Entrance Test For M.Sc. (Biotechnology) I May 2L, 2oll I
Entrance Test For M.Sc. (Biotechnology) I May 2L, 2oll I
Entrance Test For M.Sc. (Biotechnology) I May 2L, 2oll I
:
PAPER CODE
3
Centre of Exam. :
SERIESCODE
A
Name of Candidate :
S A U
I
I Entrance Test for M.Sc. (Biotechnology)
Candidates must read carefutlg the fottotuing instructions before attempting the
Question Paper :.
(i) Write your Name and Registration Number in the space provided for the purpose
on the top of this Question Paper and in the Answer sheet.
(ii) This Question Paper has Two Parts'
(iii) Part-A has 30 questions of 1 mark each.
(iv) Part-B has 120 questions out of which please attempt 70 questions only. Each
question carries 1 mark.
(ix) Pages at the end have been provided for Rough Work.
(x) Return the Question Paper and the Answer Sheet to the Invigilator at the end of
the Entrance Examination.
(xi) DO NOT FOLD THE ANSWER SHEET.
t3-A
INSTRUCTIONS FOR MARRING ANSWERS IN THE OMR SHEET
1. Use only Blue/Black Ballpoint Pen (do not use Pencil) to darken the Circle.
2. Please darken the whole Circle.
3. Darken ONLY ONE CIRCLE for each question as shown below in the example :
.-+
t3-A
PART-A
(b) 2xtoe bp
(c) 6xtoe bp
(d) 9xloe bp
3. Non-pigmented bacterial suspensions also show optical density in visible light, becduse
of
(a) absorption of light of specific wavelength
(b) refraction of specific wavelengths of light
(c) non-specific refraction of light
(d) scattering of light
4. The counts of bacteria per mL in samples withdrawn at two time points separated by
one hour in the exponential phase are ca 1.5x 108 and 6x 108, respectively. The
generation time of the bacterium should be
(a) I hour
(b) 4 hours
(c) j trour
(d)
{ hour
t3-A I P.T.o.
6. A restriction enzyrne recognizes four contiguous base pairs in DNA. What will be the
approximate frequency of its occurrence?
(b) Once in 3 kb
(c) Once in 10 kb
(a) monoc5rtes
(d) B cells
8. A father's age is the sum of the ages of his three sons. If the ratio of the ages of the sons
is 1 : 2 : 3 and eight years later the difference between the ages of the father and the
youngest son is 35 years, what is the current age of the eldest son?
(a) 30 years
(b) 28 years
(c) 21 years
(d) 24 yeats
lg-A 4
11. Human existence on the earth can be traced back to
(a) One
(b) TWo
(c) Three
(d) Four
(a) KMnOo
(b) BaSOo
(c) NarCrOo
(d) CuSOo
15. Which of the following molecules contains the. sho;test carbon-carbon bonds?
(a) CzHz
(b) czH+
(c) CaHa
(d) coHtz
l3-A I P.T.O .
16. Gregor Johann Mendel's experirnents with garden peas established that
(b) there is a quantitative pattern of inheritance traits that correlate with the traits of
paxents. This suggests for some material basis of inheritance
(c) those are the chromosomes that are passed on to next generation
(a) cell
(b) nucleus
(d) mitochondria
18. The non-covalent bonds in biological system have a free energr in which of the following
ranges?
(a) 0. I kcal/mole
19. How many decapeptide variants will result if during peptide synthesis, ten of the twent5r
amino acids are allowed to be incorporated randomly?
(a) 1o2o
(a) I atmosphere
(b) 2 atmosphere
(c) 5 atmosphere
(d) 1O atmosphere
/3-A 6
2L, Nitrogen liquefies at
(a) - 196 K
(b) - 196'C
(c) 77 "F
(d) -273 K
(c) Mitochondria
(b) Herbivorousconsumers
(d) Decomposers
24. Which of the following cellular organisms has been revived by putting a synthetic
genome in ghost cells?
25, Who among the following scientists was responsible for adopting X-rays for clinical
imaging?
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26, If log" 9 =2, then x =
(a) 4.s
(b) 18
(c) 3
(d) 2
(a) Alanine
(b) Glutamine
(c) Tryptophan
(d) Cysteine
24. As brakes are applied in a car, books on the passenger seat suddenly fly forward. That
is most likely, because
(b) the seat supplies a forward push to make the books accelerate
(a) 3
(b) s
(c) 7
(d) e
l3-A 8
PART-B
31. Which of the following is closest to the number of different sequences in a pool of
random sequence 25-mer oligonucleotide?
(a) lor2
(b) lors
(c) 1o2o
(d) ro25
32. In a four-point (ABCD) cross between Hfr and F- strains of E. coli, the pair-wise
frequencies of recombination fell in the following order :
(b) ACDB
(c) ADCB
(d) ABDC
34. At low titres, adsorption of virions by host cells follows a Poisson distribution. If a
suspension of 106 virions is added to lO6 host cells, the number of cells that will
receive at least one virus particle would be close to
(c) 3.7x106
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35. A genetic signature is created, based on'6unlinked markers (a-f) with the frequeacies
(a) O'01, (b) 0'02, (c) 0'003, (d) 0'001, (e)O'OOaand (f) 0'05. The theoretical probability of
two individuals sharing this signature is
(a) holoblastic
(b) semi-holoblastic
(c) meroblastic
(a) viviparousreproduction
(b) ovoviviparousreproduction
(a) cerebellum
(b) tegmentum
(c) tectum
(d) pons
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39. Larvae of the crab genus Carcinus swim towards the water surface when pressut-e
increases. This is an example of
(a) photokinesis
(b) thigmokinesis
(c) barokinesis
(d) orthokinesis
(a) molluscs
(b) sponges
(c) rotifers
(a) cellulose
(b) lignin
(c) pectin
(d) retinol
42. The value of which of the following parameters is zero when the cell is fully tur$d?
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43. The edible part:of black pepper is
(a) aril
(b) perisperm
(c) embryo
(d) cotyledon
(c) tendril
(d) parietalplacentation
(d) legumes
(a) three
(b) four
(c) five
(d) six
/3-A L2
47. Among the E. colt DNA polymerases, which of the following haq. a 5',i.3' gxonuclease
activity?
(a) Pol5rmerase I
(b) Pol5rmerase II
(d) Polymerase e
44. Which of the following amino acids is found both'in:D and L forrns in peptidoglycan? '
(a) Alanine
(c) Glutamine
(d) Lysine
49. Which one of the following enzymes in mammalian cells is attached to ttrg membrane by
a GPl-anchor?
(a) Alkalinephosphatase
,(a) cD4
(b) cD8
(c) cD3
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51. Smallpox virus genome is a
(a) single-strandedDNA
(a) adenine
(b) c5rtosine
(c) guanine
(d) thymine
53. Which of the following operons is regulated by both repression and attenuation?
(d) p-Galactosidaseoperon
(a) 1 mm
(b) 0. 5 mm
(c) 0.05 mm
(d) O.Ol mm
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Transposons (jumping genes) were discovered by
(a) Temin
(b) Abelson
(c) Harvey
(d) McClintock
56. SDS-PAGE separates proteins mainly on the basis of mass and not charge, because
(b) neutral species can move in electrical field only on the basis of mass
(a) DNA
(b) RNA
(c) proteins
(d) carbohydrates
58. Which of the following subunits of E. coli RNA polymerase is essential for promoter
recognition?
(a) Alpha
(b) Beta
(c) Beta'
(d) Sigma
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59. Which of the following membranes'has the greatest ratio of lipid to protein?
(b) Myelin
(a) acetoacetate
(b) cholesterol
(c) palmitate
(a) Alanine
(b) Glycine
. ' '
62. Lyme disease is caused by the bacterium
(d) Bordetellnperfnsstis
/3-A 16
63. The haemoglobin chain that replaces the beta chain in embryonic haemoglobin is
(a) delta
(b) epsilon
(c) gamma
(d) alpha
^ (a) UAA
(b) UAG
(c) UGA
(d) uAc
(a) Mas
(b) Myc
(c) Src
(d) sip
(a) fishes
(b) microorganisms
(c) plants
(d) mammals
/3-A L7 I P.T.O .
67, Chlorophyll molecules in chloroplasts are located in
(4 stroma
(b) thylakoid
(a) AcG
(b) cuc
(c) GUG
(d) AAG
(a) eosin
(b) hematorylin
7o. Which of the following bacterial protein toxins is tlre most potent toxin?
(a) Botulin
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7L. The bases that can pair with inosine (in tRNA) according to the wobble hypothesis fre
(a) A, C and G
(b) A, C and U
(c) C, G and U
(d) A, G and U
(a) 16
(b) 17
(c) 18
(d) I
73. Fc and Fab fragments of IgG are produced upon digestion with
(a) chymotrypsin
(b) papain
(c) trypsin
(d) lysozyme
(a) biotin
(b) pyridoxalphosphate
(c) tetrahydrobiopterin
(d) albumin
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75. .Which one'of the following is riot a plant horrnone?
(c) Prephenate
(d) Zeatin
(a) fumarate
(b) oxaloacetate
(c) pynrvate
(d) rnalate
(b) Poliovirus
(c) Vaccinia
(d) Papillomavirus
(a) roots
(b) amyloplasts
(c) bacteroids
(d) chloroplasts
l3-A 20
79. Retroviral replication is prirneil by
(b) a tRNA
(a) r9s2
(b) 1es8
(c) 1966
(d) 1e68
(a) dimer
(b) monomer
(c) trimer
(d) tetramer
(a) albinism
(b) alkaptonuria
(c) phenylketonuria
(d) sickle-cellanaemia
/s-A ci I P.T.o.
83. The selection markers on the plasmid pbr322 confer resistance to
84. Ribotyping is
85. In protein structure, the cr-helix and B=pleated sheets are examples of
(b) secondarystructure
(a) B-Galactosidase
(b) Amylase
(c) Lipase
(d) Restrictionendonuclease
l3-A 22
87. The minimum size of an epitope is
90. Which of the following drugs is used for immunocompromising patients receiving
grafts?
(a) Streptomycin
(b) Cyclosporine
(c) Tetracycline
(d) Penicillin
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91. Suppose the density of a solid is D and its average atomic r-nassis M. Which of thp
following represents the average spacing between the atoms in the solid?
(a) D/M
(b) M /D
(c) (D/uflz
(d) (M/n1r/s
(b) 0
(d) 5m/s2, up
93. A mass hangs from an ideal spring. When the mass is set into oscillation with
amplitude of I cm, its frequency is 1O Hz.lf the amplitude is increased to 2 cm, the new
frequency will be
(a) 5 Hz
(b) 7 Hz
(c) LO Hz
(d) 2o Hz
94. ,Ttvo artificial bones.{solid cylindrical) are made of the same rnaterial and length; one
with twice the radius as the other. When the two have the same tension force applied,
the larger bone stretches by what factor compared to the smaller bone?
(a) 2
(b) o.2s
(c) 0.5
(d) 4
/3-A 24
95. Ttvo identical blocks of mass m are tied together (by a light cord) and pulled up a rough
inclined plane at constant speed by a pulling force F directed along the incline and
applied to the upper block. Which of the following statements is true?
(a) The work done by F is zero because the blocks move at constant speed
(b) The total friction force must equal F because the blocks move at constant speed
(c) The tension in the cord is F because dhe two blocks are identical
(d) The work done by F is equal in magnitude to the work done by gravity plus the
work done by friction
(c) the magnitude of the change in momentum of the bird divided by the collision time
equals the magnitude of the average force on the jet
(a) - li.lc
(b) - bu
(d) zero
(c) cavitation
(d) scanning
/3-A 25 I P.T.O.
gg. The equipotential surfaces around a long straight wire with a uniform charge/length
are concentric
(a) spheres
(b) cylinders
(c) triangles
(d) planes
1OO. "The current in a resistor is directly proportional to the potential difference across the
resistor." It is known as
1O1. If the first-order double-slit diffraction minimum lies at the same place as the
fourth-order interference maximum, how many fringes will be visible in the central
diffraction maximum?
(a) 3
(b) s
(c) 6
(d) 7
l3-A 26
1O3. According to Bohr's theory, when a hydrogen atom makes a transition from n =5 to
n = 2 state, the average radial distance of the electron from the nucleus changes by
(a) 3 rr
(b) 25 r,
(c) 2l r,
(d) 5 rr
(b) continuousspectrum
(a) an insulator
(b) a metal
(c) a superconductor
(d) a plasma
t3-A 27 IP.T,O.
1O7. In the equilibrium state, AG is
(a) positive
(b) negative
(c) zero
1O8. Current in a circuit becomes wattless when phase transition between current and
voltage is
(a) zero
(b) n /2
(c) +n
(d) - TE
11O. If a certain polymer has the formula (-CH2CCI2CH2CC|2-1,.,, then from which
monomer is it made?
(a) Hc-tcl
(b) clHc-cclH
(c) CI2C4}I2
(d) H2C:CCIH
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111. The nitrite ion (NOl) may be represented by two major resonance forms. The lengths of
the nitrogen-to-oxygen bonds in this ion are expected to be
lL2. How should a student prepare 100 mL of a 1.0 M H2SO* solution from a 10M H2SO4
solution?
113. Which of the following pairs of gases has the same average rate of diffusion at 25 'C?
(a) He and Ne
(b) N, and O,
(a) AH<0
(b) aH>0
(c) AG< 0
(d) aG>0
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115. How many valence electrons are there in one ion of thiosulfate, S2o3-?
(a) 26
(b) 28
(c) 30
(d) 32
(b) sec-l
(c) sec/mol
LL7. The temperature at which a real gas obeys the ideal gas laws over a wide range of
pressure is called as
(a) Boyle'stemperature
(b) criticaltemperature
(d) inversiontemperature
(a) o
(b) I
(c) 2
(d) 3
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119. The last element in uranium decav series is
(a) lead
(b) platinum
(c) plutonium
(d) bismuth
(a) 3
(b) 6
(c) e
(d) 1
l2t. Rank the enthalpies of fusion, sublimation and vaporization for water.
122. Which of the following statements about the radii of atoms and their ions is correct?
(a) Cations are smaller than their atoms, but anions are larger
(b) Cations and anions are both smaller than their atoms
(c) Cations and anions are both larger than their atoms
(d) Cations are larger than their atoms, but anions are smaller
/3-A 31 I P.T.o.
LZg, What would be the coeflicients x, a, z, respectively, in order to balance tne fJtouiing
equation?
xCuHrrOu + gCrHrOH+ zCO,
(a) 1,2,2
(b) 1, 3, 3
(c) I, l, 4
(d) 2, 4,2
124. The process in which fine particles clump together to form flakes is called
(a) precipitation
(b) peptization
(c) flocculation
(d) extraction
l2S, Which of the fotrlowing properties of liquid does not increase with increasing strengths of
intermolecular forces?
(d) Viscosity
/3-A 32
LZ7. Which of the following techniques can be used todetermlne the number of componefts
in a plant pigment?
(a) Calorimetry
(b) Chromatography
(c) Colorimetry
(d) Gravimetry
!29. Which of the following functional groups is not commenly found in proteins?
(a) Alcohol
(b) Aldehyde
(c) Amide
(d) Amine
13O. What is the position of the bromine atom relative to the methyl group in
3-bromotoluene?
(a) meta
(b) ortho
(c) para
(d) trans
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131. An s-32p-CTP preparation has a specific radioactivity of 400 Ci per millimole]It has
been aliquoted as 10 pci per pL. The amount of crp in each pL in this aliquot would be
(b) 25 pmoles
(c) 25 pmoles
(d) 40 pmoles
(a) alcohol
(d) benzene
(b) holding the transition state for longer time than in an unaided reaction
(c) not letting the product undergo a reverse reaction and regenerate the substrate
134. Which of the following parts of nucleic acid has/have maximal hydrophobicity?
l3-A 34
135. The conversion of Rl-CO-R2 into (R1, R2, R3)-C-OH can be accomplished b;f-
136. Rate of sedimentation depends on applied centrifugal field (G) which is directed
outward, angular velocity coand the radial distance r of the particle from the axis of
rotation. Which of the following equations correctly describes the relationship among
the three?
(a) G = ro2r
(b) a= G2r
(c) G = ar2
(d) G=a/12
137. Covalent bonds can either stretch or bend. If a molecule has n atoms, then it will have
(3n - 6) fundamental vibrations in total. Out of (3n - 6) vibrations, how many of them will
be stretching vibrations?
(a) n-l
(b) 2n-r
( c ) 2 n- 5
(d) 3n- 5
138. The reagent, you would use to measure steroids by colorimetric methods, is
(b) Liebermann-Burchardreagent
t3.-A 35 lP.T.O.
139. Which of the following compounds is used for separation of cells by density gradient
methods?
(c) Ficoll
(d) Glycerol
14O. Passing of charged particle through a gas causes ionization of the atoms of the gas. i
Which of the followirrg correctly represents the ability to induce ionization in increasing
order?
(a) c>F>T
(b) F>cr>y
(c) y>p>cx
(d) y>cr>B
L4l. The first five terrns of the sequencedefined inductively €lsu, = l and u* + L = uk + 2k are
(a) L, 3, 7, 15,31
(b) 1, 3, 5, 9, 17
(c) 3, 7, 15,31, 63
(d) 3, 5, 9, L7, 32
c
L42. For large values of n" the value "- : tends to
"f n + l
(a) €
(b) 0
(c) I
l3.-A 36
143. For the functibn f :x+x2 t^rithdomain x:-3S.xS3, what is the range?
(a) {y:0<a<9}
(c) la,-9<a<9\
(d) {y:y<3}
(a) El and E2
(b) El only
(c) E2 only
145. The mean of a data set is equal to L2 and its standard deviation is equal to 1. If we add
4 to each data value, then the mean and standard deviation become
L46. What number must be added to A= x3 +5x2 +lox+1to make (x+1) a factor?
(a) 10
(b) 1
(c) s
(d) 3
/3-A 37 lP.r.o.
147. At what points does the graph of g=2x3 -6x2 equally reach a maximum and a
minimum?
148. Given logro 100 = logro lo2 =2, what is the value of lo9164?
(a) 6.0
(b) 2.3
(c) 1.s
(d) 4 .o
(a) I
(b) 0. s
(c) 0.3
(d) 2
x]/[1+ sec(x]lis
15O. [sec(x)sin2
(a) r.0
(b) .tr
(c) Jz
(d) 1- cos x
***
l3-A 38
SPACE FOR ROUGH WORK
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SPACE FOR ROUGH WORK
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SPACE FOR ROUGH WORK
l3-A 4T et11-800