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    Evaluation or Testing of Pharmaceutical Aerosols

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    balavkp008
    (1) The document outlines various tests and evaluations performed on an industrial foam aerosol product, including tests for flammability and combustibility, physicochemical characteristics, performance, particle size determination, and biological characteristics. (2) Key tests include determining the flash point, vapor pressure, density, moisture content, aerosol valve discharge rate, spray pattern, dosage with metered valves, net contents, foam stability, and particle size. (3) Biological tests evaluate the therapeutic efficacy and toxicity of the product through inhalation and topical applications on test animals.

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    © All Rights Reserved
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    Evaluation or Testing of Pharmaceutical Aerosols

    Uploaded by

    balavkp008
    752 views4 pages
    (1) The document outlines various tests and evaluations performed on an industrial foam aerosol product, including tests for flammability and combustibility, physicochemical characteristics, performance, particle size determination, and biological characteristics. (2) Key tests include determining the flash point, vapor pressure, density, moisture content, aerosol valve discharge rate, spray pattern, dosage with metered valves, net contents, foam stability, and particle size. (3) Biological tests evaluate the therapeutic efficacy and toxicity of the product through inhalation and topical applications on test animals.

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    (1) The document outlines various tests and evaluations performed on an industrial foam aerosol product, including tests for flammability and combustibility, physicochemical characteristics, performance, particle size determination, and biological characteristics. (2) Key tests include determining the flash point, vapor pressure, density, moisture content, aerosol valve discharge rate, spray pattern, dosage with metered valves, net contents, foam stability, and particle size. (3) Biological tests evaluate the therapeutic efficacy and toxicity of the product through inhalation and topical applications on test animals.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    752 views4 pages

    Evaluation or Testing of Pharmaceutical Aerosols

    Uploaded by

    balavkp008
    (1) The document outlines various tests and evaluations performed on an industrial foam aerosol product, including tests for flammability and combustibility, physicochemical characteristics, performance, particle size determination, and biological characteristics. (2) Key tests include determining the flash point, vapor pressure, density, moisture content, aerosol valve discharge rate, spray pattern, dosage with metered valves, net contents, foam stability, and particle size. (3) Biological tests evaluate the therapeutic efficacy and toxicity of the product through inhalation and topical applications on test animals.

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    Tndusrial Phomay 1 Uni5

    BP502T

    Evaluaion 0ashing Aronols


    Dr. Parjanaya Shukla

    Dr.M.9.3ingh Cloms
    ) lammoabilhy and Combushbiihy
    0 flash oint
    ) fJamu axtension
    () Physicochumical charactarishs.
    (1) Vabaur pranur
    (ii) Densiky
    Ciii) Moisturs contant
    v) Idenhficahon of opallant )
    Conuntrals - propallanB Mdio.

    Performanu. xate.
    ci Agroao valv1 dischorga
    Ui Spray pattern
    ii) Doaaga toith maevad valvas
    (IV) Net contents
    (Vtoam stabilbhy
    v) Poriclu Siza detarminabom
    n) akage
    bioJogita CharacterisHics.

    fJamfJam Exbension Tk pToduct is sprayed oT


    abo 4 AC oto o
    lama.
    Depanding on K naurA o Ki foamulahn K
    lom xtendid

    h Qxact Jangh is muasured wih Atalu

    flash Poiok Dne by SBandavd Tag Ohan Gs Aphanaus


    Th aTOAOJ oduet is chillud to -2s°f tronmld
    +R test apparatus
    HemperadurA ImTeasd slowly and K tamparakurs a
    which vabaur ianita is taken as flash þoint.
    )VabouT r s A - Thu prwUrL con bs mas.ured
    simply wilh o brmuTA gauge or Dr. Parjanga Shuhla
    spacial 0quipment Dr. M. P. Stngh Classe

    Ai impoton
    4i Ra th promara vOriabon pom
    containg7s
    bs detay mintd excenive vaviahon indicates prsanca
    ouy in Kiadspau

    4)Denaih_-Thu dasiby an amosol may b


    syshem
    datermined Krough a hydromater 0r a pycnomekar

    6) MoisturA-Kar nlko
    tiahevban
    mathod
    wid.
    on Gas chomabograbh
    has also ben wsed

    6) Idemicabon 'robellants
    Cas chromatograbhy and 0.
    inrared spackrophotom.ehy Kave
    been ad toidenhfy ropallans and i
    TopOY Hon

    Aarozol Valve Diachorge Rata


    This i daBorminud by tabing on arOka psoduch o
    known Wight and diachavging9 tKi contens 0
    0 givgn imL

    A Wighs d otngiven Hm

    Chong in wight PeT Hmis it dischavqe suate.


    xepd I 9 o m Stcond,

    (3) Dozaq2 i h Meteied V'alvas

    AcaTaally wughed lhd Containe and dispans


    Srveral dosage
    Th COntaineT i awighad and diluna
    in wght Ia dividad by numb1r d dose Dr. Parlanya Shukla
    &
    dispensad Dr. M.P. 8tngh Classes

    (9)Naf Contenta
    Th uniformity in contant o tontainTs oabatch. is
    datrmined y
    tiTA aight tara d containaY. 1ken containuTh ar
    i l d and u wighad

    dilu nu in waght gives tR n contands

    (lo) foam Stability-Depending on ts tybe arOA0O


    OTmuahon
    stabibty oom varis rom. faw AAconds to kouTA 07
    moTA R R stability o ta oom con bs datsrminad by
    Visud evaluaion
    v Datminng hmu takan tor o tartain ma to
    onahrdta foom
    (ji1) Deteymininq Hma token for a uod inhoduud
    into oam to fail
    (v) Uzing otahnad viMomater.

    (1)arhicl Sine Datnminahon


    Mean uamant c porhicl sie d aRTOAO is many
    don by oo mahods-

    i Cacod: Tmpocdo Mahod


    Parhtus aT rojaetsd kough a a&riLs anozzlss and
    aJaw &lidus af a VA hiqh vslou ty.
    Th JoTq4T paTicdus ars colctad iat a low
    veloity sBaqe and omallur porkclis or Dr. Parjanya Shukla
    &
    colludad o kigh valouk Hate.
    Dr. M. P. 8ingh Clasaea

    i) lighB -Scaty Dacay T h arHcl Aiz is datarminud by


    muauin4 chang in intanaity o Tyndall btom

    afty agTOAOJ is allowad to sath unday tusbuent


    ComdiHona.

    (12 Biological TostsTis tast in pa7fomad to evaluate


    R Reropuic a4fiuiany and toxicity
    o tK aRYOAOJ rodu c .

    Thrna pauhc Ackvity


    Th doraqe oroduch Kas to b datsrmi nud oT
    inhalahomagrosoJs and Kis musk ba sdatd to
    avHclu he dishbubon.

    Topical praporabons oT appbiid to tesB aas in K


    Aual manner and asovphon oKerapeubic agenh can
    b delrminud.

    i) Toxicity Toxiuky 4eing Ahould indude both topical


    and inhalabm o4ac
    xlerOpols appliad topically may be initaing and /oT
    CausLs chilng allach

    xTnbalahm toxiiby must bs don by expasing test


    animals to vapouIA spiayad om an aToD containst.

    By-Dr. Makndra Pratab Sing&

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