BPH_E_811_T – Novel Drug Delivery Systems- (4 Hr/Wk)

Course Objectives
To provide the learner with knowledge of basic principles and the different types of Novel
Drug Delivery Systems
Course Outcomes
Upon completion of the course, the learner shall be able to:
1. Understand the basic concept of NDDS
2. Discuss the different NDDS for different routes-oral, transdermal, ocular, transmucosal and
implantable
3. Explain the need and concepts of targeting and active & passive targeting
4. Elaborate on principles and targeting systems for brain, colon, lymphatics and tumors
5. Discuss the various multiparticulate systems for targeting
Sr. Topic Book to be No.
N referred of
o. hour
s
1 Fundamentals of Novel drug delivery systems: --Novel drug 1
Basic Concepts delivery systems,
Advantages and Disadvantages, edited by Yie W.
Limitations of conventional dosage Chein, Marcel
forms dekker series, Vol
50

--Novel drug
delivery system
by Prof. A.K.
Bandyopadhyay

2 Polymers: Controlled and 3

Introduction Novel drug
Classificati delivery. Edited
on, by N.K. Jain
Role and applications in NDDS
Biodegradable and biocompatible
polymers.
3 Particulate NDDS: Microspheres, liposomes, nanoparticles, --Colloidal drug 4
aquasomes, niosomes, dendrimers-Classification, components & delivery, edited
design, methods of by Jory Kreuter,
preparation, characterization and applications of each system Marcel Dekker
series, vol. 66

--Targeted
controlled drug
delivery novel
carriers systems
Ed. S. P. Vyas,
R.K. Khar
 Oral Controlled Drug Delivery Systems: --Novel drug 8
4 a) Matrix and reservoir systems- Diffusion and dissolution- delivery systems,
controlled systems edited by Yie W.
b) Multi particulate drug delivery systems (Pellets)- need and Chein, Marcel
significance of pelletization, techniques- pan coating, extrusion dekker series, Vol
and spheronization, equipments, evaluation 50
c) Osmotic Systems- Basic principles, classification-
Implantable osmotic pumps, oral osmotic pumps, applications --Modern
& evaluation Pharmaceutics,
d) Gastro retentive drug delivery systems (GRDDS)- Regional edited by
variability in intestinal absorption and concept of absorption Bankers and
window, Design of GRDDS technologies- low density (Floating Rhodes, 4th
systems), Swelling and expanding systems, Mucoadhesive systems, edition, Informa
high density systems. Evaluation of GRDDS.. Healthcare, Vol.
121

--Remington’s
Science and
Practice of
Pharmacy

--Controlled drug
delivery, concepts
& advances
Suresh P. Vyas
and Roop K.
Khar
--Novel drug
delivery system
by Prof. A.K.
Bandyopadhyay

--Progress in
Controlled and
Novel Drug
Delivery Systems
- by N.K. Jain
5 Ocular drug delivery systems: --Modern 4
Limitations of conventional systems, in situ gelling systems, Ocular Pharmaceutics,
inserts: Non-erodible and Erodible inserts edited by
Particulate systems for ocular delivery-liposomes & Bankers and
nanoparticles, ocular iontophoresis, evaluation. Rhodes, 4th
One example of each system edition, Informa
healthcare,
Special edition,
 Vol. 121
--Controlled and
Novel drug
delivery. Edited
by N.K. Jain

6 Transdermal Drug Delivery Systems --Novel drug 4

(TDDS): Permeation through skin, delivery systems,
Factors affecting permeation, Advantages and disadvantages of TDDS edited by Yie W.
Basic components of TDDS Chein, Marcel
Different types of TDDS and release control mechanism, pressure dekker series, Vol
sensitive adhesives, Evaluation 50

--Controlled and
Novel drug
delivery. Edited
by N.K. Jain
--Novel drug
delivery system
by Prof. A.K.
Bandyopadhyay
7 Transmucosal drug delivery systems: --Novel drug 4
Concept of bioadhesion/ mucoadhesion delivery systems,
Advantages and disadvantages of transmucosal drug edited by Yie W.
delivery, Bioadhesive polymers Chein, Marcel
Theories of mucoadhesion dekker series, Vol
Factors affecting mucoadhesion transmucosal permeability, 50
Formulation considerations: emphasis on buccal drug delivery,
Evaluation of mucoadhesive strength --Controlled and
Novel drug
delivery. Edited
by N.K. Jain
--Novel drug
delivery system
by Prof. A.K.
Bandyopadhyay
Parenteral Controlled drug delivery systems- --Novel drug 5
8 Need and Various approaches, Details of Implantable Systems – delivery systems,
employed, diffusion-controlled systems, activation-controlled systems edited by Yie W.
and feedback-regulated systems. One example of each. Chein, Marcel
Biocompatibility issues of implantable systems dekker series, Vol
50

--Controlled drug
delivery, concepts
& advances
Suresh P. Vyas
and Roop K.
 Khar

9 Nasal and Pulmonary Drug Delivery Systems --Novel drug 7

Advantages and limitations delivery systems,
Nasal drug delivery-absorption pathways of intranasally administere edited by Yie W.
intranasal formulations Chein, Marcel
Nose-to-brain delivery Pulmonary delivery- Weibel model of dekker series, Vol
Lungs (Pulmonary tree), aerosol deposition mechanisms and pattern 50
in --Controlled drug
lungs, concepts of mass median aerodynamic diameter (MMAD) and delivery, concepts
Fine particle fraction (FPF); & advances
Delivery systems (nebulised, systems, pMDIs and DPIs), Suresh P. Vyas
Active and Passive devices, Evaluation methods. and Roop K.
Khar
--Advances in
controlled and
Novel drug
delivery Edited
by NK Jain 2001
--Novel drug
delivery system
by Prof. A.K.
Bandyopadhyay

10 Targeted drug delivery systems: --Novel drug 8

a) Introduction to targeting, concepts of active and passive targeting. delivery systems,
b) Particulate systems for targeting- microspheres, edited by Yie W.
aquasomes, niosomes, dendrimers, and solid lipid Chein, Marcel
nanoparticles, liposomes dekker series, Vol
c) Targeting to colon: Difficulties in colonic targeting, Approaches 50
of colon targeting, Evaluation --Modern
d) Targeting to Brain: Blood brain barrier (BBB), transport Pharmaceutics,
through BBB, factors affecting drug permeation through BBB, edited by
strategies for brain drug delivery Bankers and
e) Lymphatic targeting-need and approaches Rhodes, 4th
f) Targeting to tumor – EPR effect, ligand-based active targeting edition, Informa
with two examples Healthcare,
Special edition,
Vol. 121

--Targeted
controlled drug
delivery novel
carriers systems
Ed. S. P. Vyas,
R.K. Khar

--Advances in
 controlled and
Novel drug
delivery Edited
by NK Jain -
2001
--Controlled and
Novel drug
delivery. Edited
by N.K. Jain

1. Targeted controlled drug delivery novel carriers systems

Ed. S. P. Vyas, R.K. Khar
2. Advances in controlled and Novel drug delivery Edited by NK Jain - 2001
3. Controlled drug delivery, concepts & advances
Suresh P. Vyas and Roop K. Khar
4. Controlled and Novel drug delivery. Edited by N.K. Jain
5. Progress in Controlled and Novel Drug Delivery Systems - by N.K. Jain
6. Novel drug delivery system by Prof. A.K. Bandyopadhyay\
7. Modern Pharmaceutics
8. Remington
9. Novel drug delivery system, Marcel Dekker series, Vol 50