSI attribution period, the pathogen, E.coli is assigned to both events.
• Pathogens excluded from specific infection definitions (for example. yeast in UTI, or
Enterococcus spp. in PNEU) are also excluded as pathogens for BSIs secondary to that
type of infection (specifically they cannot be added to one of these infections as a
pathogen). The excluded organism must be accounted for as either:
1) A primary bloodstream infection (BSI/CLABSI) (see Example 3)
OR
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Example 3:
A SUTI with Enterococcus faecalis is identified and a subsequent blood culture
with yeast and E. faecalis is collected during the SUTI secondary BSI attribution
period. A BSI secondary to SUTI is identified. E. faecalis is already
documented as a pathogen, but the yeast will not be reported as a secondary
BSI pathogen, because yeasts are excluded as organisms in the UTI
definition. In this example, no other primary source of infection for which the
yeast BSI can be assigned as secondary is identified. Therefore a primary BSI
with yeast only is identified.
Note: The Enterococcus faecalis is not assigned as a pathogen for the primary
BSI because if an excluded organism had not been identified, a primary BSI
would not have been reported.
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Example 4:
A PNU2 with Acinetobacter baumannii cultured from blood is identified.
Note: the positive chest imaging result is the diagnostic test that is used to
define the infection window period. A subsequent blood culture with
Enterococcus faecalis and A. baumannii is collected during the secondary BSI
attribution period of this PNU2 event. Enterococcus faecalis will not be
reported as a pathogen for the PNU2, because Enterococcus spp. are
excluded as organisms in the PNEU definition. Another primary source of
infection, SUTI, is found and Enterococcus faecalis is assigned as a secondary
BSI pathogen.
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• Determination of a secondary BSI to a primary site of infection does not set an RIT for
all subsequent BSIs. If a blood culture occurs during a site specific infection’s secondary
BSI attribution period and it cannot be used as an element to meet the infection definition
or does not have at least one matching pathogen to the site-specific infection culture used
to meet the site-specific infection criterion the BSI must be evaluated as a new BSI event
(see Example 5)
Example 5:
A SUTI with Enterococcus faecalis is identified and a blood culture with E.
faecalis collected on hospital day 11 within the SUTI secondary BSI
attribution period is also identified. On hospital day 15 (also within the SUTI
RIT and secondary BSI attribution period), a blood culture growing
Staphylococcus aureus is identified. Because the blood growing S. aureus
does not have at least one pathogen that matches the urine culture used to
meet the SUTI criterion the BSI cannot be attributed as secondary to the
SUTI. The BSI will need to be investigated as a new BSI event and either
assigned as a secondary BSI to another primary site of infection or determined
to be a primary BSI.
Note: The secondary BSI attribution period for a primary site of infection does
not establish a repeat infection timeframe for all subsequent BSIs.
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• When identifying a BSI which appears to fall within a BSI-RIT, it is important to verify
the initial BSI was indeed a primary BSI and not a secondary BSI to site-specific event.
Only primary BSIs create a BSI RIT, therefore, incorrectly establishing a BSI-RIT for a
secondary BSI event can result in the inaccurate assignment of a BSI pathogen(s) and the
identification of a true CLABSI event will likely be missed (see Example 6).
Example 6:
Initially a BSI was identified as POA and therefore not further investigated. Upon
identification of a subsequent BSI it cannot be assumed that the POA BSI set a BSI
RIT. Instead, it must be verified that the initial BSI was indeed a primary BSI and
not a secondary BSI to a site-specific infection. In the example below, upon further
review the initial BSI was actually determined to be a secondary BSI to a SKIN
infection. The SKIN Secondary BSI Attribution Period does not capture all
subsequent BSIs. In this example it can only account for BSIs that have at least one
matching pathogen to the site-specific specimen (wound drainage) used to meet
SKIN. The BSI on hospital day 9 does not match and it also was determined not to be
secondary to another site-specific infection and therefore a CLABSI is identified.
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The inpatient location where the patient was assigned on the date of event is the location of
attribution (see Date of Event definition). Non-bedded patient locations, (for example,
Operating Room (OR) or Interventional Radiology (IR)) are not eligible for assignment of
location of attribution for HAI events. Location of attribution must be assigned to a location
where denominator data (for example, patient days, device days) can be collected.
Transfer Rule: If the date of event is on the date of transfer or discharge, or the next day, the
infection is attributed to the transferring/discharging location. This is called the Transfer
Rule. If the patient was in multiple locations within the transfer rule time frame, attribute the
infection to the first location in which the patient was housed the day before the infection’s
date of event. Receiving locations or facilities should share information about such HAIs
with the transferring location or facility to enable accurate reporting. See examples below.
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Note: Surveillance after the patient is discharged from the facility is not required. However, if
discovered, any infection with a date of event (DOE) on the day of discharge or the next day is
attributable to the discharging location and should be included in any data reported to NHSN for
that location. No additional device days are reported.
Location Example:
Facility Example:
Multiple transfers within the same facility during the same admission Example:
In instances where a patient has been transferred to more than one location on the
date of an infection, or the day before, attribute the infection to the first location in
which the patient was housed the day before the infection’s date of event.
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Note: The complete set of CDC/NHSN HAI site-specific infection criteria, and the
comments and reporting instructions integral to the correct application of the criteria, can be
found in Chapter 17, CDC/NHSN Surveillance Definitions for Specific Types of Infections,
PNEU (Chapter 6), and UTI (Chapter 7).
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Identify the diagnostic test,
APPENDIX: Flow Diagram for NHSN Event Determination
or in the absence of a diagnostic test,
the localized sign/symptom that will
determine the Infection Window
Period (IWP)
Determine
the Date of Event
STOP (DOE) STOP
Yes Yes
Not an NHSN event Not an NHSN event
Is there a Is there a
UTI Repeat No Repeat
Infection No Infection Yes
Timeframe Is the DOE during Timeframe
(RIT) in place? the Healthcare- (RIT) in place
Determine if the for the same
associated Infection
infection is device- HAI POA event type?
(HAI) or Present on
associated
Admission (POA)
timeframe?
Yes
STOP
No new event is
found, add eligible
pathogens to the
STOP Determine the Determine the 14- original event
No new event is location of day Repeat Infection
found, add eligible attribution Timeframe (RIT)
pathogens to the
original UTI
If not a primary
bloodstream
infection (BSI),
determine the
Refer to the NHSN Patient Safety Component Manual, Secondary BSI
Chapter 2 for detailed guidance. Attribution Period
(SBAP)