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Quercetin Plus™ (Quercetin - Bromelain Complex)

90 Veggiecaps per bottle.

Suggested retail price: 21.95 vessels, prevent easy bruising, and support the immune
Quercetin is widely distributed in the plant system—all of which are beneficial to individuals with
kingdom and has been shown in experimental diabetes.
studies to have numerous effects on the body. • Heart disease: Individuals with very low intakes of flavonoids
It is found in many often-consumed foods, are at higher risk for heart disease.
including apple, onion, tea, berries, and
• Infection: Quercetin may control the spread of certain viruses
brassica vegetables, as well as many seeds,
within the body.
nuts, flowers, barks, and leaves. It is also
found in medicinal botanicals and is often a • Aldose reductase inhibitor
major component of the medicinal activity of the plant. Quercetin • Rheumatoid arthritis: Quercetin may help reduce tissue
appears to have many beneficial effects on human health, including destruction.
cardiovascular protection, anti-cancer activity, anti-ulcer effects,
Quercetin’s anti-inflammatory activity appears to be due to its
anti-allergy activity, cataract prevention, antiviral activity, and
antioxidant and inhibitory effects on inflammation-producing
anti-inflammatory effects. Quercetin is extensively employed in
enzymes (cyclooxygenase, lipoxygenase) and the subsequent
the Protocols section of the Complete Blood Type Encyclopedia.
inhibition of inflammatory mediators, including leukotrienes
Product History and prostaglandins. Inhibition of histamine release by mast cells
This product was introduced by NAP in 2002 after first being and basophils also contributes to quercetin’s anti-inflammatory
specifically designed for use in my clinic. activity.
Quercetin’s mast-cell-stabilizing effects make it a clear choice
Description/Background
for use in preventing histamine release in allergy cases.
Quercetin is widely distributed in the plant kingdom and is the Quercetin’s cardiovascular effects center on its antioxidant and
most abundant of the flavonoid molecules. It is found in many anti-inflammatory activity. In one study, the risk of heart disease
often consumed foods, including apple, onion, tea, berries, and mortality decreased significantly as flavonoid intake increased.
brassica vegetables, as well as many seeds, nuts, flowers, barks, Interestingly, the flavonoid-containing foods most commonly
and leaves. eaten in this study contain a high amount of quercetin (tea, onions,
It is also found in medicinal botanicals and is often a major apples). Quercetin is indicated in any inflammatory condition,
component of the medicinal activity of the plant, and has been as it inhibits the formation of the inflammatory mediators
shown in experimental studies to have numerous effects on the prostaglandins and leukotrienes, as well as histamine release.
body. Quercetin appears to have many beneficial effects on human Animal studies have shown quercetin to be protective of gastric
health, including cardiovascular protection, anti-cancer activity, ulceration and an interesting aspect of quercetin’s anti-ulcer effect
anti-ulcer effects, anti-allergy activity, cataract prevention, is that it has been shown to inhibit growth of Helicobacter pylori
antiviral activity, and anti-inflammatory effects. in a dose-dependent manner.
Actions and Indications Quercetin may help treat or even prevent prostate cancer by
• Allergies, asthma, and hives: Quercetin may inhibit histamine blocking male hormones that encourage the growth of prostate
release from basophils (a type of white blood cell) and mast cancer cells, according to preliminary laboratory research at the
cells (large cells in connective tissue). Mayo Clinic. In another study, men with an inflamed prostate
(prostatitis) reported reduced urinary symptoms when they took
• Cancer: Quercetin may be beneficial in the treatment of skin quercetin. Quercetin has been investigated in a number of animal
cancer, and may have anti-tumor effects in other cancers, models and human cancer cell lines, and has been found to have
such as ovarian cancer. antiproliferative effects. It may also increase the effectiveness of
• Canker sores: Quercetin may reduce the frequency of mouth chemotherapeutic agents. More clinically-oriented research needs
sores and produce mild symptomatic relief. to be done in this area to discover effective dosage ranges and
• Diabetes mellitus: Quercetin may help prevent cataracts, protocols.
retinal disorders, nerve diseases, and other complications Quercetin’s aldose reductase-inhibiting properties may make it a
of diabetes. Flavonoids, including quercetin, also promote useful addition to diabetic nutritional supplementation, to prevent
insulin secretion, increase vitamin C levels, protect blood cataract and neurovascular complications.
Synergistic Products 19. Caltagirone S, Raneletti FO, Rinelli A, et al. Interaction with type II estrogen
binding sites and antiproliferative activity of tamoxifen and quercetin in
• Rekon Pro, Helix Plus (Malignancies) human non-small-cell lung cancer. Am J Resp Cell Mol Biol 1997;17:51-59.
• Glycoscia (diabetic management) 20. Hertog MG, Feskens EJ, Hollman PC, et al. Dietary antioxidant flavonoids
and risk of coronary heart disease: the Zutphen Elderly Study. Lancet
Dosage 1993;342:1007-1011. Pace-Asciak CR, Hahn S, Diamandis EP, et al. The
An oral dose of 300-600 mg two times per day is typically used in red wine phenolics trans-resveratrol and quercetin block human platelet
aggregation and eicosanoid synthesis: implications for protection against
clinical practice. coronary heart disease. Clin Chim Acta 1995;235:207-219
References 21. Alarcón de la Lastra C, Martín MJ, Motilva V. Antiulcer and gastroprotective
1. 1. Stavric B. Quercetin in our diet: from potent mutagen to probable effects of quercetin: a gross and histologic study. Pharmacology 1994;48:56-
anticarcinogen. Clin Biochem 1994;27:245-248. 62.
2. Kim HP, Mani I, Ziboh VA. Effects of naturally-occurring flavonoids and
biflavonoids on epidermal cyclooxygenase from guinea pigs. Prostaglandins
Leukot Essent Fatty Acids 1998;58:17-24. Model: NP031
3. Chang WS, Lee YJ, Lu FJ, Chiang HC. Inhibitory effects of flavonoids on * Manufactured by: Genoma Nutritionals
xanthine oxidase. Anticancer Res 1993;13:2165-2170.
4. Kaul TN, Middleton E Jr, Ogra PL. Antiviral effect of flavonoids on human
viruses. J Med Virol 1985;15: 71-79.
5. DeWhalley CV, Rankin JF, Rankin SM, et al. Flavonoids inhibit the oxidative
modification of low density lipoproteins. Biochem Pharmacol 1990;39:1743-
1749.
6. Chen YT, Zheng RL, Jia ZJ, Ju Y. Flavonoids as superoxide scavengers and
antioxidants. Free Radic Biol Med 1990;9:19-21.
7. Skaper SD, Fabris M, Ferrari V, et al. Quercetin protects cutaneous
tissueassociated cell types including sensory neurons from oxidative stress
induced by glutathione depletion: cooperative effects of ascorbic acid. Free
Radic Biol Med 1997;22:669-678
8. Ragazzi E, Tubaro A, et al. Anti-inflammatory activity of benzopyrones
that are inhibitors of cyclo- and lipo-oxygenase. Pharmacol Res Commun
1988;20:S91-S94.
9. Hertog MGL, Hollman PCH. potential health effects of the dietary flavonol
quercetin. Eur J Clin Nutr 1996;50:63-71.
10. Bronner C, Landry Y. Kinetics of the inhibitory effect of flavonoids on
histamine secretion from mast cells. Agents Actions 1985;16:147-151.
11. Chaudry PS, Cabera J, Juliani HR, Varma SD. Inhibition of human lens
aldose reductase by flavonoids, sulindac, and indomethacin. Biochem
Pharmacol 1983;32:1995-1998.
12. Yoshida M, Sakai T, Hosokawa N, et al. The effect of quercetin on cell
cycle progression and growth of human gastric cancer cells. FEBS Letters
1990;260:10-13.
13. Scambia G, Raneletti FO, Panici PB, et al. Quercetin induces type-II
estrogenbinding sites in estrogen-receptor-negative (MDA-MB231) and
estrogenreceptor-positive (MCF-7) human breast-cancer cell lines. Int J
Cancer 1993;54:462-466.
14. Scambia G, Raneletti FO, Panici PB, et al. Quercetin inhibits the growth
of a multidrug-resistant estrogen-receptor-negative MCF-7 human breast-
cancer cell line expressing type II estrogen-binding sites. Cancer Chemother
Pharmacol1991;28:255-258.
15. Castillo MH, Perkins E, Campbell JH. The effects of the bioflavonoid
quercetin on squamous cell carcinoma of head and neck origin. Am J Surg
1989;158:351-355.
16. Singhal RL, Yeh YA, Prajda N, et al. Quercetin down-regulates signal
transduction in human breast carcinoma cells. Biochem Biophys Res Comm
1995;208:425-431.
17. Gugler R, Leschik M, Dengler HJ. Disposition of quercetin in man after
single oral and intravenous doses. Eur J Clin Pharmacol 1975;9:229-234.
18. Scambia G, Raneletti FO, Panici PB, et al. Synergistic antiproliferative
activity of quercetin and cisplatin on ovarian cancer cell growth. Anticancer
Drugs 1990;1:45-48. Mizui T, Sato H, Hirose F, Doteuchi M. Effect of
antiperoxidative drugs on gastric damage induced by ethanol in rats. Life
Sci 1987;41:755-763.

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