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    Paracetamol Elixir

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    Ken Laguiab
    1. The document describes producing a paracetamol elixir, which is a clear, sweet-flavored liquid used orally to cure illness. 2. Paracetamol elixir contains 120 mg of paracetamol as the active ingredient, along with glycerol, propylene glycol, sorbitol solution, ethanol, and other ingredients to solubilize and dilute the paracetamol. 3. The elixir is used to treat mild or moderate pain and fever in babies and children, including after vaccination.

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    © All Rights Reserved
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    Paracetamol Elixir

    Uploaded by

    Ken Laguiab
    1K views16 pages
    1. The document describes producing a paracetamol elixir, which is a clear, sweet-flavored liquid used orally to cure illness. 2. Paracetamol elixir contains 120 mg of paracetamol as the active ingredient, along with glycerol, propylene glycol, sorbitol solution, ethanol, and other ingredients to solubilize and dilute the paracetamol. 3. The elixir is used to treat mild or moderate pain and fever in babies and children, including after vaccination.

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    1. The document describes producing a paracetamol elixir, which is a clear, sweet-flavored liquid used orally to cure illness. 2. Paracetamol elixir contains 120 mg of paracetamol as the active ingredient, along with glycerol, propylene glycol, sorbitol solution, ethanol, and other ingredients to solubilize and dilute the paracetamol. 3. The elixir is used to treat mild or moderate pain and fever in babies and children, including after vaccination.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    1K views16 pages

    Paracetamol Elixir

    Uploaded by

    Ken Laguiab
    1. The document describes producing a paracetamol elixir, which is a clear, sweet-flavored liquid used orally to cure illness. 2. Paracetamol elixir contains 120 mg of paracetamol as the active ingredient, along with glycerol, propylene glycol, sorbitol solution, ethanol, and other ingredients to solubilize and dilute the paracetamol. 3. The elixir is used to treat mild or moderate pain and fever in babies and children, including after vaccination.

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    © All Rights Reserved
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    GROUP 2

    Paracetamol
    Elixir
    1. Produce clear, flavoured, liquid preparations known as
    elixirs, compatible to procedures learned.
    2. Confidently recommend the use of the product they make.
    Paracetamol Elixir

    SYNONYM: ACETAMINOPHEN ELIXIR

    ELIXIR is a clear, sweet-flavored liquid used for medical


    purposes, to be taken orally and intended to cure one's illness.
    When used as a pharmaceutical preparation, an elixir
    contains at least one active ingredient designed to be taken
    orally.

    Paracetamol Elixir can be used in babies and children for the


    treatment of mild or moderate pain and feverishness, and
    also in babies who develop fever after vaccination.
    INGREDIENTS WEIGHT FUNCTION
    PARACETAMOL 120 mg ACTIVE
    INGREDIENT
    GLYCEROLUM 2.5 mL SOLUBILIZER

    PROPYLENE 0.5 mL DILUENT

    Ingredients
    GLYCOL
    SORBITOL 1.25 mL SWEETENING
    SOLUTION
    ETHANOL 0.5 mL DILUENT

    FLAVORING q.s.
    AGENT
    COLORING q.s.
    AGENT
    PRESERVATIVE q.s.

    PURIFIED q.s.
    WATER
    PARACETAMOL SOLUBILITY

    Soluble in 70 parts of water and in 7 parts 95% Ethanol P, in 13 parts of acetone P, in 40 parts
    of glycerol P, and in 19 parts of propyleneglycol P, soluble in alkali hydroxide solution.

    sorbitol

    Is hygroscopic, easily soluble in water and sparingly soluble in ethanol

    propyleneglycol

    Can be mixed with water and ethanol 95%

    glycerol

    Can be mixed with water and ethanol


    W hy is solubility data very useful?

    Solubility data is very useful in preparations, which include the


    sequences or a mix of each ingredient must be strictly in
    accordance with the nature and solubility. If seen from the
    solubility then we know that the function of glycerol and
    propylenglycol is to enhance the solubility of the medicine that is
    useful to maintain the stability of the drug.
    STANDARD DOSE:
    CHILDREN UP TO 1 YEAR = 1 tsp (5 mL)
    1-5 YEARS = 2 tsp (10 mL)
    Data and
    Results
    INGREDIENT WEIGHT/VOLUME
    PARACETAMOL 0.12g
    GLYCEROLUM 2.5 mL
    PROPYLENE GLYCOL 0.5 mL
    SORBITOL SOLUTION 70% 1.25 mL
    ETHANOL 0.5 mL
    UBE FLAVOR 1 mL
    COLORING AGENT (VIOLET) 1 pinch
    BENZOIC ACID 2 mL
    PURIFIED H2O 52.25 mL -> 53 mL
    Conclusion
    In conclusion the purpose of this experiment is to produce a clear
    flavored liquid preparation known as elixirs that is compatible to the
    procedures that is learned. And to confidently recommend the used of
    product that we have made which is the paracetamol elixir.
    Paracetamol elixirs are used in babies and children for the treatment of
    mild or moderate pain and feverishness, and also in babies who
    develop fever after vaccination. The importance of elixirs are usually to
    mask the unwanted taste of active ingredients, which is helpful in
    administering to children.
    Learning
    Evaluation
    What are the primary solvents of elixirs?
    The primary solvents of elixirs are alcohol and water, with glycerin, sorbitol
    and syrup sometimes as an additional solvent and as sweetening agent

    WHAT ROLE DO GLYCERIN AND PROPYLENE GLYCOL PLAY IN ELIXIRS?

    They are commonly used in Elixirs as ADJUNCTIVE SOLVENTS

    WHAT ARE THE TYPES OF ELIXIRS AND HOW ARE THEY PREPARED?

    High Alcoholic Elixir (75% to 78% alcohol)


    Low Alcoholic Elixir (8% to 10%)
    Elixirs are usually prepared by simple solution with agitation and/or by
    admixture of two or more liquid ingredients. Alcohol soluble and water
    soluble components are generally dissolve separately in alcohol and in
    purified water respectively

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