Elixirs are clear, sweetened liquids intended for oral use that contain flavorings and/or active pharmaceutical ingredients dissolved in a mixture of water and alcohol. There are two main types - medicated elixirs, which contain active ingredients, and non-medicated elixirs, which are used as flavored vehicles to dilute other medications. Elixirs are typically prepared through simple admixture and agitation of the ingredients to form a solution, taking care to avoid excessive heat since alcohol is volatile. Common solvents used include purified water, alcohol, glycerin, and propylene glycol.
Elixirs are clear, sweetened liquids intended for oral use that contain flavorings and/or active pharmaceutical ingredients dissolved in a mixture of water and alcohol. There are two main types - medicated elixirs, which contain active ingredients, and non-medicated elixirs, which are used as flavored vehicles to dilute other medications. Elixirs are typically prepared through simple admixture and agitation of the ingredients to form a solution, taking care to avoid excessive heat since alcohol is volatile. Common solvents used include purified water, alcohol, glycerin, and propylene glycol.
Elixirs are clear, sweetened liquids intended for oral use that contain flavorings and/or active pharmaceutical ingredients dissolved in a mixture of water and alcohol. There are two main types - medicated elixirs, which contain active ingredients, and non-medicated elixirs, which are used as flavored vehicles to dilute other medications. Elixirs are typically prepared through simple admixture and agitation of the ingredients to form a solution, taking care to avoid excessive heat since alcohol is volatile. Common solvents used include purified water, alcohol, glycerin, and propylene glycol.
Elixirs are clear, sweetened liquids intended for oral use that contain flavorings and/or active pharmaceutical ingredients dissolved in a mixture of water and alcohol. There are two main types - medicated elixirs, which contain active ingredients, and non-medicated elixirs, which are used as flavored vehicles to dilute other medications. Elixirs are typically prepared through simple admixture and agitation of the ingredients to form a solution, taking care to avoid excessive heat since alcohol is volatile. Common solvents used include purified water, alcohol, glycerin, and propylene glycol.
Pharmaceutical Dosage Forms, Drug Delivery Systems and Medical Devices M
Elixirs
Non- Aqueous Liquids: Elixirs Alcohol, USP
- 94.9 – 95% Ethanol/ Ethyl alcohol. Definition - Primary solvent for organic compounds. What are elixirs? - Used if the ingredients are not soluble in - Clear, sweetened hydroalcoholic intended water. for oral use containing flavoring substance ● Miscible with water, glycerin and propylene or active medicinal agent. glycol. - Primary solvents are water and alcohol ● It is volatile in nature. - Glycerin, sorbitol and syrup – additional solvent or sweetening agents. - 10-12% self-preserving - 5-40% (limit) - Used as vehicle or for their Types therapeutic effect Medicated Elixirs - with active pharmaceutical ingredients Propylene Glycol - Can be used as a cosolvent or additional Example: solvent. ● Acetaminophen elixir, hyoscyamine elixir - Miscible with water and alcohol. and Digoxin elixir - Viscous liquid - Can be a substitute for glycerin and alcohol Non-Medicated Elixirs - Used for extemporaneous filling of Method of Preparation prescriptions. Can be used as a flavored Agitation with aid of Heat vehicle or used to dilute existing medicated - Simple solution with agitation. elixir. Admixture of 2 or more liquids Example: - Since in the preparation of elixirs alcohol is ● Aromatic Elixir, iso-alcoholic elixir and always used it is said that pharmacists tend compound benzaldehyde to prevent the use of heat in preparing the elixir since alcohol is known to be volatile in Purified Water, USP nature. - Most common solvent used ● Lacks toxicity. Iso-alcoholic Elixir ● Compatible and can dissolve most of the - Iso-alcoholic elixir ingredients used as pharmacologic agents. - Non medicated elixir ● The only disadvantage water has is its prone to microbial growth/ microbial Uses contamination. - General vehicle for various medicaments that requires solvent of different alcohol - Purified water is mostly used in drug strength preparation with the exemption for parenteral products such as injections the Method Used for the Preparation water used here is water for injection. - Admixture of 2 or more liquids ● pH 5-7 ● Methods of manufacture: distillation, reverse osmosis, ion exchange treatment