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    G6PD Deficient RBC

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    JR Betonio
    The document discusses red blood cells that are deficient in glucose-6-phosphate dehydrogenase and how this leads to ineffective detoxification of oxidative stress, damage to proteins and lipids, formation of Heinz bodies, membrane damage, and hemolysis.

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    G6PD Deficient RBC

    Uploaded by

    JR Betonio
    18 views1 page
    The document discusses red blood cells that are deficient in glucose-6-phosphate dehydrogenase and how this leads to ineffective detoxification of oxidative stress, damage to proteins and lipids, formation of Heinz bodies, membrane damage, and hemolysis.

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    G6PD deficient RBC

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    The document discusses red blood cells that are deficient in glucose-6-phosphate dehydrogenase and how this leads to ineffective detoxification of oxidative stress, damage to proteins and lipids, formation of Heinz bodies, membrane damage, and hemolysis.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    18 views1 page

    G6PD Deficient RBC

    Uploaded by

    JR Betonio
    The document discusses red blood cells that are deficient in glucose-6-phosphate dehydrogenase and how this leads to ineffective detoxification of oxidative stress, damage to proteins and lipids, formation of Heinz bodies, membrane damage, and hemolysis.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
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    Friday,

    January 31, 2020 8:25 PM

    G6PD deficient RBC

    Insufficient production of NADPH

    Impaired reduction of glutathione

    Ineffective detoxification of cell to oxidative stress

    Damage to protein, lipids, affecting Hg and cell membrane Conversion of sulfhydryl


    and disulfide bridges in Hg
    polypeptides

    Decrease solubility & precipitation


    forming Heinz bodies

    Heinz bodies adhere


    to RBC membrane

    Irreversible membrane damage

    Rapid removal of RBC with


    Heinz bodies in the circulation

    HEMOLYSIS

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