Buccal Drug Delivery System
Buccal Drug Delivery System
Buccal Drug Delivery System
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Introduction :
Introduction Transmucosal routes as an alternative method of systemic drug delivery over the
injectables and enterable methods which includes Noninvasive administration, Rapid onset of action,
Good bioavailability, Elimination of hepatic first pass metabolism
Buccal Cavity :
Buccal Cavity The Buccal mucosa lines the inner cheek Placed between the upper gingival and cheek
Merits :
Merits Bypass the hepatic first pass effect Immobile surface area Abundant vascularisation, Rapid
recovery time Self-administrable Painless administration Easy drug withdrawal
Demerits :
Demerits Drugs having unpleasant taste or odor, instability at buccal pH, irritability to buccal mucosa
cannot be administered by this route. Drugs that are not absorbed by passive diffusion. Swallowing of
saliva can lead to the loss of drug
Contd… :
Contd…
Absorption pathways :
Absorption pathways
Buccal formulations(solid) :
Buccal formulations(solid)
Buccal formulations(semisolid) :
Buccal formulations(semisolid)
Experimental Methodology :
Experimental Methodology Evaluation
Slide 19:
Experimental animal species for invivo-studies
Slide 20:
Research on mucoadhesive polymers And delivery systems
Conclusion :
Conclusion
Slide 23:
THAN Q