Fundamentals of Pathology. Medical Course and Step 1 Review
Fundamentals of Pathology. Medical Course and Step 1 Review
Fundamentals of Pathology. Medical Course and Step 1 Review
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Growth Adaptations, Cellular Injury, and Cell Death . . . . . . . . . . . . .1
Principles of Neoplasia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23
Vascular Pathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65
Cardiac Pathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73
Respira
espirator
oryy Tr
Trac
actt Pathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85
Gastr
astroin
ointtestinal P
Paathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99
Exocrine
Ex ocrine Pancr
Pancreas
eas,, Gallbladder
Gallbladder,, and Liver
Liver Pa
Pathol . . . . . . . . . . .115
115
Kidne
idneyy and Urinary
Urinary Trac
actt Pa
Pathology . . . . . . . . . . . . . . . . . . . . . . . . . . 125
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 213
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Growth
GrowthAdaptations,
Adaptations,Cellular
Cellular
Injury,
Injury,and CellDeath
andCell Death 11
GROWTH ADAPTATIONS
I. BASIC PRINCIPLES
A. An organ is in homeostasis with the physiologic stress placed on it.
B. An increase, decrease, or change in stress on an organ can result in growth
adaptations.
III. ATROPHY
A. A decrease in stress (e.g., decreased hormonal stimulation, disuse, or decreased
nutrients/blood supply) leads to a decrease in organ size (atrophy).
1. Occurs via a decrease in the size and number of cells
B. Decrease in cell number occurs via apoptosis.
C. Decrease in cell size occurs via ubiquitin-proteosome degradation of the
cytoskeleton and autophagy of cellular components.
1. In ubiquitin-proteosome degradation, intermediate filaments of the cytoskeleton
are "tagged" with ubiquitin and destroyed by proteosomes.
2. Autophagy of cellular components involves generation of autophagic vacuoles.
These vacuoles fuse with lysosomes whose hydrolytic enzymes breakdown
cellular components.
IV. METAPLASIA
A. A change in stress on an organ leads to a change in cell type (metaplasia).
1. Most commonly involves change of one type of surface epithelium (squamous,
columnar, or urothelial) to another
2. Metaplastic cells are better able to handle the new stress.
B. Barrett esophagus is a classic example.
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1 1
1 11 11
1 11 11
11
1 1 11 1 1 1
1
11 11 1 1
11 1
11 1 1
11 11 11 1 1 11
11 1 1 1
1 1 1
1 1 1 1
1 1 11 1
1 1
1 1 1
11 1 1
1
1 1 1
1
11 1 1
1 1 1
1 1
1 1
11 1 1 11 11 1 1 1 1
1
1 1 1 1
1 1 1 1
1 1
1
https://t.me/USMLEPathoma https://t.me/USMLEPathoma
2
1 11
1 1
1 11
1
1 1
1
1 1 1 1
1 1
1 1 1
1
1 1
1 1
1
11 11
111 1
111 1
1 1
1 1
1 1 1 1
1 1 1
1 1
1
1 1
1
1 1
1 11 1
1 1
1 11
1 1 1
1 1 1
1 1
1 1 1 1
1
1 1 11
1
1 1
11 1 1 1
1
11 1
1 1
11 1 1 1 1
1 11 1
1 1 11
1 11 11
1 1 11
1 11
1
1 1
1 1
1 1
11 11 1 1
11 11 1
1 11 1
1 11 1
11 1
1
1
11
1
1 1
1
11
1 1 11
1
11 11
1
1
1 1
1 1
https://t.me/USMLEPathoma https://t.me/USMLEPathoma
Index 2
1
11 1
1 1
1
1 1 1
1 1 1 1 1
1
1 1 1
1 1 1
1 1 1
1 111 1
1 1 1 1
1
1 1
1 11
1
1 11 1
1 1 1
1
1 1
1 1 1 1
1 11
1 1 1 1
1 1 1 1
1
1 1
1 1
1 1 1 1 1
1
1 1 1
1 1 1
11 1
1
1 1
1
1
11 1 1
1 1
1 1
1 1
1
1 1 1
1 1 1 1
1 1 1
11 1 1
1 1
1
11 1 1 1
1 1 11 11 1 1
1 1
1 1 1
1 11
neu 1 1
1 11 neu
1 1
1 1
1 1 1 11
1 111 1
11
11 1
1
1 11 1
1 1
1 1
1 1 1
1 1 1
1 1
https://t.me/USMLEPathoma https://t.me/USMLEPathoma
2
11
1 1
1 1 1
1 1
1 1 1
1 1 1 11
1 1 1
1 11 1
I 1
111
1 1 1 1
1 1 1 111 1
11
1 11
1
11
1
1
1
1
1 1 1 1
1 1
1 11 1
1 1 11
1 11 11 11 11
1 1 1 1 11
1 1 1 11
1 1
1 11 1
1
1
1
1 1 1
1
1
1
1
11 1
1
1
1
1 11
11
1 1
11 1
1
11 11
1
1
1 1
1 11 1
1
1
1
11 1
1
1 1
1 11
1 1
1
1 11
ras 11
11
1 1
1
1
1 1 1 1
1
1
1 1 1
β 1 1 1
γ γ 1 1
1
1
1
1 1 1
1 1
1 1
1
11
https://t.me/USMLEPathoma https://t.me/USMLEPathoma
Index 2
1
11
1
1 1
1
1
1 1
1
1
1 1
1
11 1
1
1
1
1 11
1
1 1 1
1
11 1
11 1 1
1 1
1 1
1 11
1
1 1 1 1 1 1 1
1 11 1
1 1 1 1
11
1 1
1
1 1
1 1
1
1 1
1
1 1 1
1 1
1
1 1
1
1 1 1 1
1 1
1
1 1 1 1 1
1 1 11 1 1
11
1 11
1 1 11
1 1 1
1 1
1 1 1
1 1
1 1 11
1 1
1 1 1 1
11 1
11 1 1 κ 11
1 1 11
1 1 1
1 1
11
https://t.me/USMLEPathoma https://t.me/USMLEPathoma
22
1 1
11 1
11 1
1 1 1 1 1
11 1 1 1
11 1
1 1 1
1 1 1 1
1 1
1 1 1 1
1 1 1 1 1
1 1
1
1
1 1
1 1 1
1 1
1
1 1 1 1
1 1 1
1 1
1 11 1
1 1
1
1 1 1 1
1 1 1
1
1
1 1 1 1
1
1 1 11
1 1
1
1 11 1
1 1
1 1 1
1 11 1
1 11
1 1 1
1 1
1 1
1 1
1 11
1
1 1 1 1
1 1
1 1
1
1 1 1 1
1 1 1
11 11
1 1 1 1 1
1 1
1
1 1 ,1 11
1 1 1 1
1 1
1 1 1
1 1 1
1 1 1
1
1 1 1
11 11
1 1
11 , 11
1 ,
https://t.me/USMLEPathoma https://t.me/USMLEPathoma
Index 22
1 1 1
1 1 1
1
1
1 1 1 11
1 1 11
RET 1 1
1 1
11 1
1 11
1 1 1 1
11 1 11
11 1 1
1 1
1
1 1 1
1 1 1 1
1 1 1
1
1 1 1
1
1
1 1 1
1 1
1 1 1
11
1 1 1
1 1
1
1 1
1 11
1 11 11 1
1 1
11 1
1
Salmonella paratyphi
Salmonella typhi 1
1
1 1 1 1
1
1
1 1
1 11
11
1
1 1 1 1 1
1 1
as
1 1 1
1 1 1
1 11
1
1
1
1 1
1
1
1
1 1
1 1
1
1
1 1 1
1 1 11
1 1
1 1 1
1 1
1
1 11
1
1 Staphylococcus aureus, 1 1 1 1
1
1 1 11
1
https://t.me/USMLEPathoma https://t.me/USMLEPathoma
222
1
11 1 1
11 11 1 1
1 11 1
1 11
1 1 1 1 11
1 1
α 1
β β 1
β 1 1
1 1
1
1 1 1
11 1 1
1 1 1 11 1
1
1 1 1
1
1 1 1
1 1
1 1
1 1 1 1 1
1 1 1 1 1
1 1 11
1 1 1 11
1 1
1 1
β β 1 1
1 1 11
11 1
1 1 1 1 1
+ 1 1
+ 1 1
1 1 11
1 1 1
1 1 1
1 1 1
1 1
1 1
1 1
1 1
1 1
1
1 1
1
1
11
11 1 1 1
1
1
11 1 1
1 1
1
1 1 1
1 1
1
1
1
1 1
1 1
1
1
1
1
1
11
1
1
1
1
1
1 1 1
1
1
https://t.me/USMLEPathoma https://t.me/USMLEPathoma
Index 223
1
1
1 1
1
1
1
1
1 1
1
1
11
1
1 1
1
1
1
1
1
1 1
1
1
11
1
1
1 1
11
https://t.me/USMLEPathoma https://t.me/USMLEPathoma
https://t.me/USMLEPathoma https://t.me/USMLEPathoma
https://t.me/USMLEPathoma https://t.me/USMLEPathoma
https://t.me/USMLEPathoma https://t.me/USMLEPathoma