Biology

Chapter: 6 Std 12 : Biology

MCQ
//X Section A
• Choose correct answer from the given options. [Each carries 1 Mark] [88]
1. What happen if in code 25 no. UAA mutant or transformed in UAA in 50 amino acid polypeptide gene ?
(A) Make 25 amino acid polypeptide (B) 24 amino acid polypeptide
(C) 24 and 25 amino acid with two polypeptide (D) Polypeptide with 49 amino acid
2. In the dictionary of genetic condons, how many codons are these of 20 amino acids ?
(A) 60 (B) 20 (C) 64 (D) 61
3. DNA fingerprint is associated with ......
(A) to molecular analysis of DNA prints or images.
(B) to analys tech. for DNA printing.
(C) for different DNA model by molecular analysis tech.
(D) for individual fingerprint.
4. In a disorder, when adenine is replaced by guanine is an example of
(A) disorder of change of skeleton (B) transcription
(C) transition (D) transversion
5. Which of the following, uses RNA as a template and synthesis DNA ?
(A) DNA polymerase (B) RNA polymerase
(C) Reverse transcriptase (D) RNA polymerase dependant on DNA
6. In DNA chain growth of Okazaki fragments stands for ..........
(A) by making fork, replication proceeds in 3' to 5' direction.
(B) DNA replication proves the meaning of conservative properties.
(C) it forms in direction of 5' to 3' direction and results in DNA replication in and 3' to 5' direction.
(D) results into transcription.
7. In eukaryotes, the length of DNA molecular increases the volume of cell nucleus. How does this DNA
arrange ?
(A) Getting most higher folds in nucleosomes (B) DNA digestion.
(C) By removing repetitive DNA (D) By removing unwanted genes
8. As per the human genome sequences, expression is ..........
(A) messenger RNA (B) DNA sequences (C) ribosomes (D) transfer - RNA
9. Molecular base transcription of organ differentiation is based on ............
(A) ribosome (B) part of transcription (C) code (D) RNA polymerase
10. In DNA molecule ............
(A) the number of pyrimidine and pyurin nucleotide
(B) two stand which parallel from 5' to 3' direction.
(C) in living organism ademin and thymine ratio is unequals.
(D) in that two strands are antiparallel to each other direction of one is 5' to 3' and other is
3' to 5'.
11. Pair of coding which are according for their function or specific code for amino acid.
(A) GUU, GCU - alanin (B) UAG, UGA - termination code
(C) AUG, ACG - starting code or metheonin (D) UUA, UCA - lucin
12. The pair of nitrogen base of nucleotides are wrong
(A) thymin, uresil - pyrimidine (B) uresil, cytosin - pyrimidine
(C) guanine, adenine - purine (D) adenine, thymin - purine
13. Identify the diagram "a" and "b" given below, and what does "c" and "d" in the given diagram ?
(A) a = Negative regulation b = Positive regulation
“b” “a”
c = Effector molecule d = Inhibitor
(B) a = Positive regulation b = Negative regulation “c”
 Identify the diagram "a" and "b" given below, and what does "c" and "d" in the given diagram ?
(A) a = Negative regulation b = Positive regulation
“b” “a”
c = Effector molecule d = Inhibitor
(B) a = Positive regulation b = Negative regulation “c”
c = Inhibitor d = Effector molecule
(C) a = Positive regulation b = Negative regulation
“d”
c = Effector molecule d = Inhibitor
(D) a = Negative regulation b = Positive regulation
c = Inhibitor d = Effector molecule

14. Which option shows the correct steps for making DNA fingerprinting ?
(A) Separation of DNA fragments by electrophoresis
(B) The DNA band pattern is transferred to nylon membrane or nitro cellulose.
(C) Extraction of DNA from the sample cells.
(D) Restriction digestion DNA is cut into sections by using restriction endonuclease.
(A) d ® b ® c ® a (B) c ® d ® a ® b (C) b ® d ® a ® c (D) c ® a ® b ® d
15. Which of the following option is correct for the chronology of various stages of transcription ?
(A) DNA polymerase unite at the place on DNA, where transcriptase is to start ® any one chain acts as
templet ® tRNA get bind wit specific protein.
(B) Transcriptase will unit mRNA at place where transcription is to start ® any one chain will act as
templet ® mRNA unite with specific protein.
(C) Transcriptase will unite on DNA at the place where transcription is to start ® one of these two chains
acts as template ® specific protein get bind to RNA.
(D) None of the given.
16. DNA replication is called semi-conservative why ..........
(A) At the end of replication each RNA possesses one parental chain and the other newly synthesized chain.
(B) At the end of replication each DNA molecule is consist of one parent DNA chain and the other newly
synthesized DNA chain
(C) After replication each DNA molecule is synthesized from parental strand.
(D) At the end of DNA is replication only half DNA is synthesized
17. Which option is correct for the statements given in reference to the daughter strand formed at the
region labelled as "X" in the given diagram ?
3'
(i) In it first of all DNA polymerase forms primer
5'
(ii) After primer is formed, DNA polymerase III is activated
(iii) Ligase is important at the end of synthesis of strand5' 3'
(iv) Here many primers are formed for synthesis of strand 3' 5'
Template DNA
(A) (ii), (iii)
(Parental Strand)
(B) (i), (ii), (iii)
‘x’
(C) (ii), (iii), (iv) 3'
5'
(D) (i), (iii), (iv)
18. Which gene is present on part of DNA in Lac Operon ?
(A) Structural gene (B) Regulator gene (C) Promotor gene (D) Operator gene
19. Give the correct labelling of X, Y and Z with the following diagram of central Dogma.
(A) X : Translation, Y : Elongation, Z : Erwin Chargaff
(B) X : Transcription, Y : Replication, Z : D. Baltimore [X] [Y]
DNA RNA Protein [Z]
(C) X : Translation, Y : Transcription, Z : H.M. Temin
(D) X : Transcription, Y : Translation, Z : F.H.C. Crick Replication (Scientist’s name)
20. STOP signals are seen on ...... .
(A) None of the given (B) t - RNA (C) m - RNA (D) r - RNA
21. Which enzyme is produced for the digestion of Lactose by the ‘a’ side of structural gene as a resulting
transcription of Lac mRNA when represser molecule is not joined with operator (O) ?
(A) Transacetylase (B) Transcyclase (C) p - Galactosidase (D) Permease
 Which enzyme is produced for the digestion of Lactose by the ‘a’ side of structural gene as a resulting
transcription of Lac mRNA when represser molecule is not joined with operator (O) ?
(A) Transacetylase (B) Transcyclase (C) p - Galactosidase (D) Permease

22.
X Y Z

What is X, Y, Z in the given figure of DNA.

(A) X - Promotor, Y - Coding sequence, Z - Initiation site.
(B) X - Termination site, Y - Coding sequence, Z - Promotor.
(C) X - Promotor, Y - Coding sequence Z - Termination site.
(D) X - Termination site, Y - Coding sequence, Z - Initiation site.
23. Give the correct essential enzyme synthesized when lactose sugar is added to the culture of
E-coli for the conversion of lactose into galactose.
(A) Trans-acetylase (B) Permease
(C) Reverse transcriptase (D) Both Trans-acetylase and permease
24. For the statements given for genetic code, which of the below given option is correct ?
Statement P : The sequence of genetic codes and the sequence of amino acids in protein molecules do
not show linear parallelism.
Statement Q : Genetic code is universal.
Statement R : Genetic code is specific, one codon specifies the position of many kinds of amino acids.
(A) Statement P is false and Statement Q, R are true.
(B) Statement P, Q are true, Statement R is false.
(C) Statement P, R are true, Statement Q is false.
(D) Statement P, R are false, Statement Q is true.
25. Which amino acid is having three genetic codes ?
(A) Leu (B) Ileu (C) Phe (D) Gly
26. Identify the name of X and Y in transfer RNA loop.
(A) X = Variable loop, Y = D loop
(B) X = Anticodon loop, Y = D loop
(C) X = Anticodon loop, Y = Acceptor chain
Y
(D) X = D loop, Y = Variable loop

X Y
27. DNA mRNA Protein

Name the process X and Y given in the given flow chart.

(A) X = Translation, Y = Transcription (B) X = Transcription, Y = Translation
(C) X = Gene synthesis, Y = Transcription (D) X = Gene transcription, Y = Gene isolation
28. What is “A” and “B” in given diagram ?
(A) A = RNA Primer B = RNA Helicase
(B) A = RNA Primer B = DNA Helicase
(C) A = Single strand Binding Protein B = DNA Helicase A

(D) A = Lagging strand B = Movement of Helicase

29. Which amino acid determines by four genetic codes ?

(A) Leucine (Leu) (B) Proline (Pro) (C) Serine (Ser) (D) Tyrosine (Tyr)
30. A : The DNA fingerprint is the same for every cell, tissue and organ of a person.
R : DNA fingerprint is used for treatment of inherited disorders like Huntigton’s disease, Alzheimer’s and
Sickle cell anemia.
(A) A and R both are correct. R is explanation of A.
(B) A and R both are correct but R is not explanation of A.
(C) A is correct and R is wrong.
(D) A is wrong and R is correct.
31. Gene regulation governing lactose operon of E-coli that involves the lac I gene product is :
(A) Positive and inducible because it can be induced by lactose
(B) Negative and inducible because repressor protein prevents transcription.
(C) Negative and repressible because repressor protein prevents transcription.
(D) Feedback inhibition because excess of b-glactosidase can switch off transcription
32. When mice were injected with a mixture of bacteria, avirulent pneumococcus bacteria and heat killed
virulent, the mice were found dead due to pneumococcus infection. Why ?
(A) Avirulent bacteria were destroyed by virulent bacteria
(B) Avirulent stain transformed into virulent by entering in mice
(C) Something from the virulent bacteria was transformed to the live avirulent bacteria as a result the
avirulent bacteria transformed into virulent bacteria.
(D) Heat killed pneumococcus bacteria injected in mice, transformed to the live bacteria.
33. How many types of anticodons are present ?
(A) Uncountable (B) 61 (C) 03 (D) 64
34. In transcription why only one mRNA is synthesized from two DNA chains ?
(A) One mRNA is synthesized by combined effect of two chains.
(B) Both DNA chains act as DNA template
(C) Out of two DNA chains, one acts as a template chain
(D) Both the DNA chains become united and make one
35. Who has proposed the rule - [A] + [G] = [T] + {C], for ratio of Nucleotides ?
(A) Dr. Hargovind Khorana (B) Crick and Wilkins
(C) Erwin Chargaff (D) Watson and Crick
36. According to observations of Human Genome project, which chromosome has minimum
genes ?
(A) On somatic chromosome (B) in Y
(C) Both X Y (D) in X
37. ) In DNA Replication Okazaki Fragments are made up of -
(A) DNA and tRNA (B) DNA and RNA Polymerase
(C) DNA and RNA Primer (D) DNA and DNA Helicase
38. ) In Biological Evolution macro-molecules undergo aggregation and precipitation, which led to formation
of organised structure called...
(A) Nucleic Acid (B) Cell (C) Coacervates (D) Precell
 ) In Biological Evolution macro-molecules undergo aggregation and precipitation, which led to formation
of organised structure called...
(A) Nucleic Acid (B) Cell (C) Coacervates (D) Precell
39. ) In eukaryote what is the initiation codon for protein synthesis.
(A) GUA (B) GCA (C) CCA (D) AUG
40. ) DNA template strand having the sequences CTG/ATAGC which will complementary with RNA of which
sequences ?
(A) GUCTUTCG (B) GACUAUCG (C) GAUTATUG (D) UACTATCU
41. ) The pair of anticodons do not exist in such nitrogenous bases, whose triplet codons occurs in open
situation in ............
(A) m-RNA (B) r-RNA (C) t-RNA (D) s-RNA
42. ) In prokaryotic a during initiation of translation, GTP is essential in ............
(A) the attachment of 505 subunit of ribosome to initiation complex.
(B) production of fomyl methio t-RNA
(C) the attachment of 305 subunit of ribosomes to m-RNA
(D) the attachment of 305 m-RNA to fomyl methio t-RNA.
43. ) The given triplet codons in protein synthesis, are true for their amino acids or are initiation of
termination codons ?
(A) UAC - tyrosine (B) UCG - initiation (C) UUU - termination (D) UGU - lucine
44. ) During replication of bacterial chromosome, replication starts with origin and ............
(A) RNA primer takes part (B) it is facilitated by telomeres
(C) moves in one direction only (D) moves in two direction
45. ) In genetically mutated organisms, the expression of newly formed genes in particular tissue is decided
by ............
(A) enhancer (B) trans gene (C) promoter (D) reporter
46. ) The E-coil cells, having ‘2’ gene in lac operon do not grow on medium containing lactose as sole source
of energy because,
(A) in these cell, lac operon is active.
(B) they cannot synthesis active b-galactosidase
(C) E-coli cell do not utilize lactose in presence of glucose
(D) they cannot transfer lactose from medium into the cells.
47. ) Which enzyme/s will be produced in a cell in which there is a non-sense mutation in the lac Y-gene ?

(A) b-galactosidase (B) Lactose permease

(C) Transacetylase (D) Lactose permease and transacetylase
48. ) The diagram shows an important concept in the genetic implication of DNA. Fill in the blanks A to C.
(A) A-transcription, B-replication, C-James Watson
(B) A-translation, B-transcription, C-Erwin Chargaff A B Proposed by
(C) A-transcription, B-translation, C-Francis Crick DNA mRNA Protein
C
(D) A-translation, B-extension, C-Rosalind Franklin
49. ) Transformation was discovered by
(A) Meselson and Stahl (B) Hershey and Chase (C) Griffith (D) Watson and Crick
50. ) Which one of the following is wrongly matched ?
(A) Transcription-Writing information from DNA to tRNA.
(B) Translation-Using information in mRNA to make protein
(C) Repressor protein-Binds to operator to stop enzyme synthesis
(D) Operon-Structural genes, operator and promoter
51. ) Satellite DNA is important because it
(A) codes for proteins needed in cell cycle
(B) shows high degree of polymorphism in population and also the same degree of polymorphism in
an individual, which is heritable from parents to children
(C) does not code for proteins and is same in all members of the population
 (A) codes for proteins needed in cell cycle
(B) shows high degree of polymorphism in population and also the same degree of polymorphism in
an individual, which is heritable from parents to children
(C) does not code for proteins and is same in all members of the population
(D) codes for enzymes needed for DNA replication
52. ) Identify the correct order of organisation of genetic material from largest to smallest.
(A) Chromosome, gene, genome, nucleotide (B) Genome, chromosome, nucleotide, gene
(C) Genome, chromosome, gene, nucleotide (D) Chromosome, genome, nucleotide, gene
53. ) Which one of the following is not applicable to RNA ?
(A) Complementary base pairing (B) 5' phosphoryl and 3' hydroxyl ends
(C) Heterocyclic nitrogenous bases (D) Chargaff's rule
54. ) Taylor conducted the experiments to prove semiconservative mode of chromosome replication on
(A) Vinca rosea (B) vicia faba
(C) Drosophila melanogaster (D) E. coil
55. ) The equivalent of a structural gene is
(A) muton (B) cistron (C) operon (D) recon
56. ) Which of the following rRNAs act as structural RNA as well as ribozyme in bacteria ?
(A) 5 srRNA (B) 18 srRNA (C) 23 srRNA (D) 5-8 srRNA
57. ) A molecule that can act as a genetic material must fulfill the traits given below, except
(A) it should be able to express itself in the form of 'Mendelian characters'
(B) it should be able to generate its replica
(C) it should be unstable structurally and chemically
(D) it should provide the scope for slow changes that are required for evolution
58. ) DNA-dependent RNA polymerase catalyses transcription on one strand of the DNA which is called the
(A) template strand (B) coding strand (C) alpha strand (D) anti strand
59. ) Which of the following is required as inducer(s) for the expression of lac operon ?
(A) galactose (B) lactose (C) lactose and galactose (D) glucose
124) Which of the following is not required for any of the techniques of DNA fingerprinting available at present ?
60.
(A) Zinc finger analysis (B) Restriction enzymes
(C) DNA-DNA hybridisation (D) Polymerase chain reaction
61. ) A complex of ribosomes attached to a single strand of RNA is known as
(A) polymer (B) polypeptide (C) okazaki fragment (D) polysome
62. ) Which one of the following is the starter codon ?
(A) UGA (B) UAA (C) UAG (D) AUG
63. ) Which of the following RNAs should be most abundant in animals cell ?
(A) rRNA (B) tRNA (C) mRNA (D) miRNA
64. ) DNA replication in bacteria occurs
(A) during S-phase (B) within nucleolus
(C) prior to fission (D) just before transcription
65. ) Spliceosomes are not found in cells of
(A) plants (B) fungi (C) animals (D) bacteria
66. ) The association of histone H1 with a nucleosome indicates
(A) transcription is occurring (B) DNA replication is occurring
(C) the DNA is condensed into chromatin fibre (D) the DNA double helix is exposed
67. ) The final proof for DNA as the genetic material came from the experiments of
(A) Griffith (B) Hershey and Chase
(C) Avery, MacLeod and McCarty (D) Hargobind Khorana
68. ) If there are 999 bases in an RNA that codes for a protein with 333 amino acids and the base at position
901 is deleted such that the length of the RNA becomes 998 bases, how many codons will be altered ?
(A) 1 (B) 11 (C) 33 (D) 333
69. ) All of the following are part of an operon except
(A) a promoter (B) an operator (C) an enhancer (D) structural genes
70.4) AGGTATCGCAT is a sequence from the coding strand of a gene. What will be the corresponding sequence
of the transcribed mRNA ?
(A) UCCAUAGCGUA (B) AGGUAUCGCAU (C) ACCUAUGCGAU (D) UGGTUTCGCAT
 4) AGGTATCGCAT is a sequence from the coding strand of a gene. What will be the corresponding sequence
of the transcribed mRNA ?
(A) UCCAUAGCGUA (B) AGGUAUCGCAU (C) ACCUAUGCGAU (D) UGGTUTCGCAT
71. ) Select the correct match :
(A) Francois Jacob and– Lac operon Jacques Monod (B) Alec Jeffreys – Streptococcus pneumonia
(C) Matthew Meselson and – Pisum sativum F. (D) Alfred Hershey and – TMV Martha Chase
72. ) The experimental proof for semiconservative replication of DNA was first shown in a
(A) Virus (B) Fungus (C) Plant (D) Bacterium
73. ) Purines found both in DNA and RNA are :
(A) Adenine and thymine (B) Adenine and guanine
(C) Guanine and cytosine (D) Cytosine and thymine
74. ) Under which of the following conditions will there be no change in the reading frame of following
mRNA ?
(A) Insertion of G at 5th position
(B) Deletion of G from 5th position
(C) Insertion of A at G at 4th and 5th positions respectively
(D) Deletion of GGU from 7th, 8th and 9th positions
75. ) Expressed Sequence Tages (ESTs) refers to :
(A) Genes expressed as RNA (B) Polypeptide expression
(C) DNA polymorphism (D) Novel DNA sequences
76. ) A gene locus has two alleles A, a. If the frequency of dominant allele A is 0.4 then what will be the
frequency of homozygous dominant, heteroz-ygous and homozygous recessive individuals in the
population ?
(A) 0.36 (AA); 0.48(Aa); 0.16 (aa) (B) 0.16 (AA); 0.24 (Aa); 0.36 (aa)
(C) 0.16 (AA); 0.48 (Aa); 0.36 (aa) (D) 0.16 (AA); 0.36 (Aa); 0.48 (aa)
77. ) Match the following genes of the Lac operon with their respective products.
(A) i gene (i) b-galactosidase
(B) z gene (ii) Permease
(C) a gene (iii) Repressor
(D) y gene (iv) Transacetylase
Select the correct option.
A B C D A B C D
(A) (i) (iii) (ii) (iv) (B) (iii) (i) (ii) (iv)
(C) (iii) (i) (iv) (ii) (D) (iii) (iv) (i) (ii)
78. ) If the distance between two consecutive base pairs is 0.34 nm and the total number of base pairs of a
DNA double helix in a typical mammalian cell is 6.6 × 109 bp, then the length of the DNA is
approximately.
(A) 2.5 meters (B) 2.2 meters (C) 2.7 meters (D) 2.0 meters
79. ) Name the enzyme that facilitates opening of DNA helix during transcription.
(A) DNA helicase (B) DNA polymerase (C) RNA polymerase (D) DNA ligase
80. ) The first phase of translation is :
(A) Recognition of DNA molecule (B) Aminoacylation of tRNA
(C) Recognition of an anti-codon (D) Binding of mRNA to ribosome
145) N-Glycosidic linkage contains
81.
(A) Triglyceride (B) Dipeptide (C) Disaccharide (D) Nucleoside
82. ) 5-Methyl uracil means ...........
(A) Guanine (B) Uracil (C) Thymine (D) Cytosine
83. ) The Genome containing all the coding and non coding sequence with function is termed as ............
(A) Bacterial artificial chromosomes (B) Sequence Annotation
(C) Expressed sequence Tags (D) Yeast artificial chromosomes
84. ) How many hydrogen bonds are formed in a DNA molecule between nitrogen base with 50 nitrogen base
pairs in which thymine is 20 ?
(A) 50 (B) 90 (C) 40 (D) 130
 ) How many hydrogen bonds are formed in a DNA molecule between nitrogen base with 50 nitrogen base
pairs in which thymine is 20 ?
(A) 50 (B) 90 (C) 40 (D) 130
85. ) If DNA template is having ACG nitrogen bases what will be the anticodon of tRNA ?
(A) TCG (B) ACG (C) UGC (D) UAC
86. ) Which option shows degenerate codons ?
(A) AAU, AUG, AAG (B) UGG, UGC, UCG (C) GUU, GUC, GUA (D) UGU, UGG, UGA
87. ) 'Central dogma' was proposed by X and these are the processes Y , Z comes in it respectively..
Choose the correct option.
(A) X - Frederich Griffith Y - transformation Z - transcription
(B) X - Watson & Crick Y - transformation Z - replication
(C) X - Francis Crick Y - transcription Z - translation
(D) X - Hershey & Chase Y - replication Z - translation
88. ) In 'Lac Operon' concept, the structural genes (z, y and a) will code for the following enzymes
respectively :
(A) b - galactosidase; permease; transacetylase
(B) b - galactosidase; lipase; transacetylase
(C) b - galactosidase; carboxylase; transacetylase
(D) b - galactosidase; permease; acetylase
 Biology
Chapter: 6 Std 12 : Biology
MCQ
//X Section A
• Choose correct answer from the given options. [Each carries 1 Mark] [88]
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