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Kinetics of Multiple Dosing

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Blophamacwuhcs Phomocoknekica BP604T

Unil-y

KinaticsMukbb DoAin9 Dr. Parjanya Shukla


&
Dr. M. P. 5Stngh Classe

i oage Regimns-
dingd Ki in which
X
DoA
DoAa9e Ragiman as
drug is taken
mannir a

* Tor dom drugs bk - analgesics, byþnokics, anhemahcs e

aa Aingl doA may provids elfachva tuabmunk.

toY Bomu ilnuMAs» drug ars uquired to bs taken on

a epihva basis Or o period Hm

So Jov succnlu Kraby , design o an ophimum


mulhbl dosog Jug imen in nu cuma

xAn 0phmum Mulipl dosage Ragiman is Ki on

in which drug s odminiaBarad in uitablu doxs


(by 0 uwiBablo xoule)wi bulliuknteqn hat thar
QhAurAs maintenanu plasma con&nraion oim in
Irabaukc toindouo or enkira dunahon of Karaby

Apbroachto Duaign d DoaRegimen


(0)Empivical Do»age Rigiman
4 i dosignud by H phyaicion barad on

empinical clinical daba, þarxonal expevienu and clinical


obsvations
(Tkis apbToach is nof vany accrata)
()Thdividualigad Doxag Rogiman - Dr. Parjanga Shuhla
&
i s monl occwnal approoch basad on Dr. M. P. ingh Clasaea

hamatokinhes odrug in the individual patent

xTh's abprooch is buitabl fov hospihalisad pokonts


bud quls Rxpenaive
)Doagq Kagimen on Populakon Avaragos
Mast ofan sad approo ch

basad on on o h two modals.

a) fixod Modal
Hara bopuwakon averoq phomacokinuhic þaromatava
ad dirtkl to caludal dos 094 sagiman.

Cb) Adophva Modid:


X basud bastd on bot

bopwahon,
avArag phomacokinhic paromatsrs and
bakont Voriak JLs Auh as wight, gge , ARX
body Auuau 0rAa and known paHent
pakophyxiolog Auch as xunal danasa

Os ao Ths mag nituds o b o


L
Ropwic and toxic suspomsas dapends ubon doae aiza.
h cadcuahon uquiTA Knowlidgs o amount of drug abaoTbed oqtar
odminiaohon each do.
xGrialar H dosaqe ie q7alr h lwchuahions
btCss,max and Css, min Dr. Parjanya Shukla
duing 2ach intarva doing Dr. M.P. Singh Classes

9Tatar h chonus d toxiaity

T
Lorgs doss þrofilu
0rimum lutuahon
shouo boh Kerahuht
and toxic xesponsa.
msc
ophrum donsprolks
herabuheall
sucusful
MEC
Smallur doaL prufilu
min- utuahion
but tnauliulznt
henabeukrally

Doaing. fraguny
XTh dos intarval i calulated on th basis of

half-fa d K dug
X hs intarva intriased and doAe s unchan gtd

max, min Cav dYRasAs


and

but Cmax/ Cmin increas s

opbosit is obanvsd whn dos/ng ntavval ib uduad


oT doing auancu hcreas ad
A propiY balona b/w both doss Ai3 and
Dr. Parjanya Shukla
dosing d7 gunty s desirable &
Dr. M.P. 3tngh Clases
to atlain otsody staki comunhalHon wih minimum uchuaton
and fo onsuT Kerafbeuhic efficay and dofky

High dosing fngunuy


tti)
ln fluchuahan ku
shows boh therapuhic
and toxit uspomses.
MsC
Obhimum doning
agueny (T ta)
Knopubtally
suluful
MEC
Les doning figunu
(T> tiy)
Lorgucbuahons
Arabuhraly
mL unAuCul
By-Dr. mahendro PraBab Sin g |

Drug Accwmulakon Duning Mulkplh Doaing

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