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TCI Sedation Flowsheet

Apply patient monitoring and secure suitable IV access

Connect patient to the TCI pump and commence supplemental O2 at 4 L min-1

INITIAL PHASE: Set CpT at 1.4µg ml-1 and Start TCI propofol (1%). Monitor CeT and assess sedation as CeT
rises to 1.0 µg ml-1, 1.2µg ml-1and 1.4µg ml-1. The patient is likely to be under sedated in this initial phase but
follow the algorithm below if they become adequately sedated or require no further sedation.

If the patient remains under sedated when CpT and CeT = 1.4µg ml-1 then proceed to the TITRATION PHASE.

Assess sedation when CeT is 1.4µg ml-1 Requires no further sedation

Adequately Sedated Under sedated OAA/S 2 (Response only after mild


prodding or shaking) OR
OAA/S 3 (Response only after OAA/S 5 (Responds readily to name OAA/S 1 (Response only after
name is called loudly and/or spoken in normal tone) OR painful trapezius squeeze) OR
repeatedly)
OAA/S 4 (Lethargic response to name OAA/S 0 (No response after
spoken in normal tone) painful trapezius squeeze)
Do not change the pump
settings
Stop infusion and DO NOT give
alfentanil bolus

TITRATION PHASE: If the patient remains under sedated when CpT and CeT =S1.4µg ml-1 then
increase the CpT by 0.2µg ml-1 every 2 minutes to a maximum of 4.0 µg ml-1.

Asses the sedation level every 2 minutes. When CpT is 2.6µg ml-1 then a second healthcare
professional should also assess the sedation level before proceeding further to a maximum
of 4.0 µg ml-1.

If remains OAA/S 5 OR OAA/S 4 at CpT = 4µg ml -1


then STOP STUDY AT THIS POINT
Administer Alfentanil Bolus
COMMENCE REDUCTION
>70kg give 250 µg

50-70kg give 200 µg

On completion of the reduction the infusion should be stopped and the patient observed until complete recovery

If an adverse event occurs, the TCI should be stopped immediately

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