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  • 7 Midazozalam Drug Study

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    Midazolam is a short-acting benzodiazepine hypnotic-sedative drug that is indicated for promoting preoperative sedation, anxiolysis, anesthesia induction, amnesia, and treatment of status epilepticus in adults. It works by enhancing the effects of the neurotransmitter GABA to produce sedative, anxiolytic, amnestic, muscle relaxant, and hypnotic effects. Common side effects include decreased respiratory rate, tenderness at injection site, and oxygen desaturation. Nurses must monitor vital signs and respiratory status during and after administration due to risks of respiratory depression, apnea, and hypotension from improper dosing.

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    Midazolam is a short-acting benzodiazepine hypnotic-sedative drug that is indicated for promoting preoperative sedation, anxiolysis, anesthesia induction, amnesia, and treatment of status epilepticus in adults. It works by enhancing the effects of the neurotransmitter GABA to produce sedative, anxiolytic, amnestic, muscle relaxant, and hypnotic effects. Common side effects include decreased respiratory rate, tenderness at injection site, and oxygen desaturation. Nurses must monitor vital signs and respiratory status during and after administration due to risks of respiratory depression, apnea, and hypotension from improper dosing.

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    74 views3 pages

    7 Midazozalam Drug Study

    Uploaded by

    shadow gonzalez
    Midazolam is a short-acting benzodiazepine hypnotic-sedative drug that is indicated for promoting preoperative sedation, anxiolysis, anesthesia induction, amnesia, and treatment of status epilepticus in adults. It works by enhancing the effects of the neurotransmitter GABA to produce sedative, anxiolytic, amnestic, muscle relaxant, and hypnotic effects. Common side effects include decreased respiratory rate, tenderness at injection site, and oxygen desaturation. Nurses must monitor vital signs and respiratory status during and after administration due to risks of respiratory depression, apnea, and hypotension from improper dosing.

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    of 3

    Midazolam

    A Drug Study Presented to


    Lendell Kelly B. Ytac, RN
    Faculty, INAHS BSN-Program
    Davao Oriental State University

    _____________________________________________

    In Partial Fulfillment
    of the requirements for
    NCM 118
    Care of Clients with Life Threatening Conditions, Acutely Ill / Multi-Organ Problems,
    High Acuity and Emergency Situations

    By

    Clint S. Ancog
    Student Nurse, BSN-4

    October 12, 2022


    Name of Drug Dosage/ Mechanism of Indication Contraindication Side Effects/ Nursing
    Frequency/ Action Adverse Effects Responsibilities
    Time/ Route
    Generic Name: Continuous Enhances action of Indicated for Hypersensitivity SIDE EFFECTS: BASELINE
    Midazolam Sedation During gamma- promoting to midazolam. Frequent (10%– ASSESSMENT
    Mechanical aminobutyric acid preoperative Acute narrow- 4%): Decreased Resuscitative
    Brand Name: Ventilation (GABA), one of the sedation, angle glaucoma, respiratory rate, equipment, oxygen
    Versed major inhibitory anxiolysis, concurrent use of tenderness at IM or must be available.
    IV: ADULTS, neurotransmitters in anesthesia protease IV injection site, Obtain vital signs
    Drug ELDERLY: the brain. induction, or inhibitors (e.g., pain during before
    Classification: Initially, 0.01– Therapeutic amnesia. atazanavir, injection, oxygen administration.
    Midazolam is in a 0.05 mg/kg (1–5 Effect: Produces Indicated for darunavir). desaturation, Assess level of
    class of mg in 70-kg anxiolytic, the treatment hiccups. consciousness.
    medications called adult). May hypnotic, of status Cautions:
    benzodiazepines. It repeat at 5- to anticonvulsant, epilepticus in Renal/hepatic/pul Occasional (3%- INTERVENTION/
    works by slowing 15-min intervals muscle relaxant, adults. monary 2%): Hypotension, EVALUATION
    activity in the until adequate amnestic effects. impairment, paradoxical CNS Monitor
    brain to allow sedation impaired gag reaction. respiratory rate,
    relaxation and achieved or Pharmacokinetics: reflex, HF, treated oxygen saturation
    sleep. continuous Well absorbed after open-angle Rare (less than 2%): continuously
    infusion rate of IM administration. glaucoma, obese Nausea, vomiting, during parenteral
    Chemical make-up headache, coughing. administration for
    0.02–0.1 Protein binding: pts, concurrent
    and effect: underventilation,
    mg/kg/hr and 97%. Metabolized CNS depressants,
    Midazolam is a ADVERSE apnea. Monitor
    titrated to in liver. Primarily alcohol
    short-acting EFFECTS: vital signs, level of
    desired effect. excreted in urine. dependency,
    hypnotic-sedative Inadequate or sedation q3–5min
    Not removed by elderly pts,
    drug with excessive dosage, during recovery
    CHILDREN: hemodialysis debilitated pts. period. Assess level
    anxiolytic, muscle Initially, 0.05– improper
    of consciousness
    relaxant, 0.2 mg/kg Pharmacodynamic administration may
    for effectiveness.
    anticonvulsant, followed by s: result in cerebral
    sedative, hypnotic, continuous Pharmacodynamic hypoxia, agitation,
    and amnesic infusion of 0.06– properties of involuntary
    properties. 0.12 mg/kg/hr midazolam and its movements,
    hyperactivity,
    (1–2 metabolites, which combativeness. Too-
    mcg/kg/min) are similar to those rapid IV rate,
    titrated to of other excessive doses, or
    desired effect. benzodiazepine single large dose
    Usual range: drugs, include increases risk of
    0.4–9.4 sedative, anxiolytic, respiratory
    mcg/kg/min. amnestic, muscle depression/arrest.
    relaxant, as well as Respiratory
    hypnotic activities. depression/apnea
    Benzodiazepines may produce
    enhance the hypoxia, cardiac
    inhibitory action of arrest.
    the amino acid
    neurotransmitter
    gamma-
    aminobutyric acid
    (GABA).

    References:

    Vermeeren A. (2004). Residual effects of hypnotics: epidemiology and clinical implications. CNS Drugs. Retrived from: https://
    go.drugbank.com/drugs/DB00683

    Kizior R. J., & Hodgson K. J. (2021). Saunders Nursing Drug Handbook 2021. Elsevier. 3251 Riverport Lane. St. Louis, Missouri
    63043.

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