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Vancomycin

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Drugs & Diseases

vancomycin (Rx)

Brand and Other Names:Vancocin, Firvanq

Classes: Glycopeptides

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Dosing & Uses

Adult Pediatric

Dosage Forms & Strengths

capsule

125mg

250mg

injectable solution

5mg/mL

injection, lyophilized powder for reconstitution

500mg

750mg

1g

5g

10g

kit, powder for oral solution (Firvanq)

3.75 g

7.5 g
10.5 g

15 g

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Staphylococcal Enterocolitis

Vancocin and Firvanq

Indicated for enterocolitis caused by Staphylococcus aureus (including methicillin-resistant strains)

40 mg/kg PO divided q6-8hr for 7-10 days; not to exceed 2 g

Clostridium difficile-associated Diarrhea

Vancocin and Firvanq

Indicated for the treatment of Clostridium difficile (C. difficile)-associated diarrhea

40 mg/kg PO divided q6-8hr for 7-10 days; not to exceed 2 g

Endocarditis

<1 month: 15 mg/kg followed by 10 mg/kg IV q12hr for neonates in first week of life and q8hr thereafter
up to 1 month of age; longer dosing intervals recommended in premature infants

>1 month: 10 mg/kg/day IV divided q6hr; individual dose not to exceed 1 g

Current AHA guidelines recommend using only for high-risk patients

Preoperative Antimicrobial Prophylaxis

GI and GU procedures: 20 mg/kg IV by slow infusion over 1 hour, beginning 1 hour before procedure
(with or without gentamicin 1.5 mg/kg; not to exceed 120 mg IV or IM <30 minutes before procedure)

Bacterial Meningitis

15-20 mg/kg IV q6hr


Other Infections

40 mg/kg/day IV divided q6hr

Dosing Considerations

Neonatal dosing

<7 days and <1.2 kg: 15 mg/kg IV once daily; monitor serum levels and adjust dose

<7 days and 1.2-2 kg: 10-15 mg/kg IV q12-18hr; monitor serum levels and adjust dose

<7 days and >2.1 kg:: 10-15 mg/kg IV q8-12hr; monitor serum levels and adjust dose

>7 days and <1.2 kg: 15 mg/kg IV q24hr; monitor serum levels and adjust dose

>7 days and 1.2-2 kg: 10-15 mg/kg IV q8-12hr; monitor serum levels and adjust dose

>7 days and >2.1 kg: 15-20 mg/kg IV q8hr; monitor serum levels and adjust dose

Next: Interactions

Medscape prescription drug monographs are based on FDA-approved labeling information, unless
otherwise noted, combined with additional data derived from primary medical literature.

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vancomycin

Dosing & Uses

Interactions

Adverse Effects

Warnings

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Pharmacology

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What to Read Next on Medscape

NEWS & PERSPECTIVE

FDA OKs First Vancomycin Oral Solution for C diff Diarrhea

FDA Safety Labeling Changes: April 29, 2004

C. diff on the Rise Outside the Hospital

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