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    This study compared the effects of telmisartan and amlodipine on blood pressure, lipid profiles, and blood glucose levels in Indian patients with hypertension. Over 6 months, telmisartan significantly reduced both systolic and diastolic blood pressure more than amlodipine. Telmisartan also significantly reduced fasting and post-prandial blood sugar levels, urinary protein levels, and had greater beneficial effects on metabolic parameters compared to amlodipine. The results suggest that besides lowering blood pressure more effectively, telmisartan provides additional benefits on metabolic profiles in hypertensive patients.

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    This study compared the effects of telmisartan and amlodipine on blood pressure, lipid profiles, and blood glucose levels in Indian patients with hypertension. Over 6 months, telmisartan significantly reduced both systolic and diastolic blood pressure more than amlodipine. Telmisartan also significantly reduced fasting and post-prandial blood sugar levels, urinary protein levels, and had greater beneficial effects on metabolic parameters compared to amlodipine. The results suggest that besides lowering blood pressure more effectively, telmisartan provides additional benefits on metabolic profiles in hypertensive patients.

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    This study compared the effects of telmisartan and amlodipine on blood pressure, lipid profiles, and blood glucose levels in Indian patients with hypertension. Over 6 months, telmisartan significantly reduced both systolic and diastolic blood pressure more than amlodipine. Telmisartan also significantly reduced fasting and post-prandial blood sugar levels, urinary protein levels, and had greater beneficial effects on metabolic parameters compared to amlodipine. The results suggest that besides lowering blood pressure more effectively, telmisartan provides additional benefits on metabolic profiles in hypertensive patients.

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    37 views2 pages

    Viewof 1 PDF

    Uploaded by

    Kumarsai Durusoju
    This study compared the effects of telmisartan and amlodipine on blood pressure, lipid profiles, and blood glucose levels in Indian patients with hypertension. Over 6 months, telmisartan significantly reduced both systolic and diastolic blood pressure more than amlodipine. Telmisartan also significantly reduced fasting and post-prandial blood sugar levels, urinary protein levels, and had greater beneficial effects on metabolic parameters compared to amlodipine. The results suggest that besides lowering blood pressure more effectively, telmisartan provides additional benefits on metabolic profiles in hypertensive patients.

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    7/30/2020 View of Comparative study of telmisartan and amlodipine to assess the effect on blood pressure, lipid profile and

    ofile and blood glucose level…

     Comparative study of telmisartan and amlodipine to assess the effect on blood pressure, lipid profile …

    Comparative study of telmisartan and amlodipine to assess the effect


    on blood pressure, lipid profile and blood glucose level in Indian
    hypertensive patients
    Tripathi N 1, Bohara S 2, Singh R.R. 3, Kumar A 4, Uraiya D 5, Dhoan P 6
    1Dr Neeraj Tripathi, Assistant Professor, Department of Medicine ex-junior resident BRD
    Medical College, Gorakhpur, 2Dr Sangita Bohara, Assistant Professor, Department of
    Pathology, 3Dr R. R. Singh, Associate Professor, Department of Medicine, 4Dr Anoop
    Kumar, Assistant Professor, Department of Medicine, 5Dr Pooja Dhoan, Assistant
    Professor, Department of Medicine; all authors are affiliated with Hind Institute of
    Medical Sciences, Safedabad, Barabanki, U.P, India

    Address for correspondence: Dr Sangita Bohara, Email: drsangitamamc@gmail.com

    Abstract

    Introduction: Hypertension is emerging as a major health problem and while treating a


    patient with hypertension it is not only necessary to control blood pressure but also treat
    the associated risk factors which lead to metabolic syndrome. Methods: A randomized
    comparative study was designed to evaluate the effect of telmisartan on blood pressure
    (BP), lipid profile and blood glucose levels in hypertensive patients. This was compared
    with amlodipine with 1:1 randomisation. BP>140mm Hg (systolic) and >90mm Hg
    (diastolic) as well as body mass index (BMI) was taken in consideration. Blood sugar
    levels, lipid profile and urine samples were collected for protein and sugar. These samples
    were collected at baseline (first visit) and after 6 months. Results: The mean value of
    systolic BP in telmisartan group decreased from baseline by 17.43% (p<0.001) and
    13.79% in diastolic BP (p<0.001). On comparing with amlodipine, telmisartan reduced
    mean systolic BP significantly more by 8.42% (p<0.001) and 5.59% (p<0.001) in diastolic
    BP. The mean fasting sugar level in patients with telmisartan group after 6 months was
    100.70mg% which decreased by 10.27% (p<0.01) from baseline The effect of post
    prandial sugar level in telmisartan group was a reduction of 5.57mg% from baseline
    (p<0.001). There was significant reduction in mean value of urinary protein from
    160.22mg% to 92.22 mg% (p<0.001). Conclusion: Besides significant reduction in BP,
    telmisartan also had beneficial effects on various metabolic parameters, where amlodipine
    was not effective. The salutary effects of telmisartan on the metabolic profile may be
    additional attribute beyond its established antihypertensive effect.

    Key words: Telmisartan, Amlodipine, Metabolic syndrome, Hypertension, Blood pressure

    Manuscript received: 14th August 2016, Reviewed: 24th August 2016


    Author Corrected: 8th September 2016, Accepted for Publication: 20th September
    https://ijmrr.medresearch.in/index.php/ijmrr/article/view/701/1259 1/2
    7/30/2020 View of Comparative study of telmisartan and amlodipine to assess the effect on blood pressure, lipid profile and blood glucose level…

    https://ijmrr.medresearch.in/index.php/ijmrr/article/view/701/1259 2/2

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