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Drug Study - Penicillin G

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DRUG STUDY

NAME OF DRUG CLASSIFICATION INDICATIONS SIDE EFFECTS NURSING IMPLICATIONS


Management for:  Before giving, ask patient
Generic name: systemic infections caused by  muscle spasms about allergic reactions to
Penicillin G Pharmacologic class: Penicillin gram-positive organisms  fever penicillin, cephalosporins,
Therapeutic class: Antibiotic (including Bacillus anthracis,  chills and cephamycin.
Brand name: Pregnancy risk category: B Corynebacterium diphtheriae,  muscle pain  Watch for seizures; notify
Pfizerpen enterococci, Listeria  headache physician immediately if
monocytogenes, Staphylococcus  tachycardia patient develops or
aureus, and S. epidermidis), gram-  flushing increases seizure activity.
negative organisms (including  Monitor signs of allergic
 tachypnea
MECHANISM OF ACTION Neisseria gonorrhoeae, N. reactions and anaphylaxis,
DOSAGE  hypotension
meningitidis, Pasteurella including pulmonary
 dizziness
2 million “u” Inhibits final stage of bacterial multocida, and Streptobacillus symptoms (tightness in the
moniliformis [rat-bite fever]), and  diarrhea
cell wall synthesis by throat and chest,
gram-positive anaerobes  nausea
competitively binding to wheezing, cough dyspnea)
(including Actinomyces israelii  vomiting
penicillin-binding proteins inside or skin reactions (rash,
[actinomycosis], Clostridium  allergic reactions (itching, prurits, urticaria). Notify
the cell wall. Penicillin-binding
perfringens, C. tetani, Peptococcus rash, anaphylaxis) physician or nursing staff
proteins are responsible for
various steps in bacterial cell wall species, Peptostreptococcus immediately if these
species, and spirochetes, ADVERSE EFFECTS
synthesis. By binding to these reactions occur.
especially Treponema carateum CNS: seizures, dizziness,
proteins, penicillin leads to cell  Assess muscle aches and
[pinta], T. pallidum, and T. headache, lethargy
wall lysis. joint pain (arthralgia) that
pertenue [yaws]) GI: Abdominal pain, diarrhea,
may be caused by serum
nausea, pseudomembranous
sickness. Notify physician
CONTRAINDICATIONS colitis
if these symptoms seem to
• Contraindicated in patients GU: Acute interstitial nephritis, be drug related rather than
with hypersensitivity to penicillin vaginal candidiasis caused by musculoskeletal
or its components SKIN: Rash
injury or if muscle and
Other: Electrolyte imbalances;
joint pain are
injection-site necrosis, pain, or
accompanied by allergy-
redness
like reactions (fever,
rashes, etc.)

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