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    Drugs Pharmacokinetics Indications Contraindicatio N Interaction Adverse Effects Generic Name

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    JR Betonio
    Carbapenems like imipenem, meropenem, and doripenem are broad-spectrum beta-lactam antibiotics primarily absorbed in the kidneys and used to treat infections like UTIs, RTIs, intra-abdominal infections, and nosocomial infections. They have a short half-life of around 1 hour. Aztreonam is a monobactam antibiotic administered intravenously that is only active against gram-negative bacteria. Beta-lactamase inhibitors like clavulanic acid, sulbactam, tazobactam, and avibactam are used to inhibit plasmid-encoded beta-lactamases and expand the activity of other

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    Drugs Pharmacokinetics Indications Contraindicatio N Interaction Adverse Effects Generic Name

    Uploaded by

    JR Betonio
    27 views1 page
    Carbapenems like imipenem, meropenem, and doripenem are broad-spectrum beta-lactam antibiotics primarily absorbed in the kidneys and used to treat infections like UTIs, RTIs, intra-abdominal infections, and nosocomial infections. They have a short half-life of around 1 hour. Aztreonam is a monobactam antibiotic administered intravenously that is only active against gram-negative bacteria. Beta-lactamase inhibitors like clavulanic acid, sulbactam, tazobactam, and avibactam are used to inhibit plasmid-encoded beta-lactamases and expand the activity of other

    Original Title

    B-lactam

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    Carbapenems like imipenem, meropenem, and doripenem are broad-spectrum beta-lactam antibiotics primarily absorbed in the kidneys and used to treat infections like UTIs, RTIs, intra-abdominal infections, and nosocomial infections. They have a short half-life of around 1 hour. Aztreonam is a monobactam antibiotic administered intravenously that is only active against gram-negative bacteria. Beta-lactamase inhibitors like clavulanic acid, sulbactam, tazobactam, and avibactam are used to inhibit plasmid-encoded beta-lactamases and expand the activity of other

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    © All Rights Reserved
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    27 views1 page

    Drugs Pharmacokinetics Indications Contraindicatio N Interaction Adverse Effects Generic Name

    Uploaded by

    JR Betonio
    Carbapenems like imipenem, meropenem, and doripenem are broad-spectrum beta-lactam antibiotics primarily absorbed in the kidneys and used to treat infections like UTIs, RTIs, intra-abdominal infections, and nosocomial infections. They have a short half-life of around 1 hour. Aztreonam is a monobactam antibiotic administered intravenously that is only active against gram-negative bacteria. Beta-lactamase inhibitors like clavulanic acid, sulbactam, tazobactam, and avibactam are used to inhibit plasmid-encoded beta-lactamases and expand the activity of other

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    © All Rights Reserved
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    of 1

    PHARMACOKINETICS INDICATIONS CONTRAINDICATIO ADVERSE

    DRUGS INTERACTION
    (with dosage) N EFFECTS
    ABSORPTION DISTRIBUTION METABOLISM EXCRETION

    Generic name:
    Impenem Bioavailability: UTI Nausea &
    Meropenem NOT absorbed Kidney Kidney 70% RTI Dosage modification Vomiting
    Doripenem ORALLY T1/2: 1 hour Intra-abdominal & with renal (Most
    common)
    ertrapenem Gyne infection insufficiency
    Onset:
    Duration of Cephalosporin- Seizure(high
    Classification: doses in CNS
    Carbapenems, Beta- action: rsistant nosocomial lesion)
    Lactam antibiotics Impenem(comb infection
    with Cilastation which
    inhibits impenem
    degradation by renal Emperical Tx
    Chemistry: contain
    fused B-lactam ring and a five-
    tubular dipeptidase) serious infections in
    member ring system that hosp. patients
    differs from penicillins because
    it is unsaturated and contains a
    Notes:
    carbon atom instead of the Meropenem: less active to g(+), more active to g(-), less likely to cause seizure, Preferred Tx of Meningitis when Carbanem is required.
    sulfur atom. Doripem: greater activity against some resistant isolates of Pseudomonas.
    Broader spectrum of activity
    than most other B-lactam Ertrapenem: longer half-life, allows ONCE-daily dosing, good against enterobacteriaceae and anaerobes, useful in intra-abdominal and Pelvic infections.
    antibiotic
    Generic name: IM/IM T1/2: 1.7 hour kidney Gram negative
    Aztreonam unaltered 6h if anephric bacteria only
    Classification:
    Monobactam 2g q 6-8h
    Generic name: For antibiotic
    Clavulanate resistant strains
    Sulbactam
    Tazobactam Most active against
    plasmid-encoded B-
    Avibactam
    lactamase(older B-
    lactamses, clavulanate,
    Classification: Sulbactam, Tazobactam)
    Beta-Lactamase Clavulanic acid: poor intrinsic antimicrobial activity, suicide inhibitors, well absorbed orally, combined with amoxicillin as oral preparation, and with
    inhibitors Ticarcillin as parenteral preparation.
    Sulbactam:IM/IV, combined with ampicillin and cepoferazone, high dosages to treat Multi-drug resistant Acinetobacter infections.
    Tazobactam: good activity against many plasmid b-lactamases, parenteral, combined with piperacillin and ceftolozane.
    Family:
    Avibactam: new drug under B-lactamase inhibitors, a Non-B-Lactam B-lactamase inhibitor, useful inhibition against narrow-spectrum, ESBL-type,
    chromosomal AmpC, and KPC-type B-lactamases(although not metallo-B-lactamases). Parenteral combination with ceftazidime.

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