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Implications For Secretion Clearance

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Implications for Secretion Clearance

Presented by: Tania Larsen, PT, PhD


London Health Sciences Centre
Western University
London, Canada
Outline
1. What is obstructive disease?
1. Definition
2. Characteristics
2. Factors to consider with respect to secretion
clearance
1. Airway resistance
2. Mechanisms limiting airflow
3. Evidence-informed secretion clearance options for
people with obstructive disease
Airway Obstructive Disease
‘those that interfere with airflow’

conducting zone

alveolus

• Limitation to airflow in
the conducting zone
(tracheobronchial tree)

Photo taken from : https://asthmawa.org.au/new-airphysio-device/


Clinical Diagnostics: Pulmonary Function Tests
used to distinguish 2 broad categories of disorders

Obstructive Restrictive
conducting zone

alveolus parenchyma
alveolus

impediment to airflow in expansion of lung restricted either


conducting zone of lung because of alterations in the lung
(tracheobronchial tree) parenchyma or because of disease of
the pleura, or dysfunction of the
respiratory pump **
Characteristics of Obstructive Disease
• High resting lung volumes
• Lower inspiratory & expiratory volumes
• Low flow rates

FEV1/FVC
FEF25-75%

• Difficulty getting air out (air trapping)


• Limitation of expiratory airflow

Photo taken from: https://step2.medbullets.com/pulmonary/120664/pulmonary-function-tests


Review of Factors that Affect Airflow
 Airway Resistance
 Size of airways
 Big ‘O’ versus little ‘o’

 Chief site of airway resistance


 Bronchus (medium sized airways)

Image taken from: https://www.researchgate.net/figure/Location-of-the-chief-site-of-airway-resistance-Note-that-the-intermediate-sized-bronchi_fig6_49583713


Review of Factors that Affect Airflow
 Airway Resistance
 Dynamic Airway Closure

Equal Pressure Point (EPP)

narrowing of the airway on


expiration beyond EPP

Image taken from: http://www.pathwaymedicine.org/airflow-resistance


Review of Factors that Affect Airflow
 Airway Resistance
 Airway obstruction
 Mucous, swelling, bronchospasm +/- collapsible airways

Image taken from: http://www.pathwaymedicine.org/airflow-resistance


Mechanisms of Airflow Limitation
Obstructive Disorders

* emphysema
asthma

chronic bronchitis
cystic fibrosis

* normal ageing associated with gradual breakdown of elastic tissue


*slide credit SD Lucy
Mechanisms Underlying Airflow
Limitation in COPD
Bronchi
Mucous gland hypertrophy
and hyperplasia
Thickened walls →
decreased lumen size
Increased airway resistance
Bronchioles Parenchymal Destruction
Airway inflammation and
Loss of alveolar attachments
fibrosis
Luminal mucous plugs Loss of bronchiolar support
Increased airway resistance Decrease of elastic recoil

Airflow
Limitation
Let’s Recap….
 Limitations to airflow
 Secretions, inflammation, dynamic airway compression
+/- collapsible airways
 Low expiratory volumes and flow rate

 Why is airflow important?


 It’s what moves secretions
Obstructive Disease
 Cystic fibrosis
 Bronchiectasis
 COPD with secretions
 Asthma with secretions
 Ciliary dyskinesia

 Characterized by impairments primarily in expiratory


volumes and flow rates
 Goal is to get air behind secretions and optimize
expiratory flow rates to move secretions
Considerations for Secretion Clearance

Image taken from: Gosselink et al., 2008


Considerations for Secretion Clearance

• Ensure sufficient inspiration to allow air to enter and get


behind the secretions

• Limit airway resistance – maximize size of ‘o’ on expiration


• Maximize expiratory flow rate
Image taken from: Gosselink et al., 2008
Secretion Clearance Guidelines

Thorax, 2009

Eur Respir Rev, 2017

Respiratory Care, 2013


Evidence-informed Secretion
Clearance for People with
Obstructive Disease
1. Cough/Huff
2. PEP/Flutter
3. Active Cycle Breathing Technique
4. Autogenic Drainage
Increasing Expiratory Flow Rate
Cough Huff
 Deep inspiration (> TV)
 Deep inspiration
 Glottis closes
 Forced expiration through
 ↑ intrathoracic pressure open glottis
 Glottis opens  Ha, Ha, Ha
 Rapidly expelled volume of
air
No compression phase and thus
Premature airway closure in stabilizes collapsible airway walls
patients with collapsible airways
 Less airway resistance in
 Clears large airways expiration, bigger ‘o’
 Major bronchi compressed to  Expiratory flow slowly
½ size pushes secretions cranially
PEP
What?
 Low Pressure
 10-20 cm H2O

 High Pressure
 40-100 cm H2O

 Oscillating PEP/Flutter
PEP
 Why?
 Expiration against a resistor :

1. Avoids airway compression during expiration and so airways


are splinted open to increase expiratory flow and assist in
mobilizing secretions

2. Increases intrathoracic pressure distal to retained secretions


thus allowing air to move behind secretions via collateral
ventilation and increased FRC

 Who?
 People with Obstructive disease
PEP: How?
E.g, - product specific
 Inspiration
 Inspire through mask/mouth piece to normal or slightly above
TV

 Expiration
 Expire (slightly active) through mouth against the resistor to
create back pressure to normal level of expiration

 Repeat 12-15 breaths then remove mask


 Huff/Cough to clear secretions
 Repeat 5-6 cycles or until no more secretions
Active Cycle Breathing
 What?
 Active cycle breathing techniques incorporate breathing
control, thoracic expansion exercises and huffing
 Breathing exercises at TV or above

 Why?
 to mobilize and clear bronchial secretions

 Who?
 Obstructive disease, secretions obstructing airways
Active Cycle Breathing
How?
Breathing Control (BC)– diaphragmatic breathing at normal volume
(relaxed breathing, cue no shoulder movement)
Thoracic expansion (TEE) – deep inspiration (cue lateral costal expansion)
with unforced expiration
Forced Expiratory Technique (FET) - Huff

•Incorporate 3 second breath


hold to treat atelectasis and get
air behind secretions

•Incorporate huffing at different


lung volumes to move secretions
up airways
BC = 3 – 4 breaths
•Cough to clear secretions once TEE = 3 – 4 breaths
in large airways Huff = 1- 2 huffs
Image taken from: https://bronchiectasis.com.au/physiotherapy/techniques/the-active-cycle-of-breathing-technique
Autogenic Drainage
 What?
 Breathing technique is to achieve the highest possible
expiratory flow simultaneously in different generations
of bronchi, keeping bronchial resistance low, and
avoiding bronchospasm and dynamic airway closure
 Why?
 Optimizes speed of expiratory flow mobilises secretions
by shearing them from the bronchial wall and moving
them from peripheral airways to the mouth
 Who?
 Obstructive disease
Autogenic Drainage
 How?
 By adjusting lung volumes ERV → IRV

 Position
 Sitting or lying

 Inspiration
 Breathe in slowly through the nose and hold for 2-4 seconds
(diaphragmatic breathing)

 Expiration
 An active sigh through open glottis with appropriate airflow to avoid
abnormal airway compression
How?
Phases of Autogenic Drainage
Let’s Recap
 All secretion clearance techniques are not created
equal!

 To optimize effectiveness, secretion clearance


techniques should be tailored to type of lung disease
 Obstructive vs Restrictive
References
1. Physiotherapy for Cardiac and Respiratory Problems. Pryor JA & Prasad SA.
3rd Ed 2002. Churchill Livingstone.
2. Pulmonary Physiology. Levitsky MG. 7th Ed. 2007. McGraw Hill
3. Respiratory Physiology – the essentials. West JB. 4th Ed. 1990. Williams &
Wilkins.
4. Principles of Pulmonary Medicine. Weinberger SE. 3rd Ed. 1998. Saunders
5. Gosselink et al. “Physiotherapy for adult patients with critical illness:
recommendations of the European Critical Care Society of Intensive Care
Medicine Task Force on Physiotherapy for Critically Ill Patients”. Intensive
Care Medicine. 2008. 34:1188-1199.
6. Strickland et al. 2013. Respiratory Care, Vol 58(12)
7. McIlwaine et al. 2017. Eur Respir Rev, Vol 26.
8. Bott et at al., Joint BTS/ACPRC Guidelines. 2009. Thorax. Vol 64 (Suppl 1)
9. Agostini P, Knowles N. “Autogenic drainage: the technique, physiological
basis and technique”. Physiotherapy. 2007. 93(2): 157-63.

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