1 - TB
1 - TB
1 - TB
tuberculosis and is spread from person to person via airborne droplets (e.g. when an infected
person coughs or sneezes). Tuberculosis primarily affects the lungs (causing pulmonary
tuberculosis), but it can also affect other organs, e.g. central nervous system, lymphatic system,
person first becomes infected, the tuberculosis bacteria generally lay dormant in the body and
the person will not manifest any symptoms, this is termed “Latent Tuberculosis Infection”.
Persons with Latent Tuberculosis Infection are not infectious. However, in about 10% of
healthy individuals with Latent Tuberculosis Infection, active tuberculosis disease may
eventually develop over their lifetime. The highest risk of progressing to active tuberculosis
disease is in the first two years after initial infection. In persons who are immunocompromised
(e.g. the elderly or those who are human immunodeficiency virus (HIV) positive), the rate of
progressing to active tuberculosis disease will be higher than in healthy individuals. For
example, individuals with untreated HIV co-infection may progress from Latent Tuberculosis
Infection to active tuberculosis disease at the rate of 5-8% per year, with a lifetime risk of
approximately 30%.
2|Page
CAUSES:
through the air when a person with TB (whose lungs are affected) coughs, sneezes, spits,
laughs, or talks. When these bacteria enter the lungs, they are usually walled off into harmless
capsules (granulomas) in the lung, causing infection but not disease. These capsules may later
People with well-functioning immune systems may not experience TB symptoms, even
though they are infected with the bacteria. This is known as latent or inactive TB infection.
According to WHO, about one-quarter of the world’s population has latent TB. Latent TB isn’t
contagious, but it can become an active disease over time. Active TB disease can make you and
others sick.
PROGRESSION OF TUBERCULOSIS
3|Page
SYMPTOMS:
Symptoms are usually mild and tend to present over a period of weeks, months, or
sometimes years. TB disease symptoms are often initially mistaken for a smoker’s cough,
allergies, or chronic bronchitis from a lingering cold or flu infection. TB infection most often
affects the lungs but can cause problems in other parts of the body. The latent TB is
Low-grade fever
Night sweats
Tuberculosis usually affects the lungs, but can also affect other parts of the body. When
TB occurs outside of the lungs, the symptoms vary accordingly. Without treatment, TB can
TB infecting the bones can lead to spinal pain and joint destruction
TB infecting the liver and kidneys can impair their waste filtration functions and lead to blood
in the urine
TB infecting the heart can impair the heart's ability to pump blood, resulting in a condition
DIAGNOSIS:
screening test, either a tuberculin skin test (TST) or a blood test called an interferon gamma
release assay (IGRA). The TB skin test is also called a Mantoux test or a PPD skin test because
the material used in the skin test is called purified protein derivative (PPD). These tests detect
positive result indicates that a person has been infected with the tuberculosis bacteria at some
point in his or her life. TB disease is suspected clinically when a person presents with the
symptoms mentioned above usually together with abnormal findings on a chest x-ray. If TB
disease is suspected, the person should be isolated from the public until the diagnosis is made
separate samples of sputum (phlegm) often collected on different days. The sputum is first
looked at under a microscope using a special dye (acid fast bacillus AFB stain) to see if any
tuberculosis bacteria can be found. It is not always positive as there may be only a small
number of bacteria so a culture is always needed. Sputum cultures are done to grow the
bacteria to confirm the diagnosis and determine the best combination of drugs for treatment.
sputum. In addition to these tests, chest X-ray and CT chest imaging are performed to evaluate
for any lung abnormalities. If TB is suspected in a different part of the body, a different sample
or a tissue biopsy may be needed. MDR-TB is more difficult to diagnose than regular TB. It is
AT RISK OF TUBERCULOSIS:
According to WHO, more than 95% of all deaths related to TB cases occur in low and
middle-income countries. People who use tobacco or misuse drugs or alcohol long term are
more likely to get active TB, as are people diagnosed with HIV and other immune system issues.
TB is the leading killer of people who are HIV-positive, according to WHO. Other risk factors
diabetes
malnourishment
certain cancers
Medications that suppress the immune system can also put people at risk for developing active
TB disease, in particular medications that help prevent organ transplant rejection. Other
medications that increase your risk of getting TB include those taken to treat:
cancer
rheumatoid arthritis
Crohn’s disease
psoriasis
lupus
Traveling to regions where TB rates are high also increases your risk of contracting the
sub-Saharan Africa
India
TREATMENT:
Many bacterial infections are treated with antibiotics for a week or two, but TB is
different. People diagnosed with active TB disease generally have to take a combination of
medications for six to nine months. The full treatment course must be completed. Otherwise,
it’s highly likely a TB infection could come back. If TB does recur, it may be resistant to
Treatment of latent TB infection consists of 1 or 2 oral medications that kill the bacteria and
greatly reduces the risk of the infection progressing to TB disease immediately and later in life.
There are several treatment options that include isoniazid taken daily for six to nine months,
rifampin taken daily for 3 to 4 months or isoniazid plus rifapentine taken once weekly for 12
weeks. These medications can affect your liver, so people taking TB medications should be
appetite loss
dark urine
abdominal pain
. TB disease is usually treated with 4 anti-TB medications for at least six months. If TB is
in the bones, brain or other hard-to-reach areas, treatment will be longer. This can mean
taking 6-12 pills per day! Many patients find this difficult without the support of workers
trained in providing directly observed treatment (DOT). DOT is the universal standard for
treating TB worldwide. DOT helps detect side effects early and prevents missed doses and
breaks in treatment that reduces the benefit of treatment and can lead to drug-resistant strains
of bacteria.
7|Page
PREVENTION:
food, utensils, and drinks, touching, or having sex. Covering the mouth and nose when
coughing is an important way to stop the spread of TB and other airborne diseases. If you have
TB disease and are coughing, it is important to wear a mask and limit contact with others until
your health care provider tells you that you are no longer contagious while on treatment.
Seeking care right away and finding out you have TB is the best way to stop its spread since
TB vaccination
In some countries, BCG injections are given to children to vaccinate them against tuberculosis.
It is not recommended for general use in the U.S. because it is not effective in adults, and it can
The most important thing to do is to finish entire courses of medication when they are
prescribed. MDR-TB bacteria are far deadlier than regular TB bacteria. Some cases of MDR-TB
require extensive courses of chemotherapy, which can be expensive and cause severe adverse
IP no. : I 18014249
OP no. : O 18029049
1. PATIENT PROFILE
b. Age : 73 years
c. Community : Muslims
d. Gender : Male
e. Occupation : Nil
2. USE OF APPROPRIATE SCREENING TOOL AS PER THE INSTITUTION: (SGA, NRS, STAMP,
etc.)
Weight 34Kg
Height 167cms
BMI 12.19Kg/m2
MCH 28.0 pg 27 – 32 pg
Eosinophil % 0.0 % 1 - 6%
Basophil % 0.1 % 0 - 2%
ESR (1HR) 22 mm 3 – 10 mm
10 | P a g e
Urea (serum)
Proteins (serum)
Electrolytes
FiO2 29.00 % -
pCO2 52.2 mm Hg 35 – 45 mm Hg
Temperature 37.00C -
Proteins (serum)
Electrolytes
FiO2 29.00 % -
PROTHROMBIN TIME
INR 1.55
VITALS:
10/5/18 100 110 102 100 98 - 22 22 22 22 22 - 110/60 100/60 2000 1300 98.4o
11/5/18 100 120 108 100 110 - 22 22 22 22 22 - 100/60 100/70 2350 1600 98.4o
12/5/18 98 120 108 100 102 - 22 22 22 22 22 - 100/60 100/60 1775 1200 98.4o
13/5/18 110 100 116 102 84 - 20 20 20 20 20 - 100/60 120/70 1925 1650 98.4o
DIABETIC MONITORING
9/5/18
CLINICAL DATA
Breathlessness x 15 days
Cough x 3 years
Adjustment disorder
ENDOSCOPIC DIAGNOSIS:
USG ABDOMEN
Impression:
NOTES:
8/5/18
LV - 35/22
EF - 66%
9/5/18
10/5/18
Bed wetting
C/O sleeplessness
12/5/18
Poor intake
13/5/18
Better intake
14/5/18
On home oxygen
Medication / Treatment
Syp. Alex 10ml It is a cough suppressant that relieves cough by reducing the activity
Syp. Mucaline Gel 10ml It is used in the treatment of acidity, heartburn and stomach ulcers.
the lung. This relaxes and opens up the air passages to make breathing
easier.
T. Pan 40mg It is a proton pump inhibitor (PPI). It works by reducing the amount of
and heartburn.
causes tuberculosis.
tuberculosis.
T. Renerve plus It is used for Nerve damage, Pain in neurological disorders, Numbness
conditions.
Threptin Diskettes They are high-calorie protein supplements helpful for the growth of
body. Patients who have a lack of essential protein in their body due to
faulty diets or illness take this biscuit. It can be easily digested and can
known to supply enough calories to the body which is essential for the
DIET HISTORY
24-hour recall + empty calories intake from food frequency table (as given below)
Sugar 20g - 80 - 20 -
TOTAL EMPTY
FOOD ITEMS DAILY WEEKLY FORTNIGHT MONTHLY
CALORIE
Pickle
Papad
Chats
Fast foods
Carbonated Beverages
Bakery foods
Fried foods
Sweets
Other relevant disease specific nutrients (Ca, Fe, Na, K, Fibre, etc.,)
21 | P a g e
NUTRITIONAL INTERVENTION
DIET ORDER:
Meals should be provided at frequent intervals to increase the amount of food intake
To manage the symptoms of the TB drugs such as anorexia, diarrhea and altered taste
22 | P a g e
INTERVENTION:
SODIUM : 2400 mg
POTASSIUM : 4700 mg
Sugar 20g - 80 - 20 -
Sugar 20g - 80 - 20 -
Sugar 20g - 80 - 20 -
Sugar 20g - 80 - 20 -
Sugar 20g - 80 - 20 -
Sugar 20g - 80 - 20 -
Sugar 20g - 80 - 20 -
Sugar 20g - 80 - 20 -
HOSPITAL RECALL
DISCHARGE DIET:
6. SODIUM : 2400mg
7. POTASSIUM : 4700mg
8. NNC/NPC : 1528Kcal
Vitamin B : 2.4g/day
Zinc : 11 mg/day
Vitamin D : 20g/day
Vitamin E : 15 mg/day
Selenium : 55g/day
32 | P a g e
pulses 2 170 12 30 -
oil 2 180 - - 20
egg white 5 75 20 - -
veg A 1 30 - 6 -
veg B 1 55 3 10 -
sugar 20g 80 - 20 -
MEAL DISTRIBUTION
cereals 9 3 3 3
pulses 2 1 ½ ½
egg white 5 1 3 1
veg A 1 1
veg B 1 ½ ½
SAMPLE MENU:
EM milk 100ml 1 65 3 4 4
BT milk 100ml 1 65 3 4 4
Sugar 20g - 80 - 20 -
Anthropometry:
There was no change in the weight of the patient. The patient seemed to be
Biochemical parameters:
The ESR rate seemed to be high at the time of admission. The liver function tests also
showed abnormal ranges in its normal values. The sodium level was low at the time of
The patient seemed to be very weak at the time of admission and his health was
Diet compliance:
The patient’s intake was very low at the time of admission and his intake was slowly
improved. The patient was then shifted to high protein diet and his intake slowly improved.
SUMMARY:
The patient was a 73 year old with complaints of cough, breathlessness and difficulty in
swallowing for about 15 days. He was diagnosed with pulmonary tuberculosis (on modified
ATT since 10/5/18), chronic obstructive pulmonary disorder (COPD), Moderate pulmonary
arterial hypertension (PAH), Type II Respiratory Failure (On Home Oxygen), Adjustment
disorder, possible chronic liver disease. He seemed to be very malnourished and weak. His
intake was also poor at the time of admission and slowly improved well, but didn’t meet his
daily needs.
35 | P a g e
DIETARY INTAKE
1. No Change; Adequate
2. Inadequate; Duration Of Inadequate Intake Soft diet
Suboptimal Solid Diet Full Fluids or Oral Nutrition Supplements Minimal-Intake, Clear Fluids or Starvation
3. Dietary Intake In Past 2 Weeks
Adequate 1500Kcal Improved but not adequate ________ No Improvement or Inadequate
WEIGHT Usual weight 62 kg Current weight 44 kg Height 167 cms
1. Non fluid weight change in past 6 months Weight loss (Kg) 10Kg
<5% loss or weight stability 5-10% loss without stabilization or increase >10% loss and ongoing
If above not known, has there been a subjective loss of weight during the past 6 months?
None or Mild Moderate Severe
2. Weight change In the past 2 weeks Amount (if known) 5Kg
Increased No Change Decreased
SYMPTOMS (Experiencing symptoms affecting oral intake)
1. Pain on eating Anorexia Vomiting Nausea Dysphagia Diarrhea
Dental problems Feels full quickly Constipation Decreased intake & appetite
2. None Intermittent/mild/few Constant/severe/multiple
3. Symptoms in the past 2 weeks
Resolution of symptoms Improving No change or worsened
FUNCTIONAL CAPACITY (Fatigue & Progressive loss of function)
1. No dysfunction
2. Reduced capacity, duration of change _____________
Difficulty with ambulation / Normal activitiesBed / Chair-ridden
3. Functional capacity in the past 2 weeks
Improved No change Decreased
METABOLIC REQUIREMENT
High metabolic requirement No Yes
PHYSICAL EXAMINATION
Loss of body fat No Mild/Moderate Severe
Loss of muscle mass No Mild/Moderate Severe
Presence of edema/ascites No Mild/Moderate Severe
CACHEXIA
No Yes
SGA RATING
A – Well-nourished B – Mildly/ Moderately malnourished C- Severely malnourished
Normal Some progressive nutritional loss Evidence of wasting & Progressive symptoms
A – Detailed assessment not required (follow up after 3 days/ at the time of Discharge
B – To continue detailed assessment (review once in 2 days)
C – To continue detailed assessment (review everyday)
36 | P a g e
2. Problem :
Etiology:
Signs & Symptoms:
3. Problem :
Etiology:
Signs & Symptoms:
NUTRITION INTERVENTION:
Nutrition prescription: