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(E) It Is Reduced in People With Diabetes: (C) Fluid Overload

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Which of the following does not form part of the glomerular filtration barrier?

(a) Endothelial cell fenestration


(b) Sub-endothelial space
(c) Glomerular basement membrane
(d) Podocyte foot process slit diaphragm
(e) Sub-podocyte space
2. Which of the following is false about angiotensin II?

(a) It causes vasoconstriction of the efferent arteriole


(b) It increases the amount of albumin filtered by the glomeruli
(c) It is increased in renal acidosis
(d) It increases aldosterone production
(e) It is reduced in people with diabetes
3. Which of the following does not affect the serum creatinine concentration in chronic kidney disease?

(a) Glomerular filtration rate

(b) Tubular secretory function

(c) Fluid overload

(d) Skeletal muscle mass

(e) Ethnic origin

4. Which of the following is not a typical symptom of kidney failure?

(a) Insomnia (d) Restless legs


(b) Hallucinations (e) Nausea
(c) Itching
5. Furosemide acts on which part of the nephron?

(a) Proximal tubule


(b) Descending limb of the loop of Henle
(c) Ascending limb of the loop of Henle
(d) Distal tubule
(e) Collecting duct
6. An 80-year-old lady was prescribed ramipril 10 mg daily. Which of the following suggests this drug
was adversely affecting her kidney function?

(a) High urea-to-creatinine ratio

(b) eGFR <15 ml/min/1.73 m 2

(c) Systolic blood pressure <110 mmHg

(d) An irritating dry cough

(e) Hypokalaemia

7. Which of the following is not nephrotoxic?

(a) Gentamicin
(b) Cadmium
(c) Metformin
(d) Lithium
(e) Orellanine
8. Which of the following does not indicate an increased risk of renal failure?

(a) Proteinuria

(b) High blood pressure

(c) Reduced glomerular filtration rate

(d) Interstitial fibrosis on kidney biopsy

(e) Macroscopic haematuria

9. Which of the following statements about contrast-induced nephropathy is true?

(a) It can be ameliorated by sodium chloride infusion before the procedure

(b) It often requires temporary dialysis

(c) It is commoner in women

(d) It is less likely with hyper-osmolar contrast medium

(e) Is it rare if the eGFR is >30 ml/min/1.73 m 2

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