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    Jurnal 1

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    of 2

    Pharmaceutical Sciences

    March 2017, 23, 1-2


    doi: 10.15171/PS.2017.01
    http://journals.tbzmed.ac.ir/PHARM

    Editorial

    Pharmaceuticals Solubility is Still Nowadays Widely Studied


    Everywhere
    Fleming Martínez1*, Abolghasem Jouyban2,3, William E. Acree Jr.4
    1Grupo de Investigaciones Farmacéutico Fisicoquímicas, Departamento de Farmacia, Facultad de Ciencias, Universidad
    Nacional de Colombia –Sede Bogotá, Cra. 30 No. 45-03, Bogotá D.C., Colombia.
    2Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

    3
    Kimia Idea Pardaz Azarbayjan (KIPA) Science Based Company, Tabriz University of Medical Sciences, Tabriz, Iran.
    4Department of Chemistry, University of North Texas, Denton, TX 76203-5070, USA.

    Equilibrium solubility is a thermodynamic property physico-chemical properties such as Abraham or


    of great importance in pharmaceutical area from Catalan parameters within the common cosolvency
    both practical and theoretical viewpoints. It is models for providing better predictions and
    involved in several pharmaceutical procedures like extending the applicability of the models to
    drug purification processes, drug identification, and include additional solute-solvent combinations.6
    homogenous pharmaceutical dosage forms design.1 Moreover, from solubility values and some
    Although solubility is a macroscopic property it is thermodynamic properties of the solvent mixture
    employed to analyze the respective molecular free of drug, the preferential solvation of several
    interactions involved in dissolution processes.2 drugs has been analyzed by means of the inverse
    Drug solubility defines the possible state of the Kirkwood-Buff integrals (IKBI) method. If the
    pharmaceutical dosage form under consideration. solubility increases constantly with the proportion
    This is of fundamental relevance if liquid solutions of cosolvent to reach the maximum in the neat
    are solicited. Moreover, it is generally observed cosolvent, the solute is preferentially solvated by
    that the more soluble drugs also exhibit higher water in water-rich mixtures but preferentially
    dissolution rates in the respective solvents.3 In this solvated by cosolvent in cosolvent-rich mixtures.
    way, the experimental determination and On the other hand, when the maximum solubility is
    correlation of the solubility of drugs in neat and obtained in a cosolvent-water mixture instead of
    mixed solvents has been a constantly increasing the neat cosolvent, the solute is preferentially
    research subject. Normally, the specific references solvated in water-rich and cosolvent-rich mixtures
    report the effect of temperature and/or mixtures but preferentially solvated by cosolvent in those
    composition on solubility. Temperature effect is mixtures of similar proportions of water and
    commonly evaluated by using several empirical or cosolvent.7 Finally, it is noteworthy the increasing
    semiempirical models like van’t Hoff, Apelblat, in the number of articles published in several
    Buchowski-Ksiazczak and Wilson. Mixtures journals around the world dealing with solubility
    composition effect is evaluated by means of and solution thermodynamics of drugs in neat and
    Yalkowsky-Roseman log-linear and the Nearly mixed solvents reveal that despite of various
    Ideal Binary Solvent/Redlich-Kister (NIBS/R-K) available solubility prediction methods reported in
    models as cosolvency prediction tools. the literature, one needs to rely on the experimental
    Furthermore, the combined effects of temperature determination of drug’s solubility and further
    and mixtures composition are analyzed by means improvements in the solubility prediction methods
    of the Jouyban-Acree model.4 Observed deviations is still required.8 Development of better predictive
    from predicted solubility values by some of these methods is greatly facilitated by accurate solubility
    models have been attributed to specific measurements using modern instrumentation and
    interactions. For instance, negative deviations to technology.
    Yalkowsky model in water-rich mixtures has been
    interpreted as the effect of hydrophobic hydration References
    around the non-polar groups of the solute, which 1. Jouyban A. Handbook of Solubility Data for
    reduce the solubility, whereas, the positive Pharmaceuticals. Boca Raton. FL: CRC Press;
    deviations observed in cosolvent-rich mixtures has 2010. p. 40-6.
    been considered as an effect of the solute solvation 2. Marcus Y. On the preferential solvation of
    by the cosolvent to obtain a less polar entity.5 A drugs and PAHs in binary solvent mixtures. J
    number of attempts were made to include some

    *Corresponding Author: Fleming Martínez, E-mail: fmartinezr@unal.edu.co


    ©2017 The Authors. This is an open access article and applies the Creative Commons Attribution (CC BY), which permits unrestricted use,
    distribution, and reproduction in any medium, as long as the original authors and source are cited. No permission is required from the authors
    or the publishers.
    Martínez et al.

    Mol Liq. 2008;140(1-3):61-7. J Chem Thermodyn. 2016;97:264-76.


    doi:10.1016/j.molliq.2008.01.005 doi:10.1016/j.jct.2016.02.002
    3. Martin A, Bustamante P, Chun AHC. Physical 6. Jouyban A, Soltanpour S, Soltani S, Tamizi E,
    Chemical Principles in the Pharmaceutical Fakhree MAA, Acree WE Jr. Prediction of drug
    Sciences. 4th ed. Philadelphia, PA: Lea & solubility in mixed solvents using computed
    Febiger; 1993. p. 212-43. Abraham parameters. J Mol Liq.
    4. Wang J, Xu A, Xu R. Solubility of 2-nitro-p- 2009;146(3):82-8.
    phenylenediamine in nine pure solvents and doi:10.1016/j.molliq.2009.02.003
    mixture of (methanol + N-methyl-2- 7. Delgado DR, Peña MÁ, Martínez F, Jouyban A,
    pyrrolidone) from T = (283.15 to 318.15) K: Acree WE Jr. Further numerical analyses on the
    Determination and modelling. J Chem solubility of sulfapyridine in ethanol + water
    Thermodyn. 2017;108:45-58. mixtures. Pharm Sci. 2016;22(3):143-52.
    doi:10.1016/j.jct.2017.01.006 doi:10.15171/PS.2016.24
    5. Delgado DR, Almanza OA, Martínez F, Peña 8. Jouyban A. Solubility; still a challenging
    MA, Jouyban A, Acree WE Jr. Solution subject in pharmaceutical sciences: An editorial.
    thermodynamics and preferential solvation of Vitae. 2010;17(3):241-2.
    sulfamethazine in (methanol + water) mixtures.

    2 | Pharmaceutical Sciences, March 2017, 23, 1-2

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