Location via proxy:   [ UP ]  
[Report a bug]   [Manage cookies]                
Scribd Logo
Upload

Welcome to Scribd!

  • 50 views

    2.3 Sulfated Ash: The International Pharmacopoeia - Ninth Edition, 2019

    Uploaded by

    JAHIDUL ISLAM
    The document describes test methods for determining sulfated ash content. Method A involves accurately weighing a sample, moistening it with sulfuric acid and igniting it at high temperatures until the particles disappear. Method B also involves igniting a crucible, weighing the sample within it, moistening the sample with sulfuric acid and gently heating it at low temperatures until white fumes are no longer emitted, then igniting at high temperatures until completely incinerated. The percentage of residue obtained is calculated, and the process may be repeated if the amount of residue exceeds specified limits.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    2.3 Sulfated Ash: The International Pharmacopoeia - Ninth Edition, 2019

    Uploaded by

    JAHIDUL ISLAM
    50 views1 page
    The document describes test methods for determining sulfated ash content. Method A involves accurately weighing a sample, moistening it with sulfuric acid and igniting it at high temperatures until the particles disappear. Method B also involves igniting a crucible, weighing the sample within it, moistening the sample with sulfuric acid and gently heating it at low temperatures until white fumes are no longer emitted, then igniting at high temperatures until completely incinerated. The percentage of residue obtained is calculated, and the process may be repeated if the amount of residue exceeds specified limits.

    Original Description:

    Sulfated ash of lube oil

    Original Title

    7.2.3.2.3-Sulfated-ash

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    The document describes test methods for determining sulfated ash content. Method A involves accurately weighing a sample, moistening it with sulfuric acid and igniting it at high temperatures until the particles disappear. Method B also involves igniting a crucible, weighing the sample within it, moistening the sample with sulfuric acid and gently heating it at low temperatures until white fumes are no longer emitted, then igniting at high temperatures until completely incinerated. The percentage of residue obtained is calculated, and the process may be repeated if the amount of residue exceeds specified limits.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    50 views1 page

    2.3 Sulfated Ash: The International Pharmacopoeia - Ninth Edition, 2019

    Uploaded by

    JAHIDUL ISLAM
    The document describes test methods for determining sulfated ash content. Method A involves accurately weighing a sample, moistening it with sulfuric acid and igniting it at high temperatures until the particles disappear. Method B also involves igniting a crucible, weighing the sample within it, moistening the sample with sulfuric acid and gently heating it at low temperatures until white fumes are no longer emitted, then igniting at high temperatures until completely incinerated. The percentage of residue obtained is calculated, and the process may be repeated if the amount of residue exceeds specified limits.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    You are on page 1of 1

    The International Pharmacopoeia - Ninth Edition, 2019 2.

    3 Sulfated ash

    2.3 Sulfated ash


    The test Method B is based on the internationally-harmonized texts developed by the Pharmacopoeial Discussion Group (PDG).
    Some editorial modifications have been made in order to be in line with the style used in The International Pharmacopoeia.

    The sulfated ash test uses a procedure to measure the amount of residual substance not volatilized from a sample when the
    sample is ignited in the presence of sulfuric acid. The test is usually used for determining the content of inorganic impurities in an
    organic substance. Unless otherwise indicated in the individual monograph, use Method A.

    Method A

    Accurately weigh about 1 g of the substance, or the quantity specified in the monograph, into a suitable crucible (usually
    platinum) and moisten with sulfuric acid (~1760 g/l) TS. Heat gently to remove the excess of acid and ignite at about 800 °C until
    all the black particles have disappeared; again moisten with sulfuric acid (~1760 g/l) TS and reignite. Add a small amount of
    ammonium carbonate R and ignite to constant weight.

    Method B

    Ignite a suitable crucible (for example silica, platinum, quartz or porcelain) at 550 °C to 650 °C for 30 minutes, cool the crucible in
    a desiccator (silica gel or other suitable desiccant) and weigh it accurately. Take the amount of test sample specified in the
    individual monograph in the crucible and weigh the crucible accurately. Moisten the sample with a small amount (usually 1 mL) of
    sulfuric acid (~1760 g/l) TS, heat gently at a temperature as low as practicable until the sample is thoroughly charred. After
    cooling moisten the residue with a small amount (usually 1 mL) of sulfuric acid (~1760 g/l) TS, heat gently until white fumes are
    no longer evolved and ignite at 550 °C to 650 °C until the residue is completely incinerated. Ensure that flames are not produced
    at any time during the procedure. Cool the crucible in a desiccator (silica gel or other suitable desiccant), weigh accurately and
    calculate the percentage of residue.

    Unless otherwise specified, if the amount of residue so obtained exceeds the limit specified in the individual monograph, repeat
    the moistening with sulfuric acid, heating and ignition as before, using a 30-minute ignition period, until two consecutive
    weighings of the residue do not differ by more than 0.5 mg or until the percentage of residue complies with the limit in the
    individual monograph.

    Page 1 of 1

    You might also like