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Reference Materials Desirable Biological Variation Database specifications
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The 2014 edition of Desirable Specifications for imprecision, inaccuracy, and log in.
total allowable error,  calculated from data on within-subject and between-
 Username
subject biologic variation. This database was updated and compiled by Dr.
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Carmen Ricos and colleagues, before the EFLM took the helm. As of May 2019,
EFLM is managing the new biological variation database. We were honored to  Password
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and Bias, derived from intra- and inter-individual Forgot Login?
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westgard-683770/) Ricos C, Alvarez V, Cava F, Garcia-Lario JV, Hernandez A, Jimenez CV, Minchinela Sign up
J, Perich C, Simon M. "Current databases on biologic variation: pros, cons and (https://www.westgard.com/cb-
progress." Scand J Clin Lab Invest 1999;59:491-500. This database was last registration.html)
updated in 2014.
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(/biodatabase-2014-update.htm)
Other Articles
CALCULATORS 1999 Stockholm
PLEASE NOTE: The EFLM now hosts the latest database on Consensus
QC Tools biological variation! (https://biologicalvariation.eu/) Statement
(/qctools.htm) (/stockholm.htm)
2016 State of
QC Calculators Annex I, Part I: Within-subject and between-subject CV values of analytes and the Art
(/calculateqc.htm)
Desirable Analytical Quality Specifications for imprecision, bias and total error Hematology
Method Validation Performance
Tools 11-Desoxycortisol through a-Fetoprotein Specifications
(/mvtools.htm) Albumin through CA 549 antigen (/sota-2016-
Calcium through Cystine hematology.htm)
Six Sigma 2024 CLIA
Dehydroepiandrosterone sulfate through Hydroxlproline
Calculators (/six- Proposed
Immunoglobulin A through Lycopenene
sigma- Acceptance
Magnesium through Oxalate, output
calculators.htm) Limits for
pCO2 through Rheumatoid factor
Normalized SCC antigen through Zinc Proficiency
OPSpecs Testing (/2024-
Calculator clia-
requirements.htm) Privacy - Terms
(/normalized-
 opspecs- See The Reference List (/biodatabase3.htm) A selection of
calculator.htm) See The References (/biodatabase2.htm) SEKK-DMax
See The original Guest Essay (/guest17.htm) specifications
Quality Control (/sekk-
Grid Calculator
Note on abbreviations: dmax.htm)
(/qcsgtool.htm)
CVI = within-subject biologic variation Belgium EQA
Control Limit CVG = between-subject biologic variation performance
Calculator I = desirable specification for imprecision specifications
(/control-limit- B = desirable specification for inaccuracy (/belgium-eqa-
calculator.htm) TE = desirable specification for allowable total error goals.htm)
Biological
Reportable Range Variation
Calculator:   Database
Quantifying Errors reference list
(/reportable-range- Number Biological Desirable (/biodatabase3.htm)
calculator-br- Variation specification Biological
Analyte of
quantifying- Variation
Papers CVI CVg I(%) B(%) TE(%)
errors.htm) Database
S- 11-Desoxycortisol 2 21.3 31.5 10.7 9.5 27.1 references
Reportable Range
S- 17-Hydroxyprogesterone 2 19.6 50.4 9.8 13.5 29.7 (/biodatabase2.htm)
Calculator:
4-hydroxy-3-methoximandelate Biological
Recording Results U- 1 22.2 47.0 11.1 13.0 31.3
(VMA) Variation in
(/reportable-range-
Patients with
calculator-br- S- 5' Nucleotidase 2 23.2 19.9 11.6 7.6 26.8
Disease
recording- 5'-Hydroxyindolacetate,
U- 1 20.3 33.2 10.2 9.7 26.5 (/biodatabasedisease.htm)
results.htm) concentration CLIA
Dispersion S- α1-Acid Glycoprotein 3 11.3 24.9 5.7 6.8 16.2 Requirements
Calculator and S- α1-Antichymotrypsin 1 13.5 18.3 6.8 5.7 16.8 for Analytical
Critical Number of Quality
S- α1-Antitrypsin 3 5.9 16.3 3.0 4.3 9.2
Test Samples (/clia.htm)
S- α1-Globulins 2 11.4 22.6 5.7 6.3 15.7 Clinical Quality
(/dispersion-
calculator-and- α1-Microglobulin, concentration, Requirements
U- 1 33.0 58.0 16.5 16.7 43.9
critical-number-of- first morning (/clinical.htm)
test-samples.htm) P- α2-Antiplasmin 1 6.2 --- 3.1 --- --- Consolidated
Comparison of
S- α2-Globulins 2 10.3 12.7 5.2 4.1 12.6
Chemistry
ONLINE STORE S- α2-Macroglobulin 4 3.4 18.7 1.7 4.75 7.56 Performance
α2-Microglobulin output, first Specifications
U- 1 29.0 32.0 14.5 10.8 34.7
morning (/consolidated-
P- α-aminobutryic acid 1 24.7 32.3 12.4 10.2 30.5 goals-
chemistry.htm)
S- α-Amylase 7 8.7 28.3 4.4 7.4 14.6
Consolidated
(/store/books-and- S- α-Amylase (pancreatic) 2 11.7 29.9 5.9 8.0 17.7 Comparison of
reference-manuals/the- U- α-Amylase (pancreatic) 2 69.5 105.0 34.75 31.48 88.82 Hematology
poor-labs-guide- Performance
U- α-Amylase concentration, random 1 94.0 46.0 47.0 26.2 103.7
detail.html) Specifications
The Poor Lab's Guide P- α-Carotene 1 24.0 65.0 12.0 17.3 37.1
(/hematology-
2021 (/store/books-and- S- α-Carotene 1 48.0 65.0 24.0 20.2 59.8 goals.htm)
reference-manuals/the- α-Fetoprotein(non hepatic Consolidated
poor-labs-guide- S- 2 12.2 45.6 6.1 11.8 21.9
carcinoma) Comparison of
detail.html) Immunoassay
S- α-Tocopherol 3 13.8 15.0 6.9 5.1 16.5
$80.00 Performance
S- Acid phosphatase 2 8.9 8.0 4.5 3.0 10.3
Specifications
Acid phosphatase tartrate- (/consolidated-
S- 2 8.0 13.3 4.0 3.9 10.5
resistant (TR-ACP) goals-
(/store/online- Acid phosphatase prostatic immunoassay.htm)
S- 1 33.8 --- 16.9 --- ---
training/basic-method- activity (PAP) Consolidated
validation-online- Activated partial thromboplastine measurement
P- 3 2.7 8.6 1.4 2.3 4.5 uncertainty
course-detail.html) time
Basic Method Validation specifications
P- Adiponectin 1 18.8 51.2 9.4 13.6 29.1
Online Course (/consolidated-
S- Adenosine deaminase (ADA) 1 11.7 25.5 5.9 7.0 16.7 uncertainty.htm)
(/store/online-
training/basic-method- P- Alanine 1 14.7 55.8 7.4 14.4 26.6 Desirable
validation-online- S- Alanine aminopeptidase 1 4.1 --- 2.1 --- --- Biological
course-detail.html) Variation
S- Alanine aminotransferase (ALT) 9 19.40 41.6 9.7 11.48 27.48
$175.00 Database
specifications
Back to top
(/biodatabase1.htm)
PHOTO GALLERY
European
Number Biological Desirable Biologic Goals
Analyte of Variation specification (/europe.htm)
papers CVI CVg I(%) B(%) TE(%) Final Milan
S- Albumin 24 3.2 4.75 1.6 1.43 4.07 Hierarchy
(/milan-
Albumin, concentration, first
U- 3 36.0 55.0 18.0 16.4 46.1 mandate.htm)
morning
French EQA
U- Albumin, output, night urine 3 29.5 58.0 14.8 16.3 40.6 performance
S- Albumin, glycated 1 5.2 10.3 2.6 2.9 7.2 specifications
(/french-eqa-
S- Aldosterone 2 29.4 40.1 14.7 12.4 36.7
goals.htm)
U- Aldosterone 1 39.4 40.1 19.7 14.05 46.56
Milan 2014
S- Alkaline phosphatase 22 6.45 26.1 3.23 6.72 12.04 Consensus
S- Alkaline phosphatase, bone 4 6.2 37.4 3.1 9.5 14.6 Draft on Quality
Specifications
S- Alkaline phosphatase, liver 1 10.0 27.0 5.0 7.2 15.4
(/milan-2014-
S- Alkaline phosphatase, placental 1 19.1 --- 9.6 --- ---
draft1.htm)
U- Ammonia, output, 24h 1 24.7 27.3 12.4 9.2 29.6 Minimum
S- Amyloid A 1 25.0 61.0 12.5 16.5 37.1 analytical
quality
S- Androstendione 2 15.8 38.8 7.9 10.47 23.51
requirements
S- Anion gap   9.5 10.1 4.8 3.5 11.3 (/minimum-
P- Antithrombin III 4 5.2 15.3 2.6 4.0 8.3 requirements.htm)
S- Apolipoprotein A1 11 6.5 13.4 3.3 3.7 9.1 Minimum
Specifications
S- Apolipoprotein B 9 6.9 22.8 3.5 6.0 11.6
from Biological
P- Arginine 1 19.3 34.1 9.7 9.8 25.7 Variation
Arilestearase activity, non database
S- 1 3.8 37.2 1.9 9.3 12.5
inhibited (/minimum-
P- Ascorbate (Vitamin C) 1 20.0 21.0 10.0 7.3 23.8 biodatabase1.htm)
New Goals for
S- Ascorbate (Vitamin C) 3 26.0 31.0 13.0 10.1 31.6
MU Goals (/mu-
P- Asparagine 1 12.3 28.0 6.2 7.6 17.8 performance-
Aspartate aminotransferase specifications.htm)
S- 13 12.3 23.1 6.15 6.54 16.69
(AST) Optimal
P- Aspartic acid 1 31.2 55.1 15.6 15.8 41.6 Biological
Variation
S- β-2-Microglobulin 1 5.9 15.5 3.0 4.1 9.0
database
P- β-Carotene 1 18.0 48.0 9.0 12.8 27.7
specifications
S- β-Carotene 4 36.0 39.7 18.0 13.4 43.1 (/optimal-
S- β-Cryptoxantin 1 36.7 --- 18.4 --- --- biodatabase1htm.htm)
Quality
S- β-Globulins 2 10.1 9.1 5.1 3.4 11.7
Requirements
B- Base excess 1 76.4 43.2 38.2 21.9 85.0 for Dogs, Cats,
B- Basophile, count 3 28.0 54.8 14.0 15.4 38.5 and Horses?
S- Bilirubin total 11 21.8 28.4 10.90 8.95 26.94 (/quality-
requirements-
S- Bilirubin conjugated 2 36.8 43.2 18.4 14.2 44.5
for-dogs-cats-
P- C Protein 1 5.6 55.2 2.9 13.9 18.7 and-
S- C reactive protein 3 42.2 76.3 21.1 21.8 56.6 horses.htm)
C reactive protein - high RCPA Allowable
S- 1 49.70 89.23 24.85 25.53 66.54 Limits of
sensitivity
Performance for
S- C3 Complement 2 5.2 15.6 2.6 4.1 8.4
Biochemistry
S- C4 Complement 2 8.9 33.4 4.5 8.6 16.0 (/rcpa-
S- CA 125 antigen 4 24.7 54.6 12.4 15.0 35.4 biochemistry.htm)
S- CA 15.3 antigen 5 6.1 62.9 3.1 15.8 20.8 Rilibak -
German
S- CA 19.9 antigen 2 16.0 130.5 7.98 32.87 46.03
Guidelines for
S- CA 549 antigen 1 9.1 33.4 4.6 8.7 16.2 Quality
(/rilibak.htm)
Back to top Spanish
Minimum
Number Biological Desirable Consensus
Analyte of Variation specification Performance
papers CVI CVg I(%) B(%) TE(%) Specifications
(/minimum-
S- Calcium 24 2.1 2.5 1.05 0.82 2.55
consensus-
S- Calcium, complexed 1 5.3 4.5 2.7 1.7 6.1 specifications.htm)
U- Calcium, concentration, 24h 4 27.5 36.6 13.8 11.4 34.1 The New Era of
S- Calcium, ionized 2 1.7 1.9 0.9 0.6 2.0 Biological
Variation:
S- Calcium, protein bound 1 4.1 6.1 2.1 1.8 5.2
EUBIVAS
S- Calcium, ultrafiltrable 1 2.2 2.7 1.1 0.9 2.7 (/eubivas.htm)
Carbohydrate deficient
S- 1 7.1 38.7 3.6 9.8 15.7
transferrin
 search...
B- CO2, total 1 4.0 4.8 2.0 1.56 4.86
Carcinoembryonic antigen
S- 10 12.7 55.6 6.4 14.3 24.7
(CEA)
What's New
S- Carnitine, Acyl-free 1 11.35 24.3 5.68 6.71 16.07
13 of 17 assays on a
S- Carnitine, free 1 8.05 16.65 4.03 4.62 11.26
Roche Cobas 6000
S- Carnitine, total 1 8.85 11.80 4.43 3.69 10.99 c501 cannot hit
S- Ceruloplasmin (ferroxidase) 2 5.8 11.1 2.9 3.1 7.9 preferred
measurement
S- Chloride 19 1.2 1.5 0.6 0.5 1.5 uncertainty goals
(/mu-roche-cobas-
S- Cholesterol 46 5.95 15.3 2.98 4.1 9.01
6000-turkey.htm)
S- Cholinesterase, concentration 2 7.1 --- 3.6 --- ---
ADVIA 2120i in
S- Cholinesterase, activity 3 6.1 18.2 3.1 4.8 9.8
Croatia, Multimode
P- Chromogranin A 1 12.8 26.3 6.4 7.3 17.9
Analysis (/multimode-
P- Citrulline 1 21.4 43.9 10.7 12.2 29.9 advia-2120-
Collagen type I C propeptide croatia.htm)
S- 3 7.8 26.7 3.9 7.0 13.4
(PICP)
This is How you QC
Collagen type I N propeptide (/this-is-how-you-
S- 3 7.4 57.3 3.7 14.4 20.5
(PINP) qc.htm)
Collagen type III N propeptide
S- 1 13.6 87.2 6.8 22.1 33.3 Mindray BC 7500 in
(PIIINP)
China, multimode
U- Color, first morning 1 30.9 47.4 15.5 14.1 39.6 analysis (/multimode-
P- Copper 3 8.0 19.0 4.0 5.2 11.8 mindray-bc-7500-
S- Copper 2 4.7 13.6 2.35 3.6 7.47 china.htm)

P- Cortisol 1 21.7 46.2 10.85 12.76 30.66 Sysmex XN 350 in

S- Cortisol 3 15.2 38.1 7.6 10.26 22.8 India, multimode
analysis (/multimode-
S- C Peptide 3 16.6 23.2 8.3 7.1 20.8
sysmex-xn-350-
S- Creatine kinase (CK) 9 22.8 40.0 11.4 11.5 30.3 india.htm)
S- Creatine kinase MB, % 1 6.9 48.2 3.5 10.8 16.5
S- Creatine kinase MB, activity 4 19.7 24.3 9.9 7.8 24.1
 
S- Creatine kinase MB, mass 1 18.4 61.2 9.2 14.88 30.06
S- Creatinine 28 5.95 14.7 2.98 3.96 8.87
U- Creatinine, concentration, 24h 8 24.0 24.5 12.0 8.6 28.4
Creatinine, concentration, first
U- 8 23.2 25.7 11.6 8.7 27.8
morning
Creatinine, concentration,
U- 8 36.3 32.4 18.2 12.2 42.1
random
U- Creatinine, output, 24h 8 11.0 23.0 5.5 6.4 15.4
 
C-Terminal telopeptide type I
S- 5 10.85 30.6 5.43 8.12 15.45
collagen (CTY I)
S- Cyfra 21.1 Antigen 2 22.2 31.1 11.1 9.6 27.9
P- Cystatin C 1 5.5 --- 2.8 --- ---
S- Cystatin C 4 5.0 13.0 2.5 3.48 7.61
P- Cysteine 1 5.9 12.3 3.0 3.4 8.3
P- Cystine 1 38.3 48.5 19.2 15.4 47.0

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Number Biological Desirable

Analyte of Variation specification
Papers CVI CVg I(%) B(%) TE(%)
S- D-Dimer (MoM) 1 23.3 26.5 11.65 8.82 28.04
Dehydroepiandrosterone
S- 3 6.35 30.70 3.188 7.84 13.08
sulfate (DHEAS)
Deoxypyridinoline/creatinine,
U- 2 16.0 30.7 8.0 8.7 21.9
24h
Deoxypyridinoline/creatinine,
U- 2 13.8 34.6 6.9 9.3 20.7
first morning
Deoxipyridinoline/minute, first
U- 2 15.4 30.3 7.7 8.5 21.2
morning
P- Dipeptidyl-peptidase IV (ACE) 2 8.2 14.5 4.1 4.2 10.9
S- Dipeptidyl-peptidase IV (ACE) 1 12.5 27.7 6.3 7.6 17.9
P- Elastase 1 12.4 15.1 6.2 4.88 15.11
B- Eosinophils, count 3 21.0 76.4 10.5 19.8 37.1
(B)Plat- Epinephrine 1 25.3 --- 12.7 --- ---
P- Epinephrine 1 48.3 --- 24.2 --- ---
B- Erythrocytes, count 7 3.2 6.3 1.6 1.7 4.4
B- Erythrocyte distribution wide   3.5 5.7 1.8 1.7 4.6
U- Estradiol 1 30.4 --- 15.2 --- ---
S- Estradiol 5 22.5 24.4 11.25 8.3 26.86
S- Estradiol, free 1 22.8 --- 11.40 --- ---
U- Estradiol, free 1 38.6 --- 19.3 --- ---
P- Factor V coagulation 1 3.6 --- 1.8 --- ---
P- Factor VII coagulation 2 6.8 19.4 3.4 5.1 10.7
P- Factor VIII coagulation 2 4.8 19.1 2.4 4.9 8.9
P- Factor X coagulation 1 5.9 --- 3.0 --- ---
S- Ferritin 6 14.2 15.0 7.1 5.2 16.9
P- Fibrinogen 5 10.7 15.8 5.4 4.8 13.6
(B)Erthry- Folate 1 12.0 66.0 6.0 16.8 26.7
S- Folate 1 24.0 73.0 12.0 19.2 39.0
Follicle stimulating hormone
S- 5 11.0 47.2 5.5 12.12 21.19
(FSH)
S- Fructosamine 3 3.4 5.9 1.7 1.7 4.5
S- Galactosyl hydroxylysine 1 11.8 25.8 5.9 7.1 16.8
P- γ-Fibrinogen 1 14.1 27.25 7.05 7.67 19.3
S- γ-Globulins 2 14.6 12.3 7.3 4.8 16.8
S- γ-glutamyltransferase (GGT) 10 13.4 42.15 6.7 11.06 22.11
S- Globulins, total 1 5.5 12.9 2.8 3.5 8.0
P- Glucose 1 4.5 5.8 2.3 1.8 5.5
S- Glucose 15 5.6 7.5 2.8 2.34 6.96
Glucose-6-phosphate-1-
(B)Erythr- 1 32.8 31.8 16.4 11.4 38.5
dehydrogenase (G6PDH)
Glucose-6-phosphate-1-
B - spot 1 7.3 10.3 3.7 3.2 9.2
dehydrogenase (G6PDH)
P- Glutamic acid 1 46.4 79.9 23.2 23.1 61.4
P- Glutamine 1 12.1 22.0 6.1 6.3 16.3
S- Glutathion peroxidase 1 7.2 21.7 3.6 5.7 11.7
P- Glycine 1 11.8 40.3 5.9 10.5 20.2
P- Haptoglobin 1 20.0 27.9 10.0 8.6 25.1
S- Haptoglobin 3 20.4 36.4 10.2 10.4 27.3
S- HDL cholesterol 25 7.3 21.2 3.65 5.61 11.63
S- HDL 1 cholesterol 1 5.5 27.2 2.8 6.9 11.5
S- HDL 2 cholesterol 6 15.7 40.7 7.9 10.9 23.9
S- HDL 3 cholesterol 6 7.0 14.3 3.5 4.0 9.8
B- Hematocrit 11 2.7 6.41 1.35 1.74 3.97
B- Hemoglobin 13 2.85 6.8 1.43 1.84 4.19
B- Hemoglobin A1 C 8 1.9 5.7 0.9 1.5 3.0
B- Hemoglobin A2 1 0.7 7.7 0.35 1.93 2.51
P- Histidine 1 9.7 27.2 4.9 7.2 15.2
P- Homocysteine 3 8.3 33.5 4.15 8.63 15.48
S- Hyaluronic acid 1 62.00 --- 31.00 --- ---
Hydroxybutyrate
S- 1 6.6 --- 3.3 --- ---
dehydrogenase
P- Hydroxyproline 1 34.5 56.7 17.3 16.6 45.1
Hydroxyproline/minute, first
U- 1 36.1 38.8 18.1 13.2 43.0
morning
Hydroxyproline/minute,
U- 1 40.5 32.9 20.3 13.0 46.5
second void

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Biological Desirable
Number of
Analyte Variation specification
papers
CVI CVg I(%) B(%) TE(%)
S- Immunoglobulin A 7 5.4 35.9 2.7 9.1 13.5
S- Immunoglobulin G 6 4.5 16.5 2.3 4.3 8.0
S- Immunoglobulin M 5 5.9 47.3 3.0 11.9 16.8
S- Immunoglobulins κ chains 3 4.8 15.3 2.4 4.0 8.0
S- Immunoglobulins λ chains 3 4.8 18.0 2.4 4.7 8.6
S- Inhibin B 1 10.0 25.0 5 6.73 14.98
S- Insulin 4 21.1 58.3 10.6 15.5 32.9
Insulin-like growth factor
S- 2 14.6 45.4 7.3 11.9 24.0
(IGF-1)
Insulin-like growth factor
S- 1 10.1 63.9 5.1 16.2 24.5
binding protein 3 (IGFBP-3)
Intercellular adhesion
S- 1 1.9 21.0 1.0 5.3 6.8
molecule-1 (ICAM-1)
(B)Leuc- Interferon receptor 1 14.0 20.0 7.0 6.1 17.7
S- Interleukin 1-β 1 30.0 36.0 15.0 11.7 36.5
S- Interleukin-8 1 24.0 31.0 12.0 9.8 29.6
S- Iron 11 26.5 23.2 13.3 8.8 30.7
P- Isoleucine 1 15.5 45.5 7.8 12.0 24.8
S- Kallicrein 6 1 11.80 27.6 5.9 7.5 17.24
B- Lactate 1 27.2 16.7 13.6 8.0 30.4
Lactate dehydrogenase
S- 11 8.6 14.7 4.3 4.3 11.4
(LDH)
Lactate dehydrogenase 1
S- 2 2.3 8.3 1.2 2.2 4.1
isoform (LDH1)
Lactate dehydrogenase 2
S- 1 3.3 2.4 1.7 1.0 3.7
isoform (LDH2)
Lactate dehydrogenase 3
S- 1 2.8 3.8 1.4 1.2 3.5
isoform (LDH3)
Lactate dehydrogenase 4
S- 1 5.9 5.3 3.0 2.0 6.9
isoform (LDH4)
Lactate dehydrogenase 5
S- 1 8.0 9.6 4.0 3.1 9.7
isoform (LDH5)
P- Lactoferrin 1 11.8 23.7 5.9 6.6 16.4
S- LDL Cholesterol 6 7.8 20.4 3.9 5.46 11.9
P- LDL Cholesterol (oxidized) 1 21.0 50.0 10.5 13.6 30.9
LDL Cholesterol, small
S- 1 9.1 20.0 4.55 5.49 13.0
dense
S- LDL receptor mRNA 1 21.5 13.6 10.8 6.4 24.1
P- Leucine 1 14.8 44.0 7.4 11.6 23.8
B- Leukocytes count 8 11.4 21.3 5.73 6.05 15.49
S- Lipase 3 32.2 31.8 16.1 11.31 37.88
S- Lipoprotein (a) 3 20.8 18.1 10.4 6.9 24.1
P- Lutein 1 13.0 21.0 6.5 6.2 16.9
S- Lutein 1 23.7 --- 11.9 --- ---
S- Luteinizing hormone (LH) 5 23.0 27.4 11.5 8.94 27.92
P- Lycopene 1 22.0 33.0 11.0 9.9 28.1
S- Lycopene 2 40.1 33.0 20.1 13.0 ---
B- Lymphocytes, count 1 10.2 35.3 5.1 9.19 17.6
B- Lymphocytes CD4 5 25.0 --- 12.5 --- ---
P- Lysine 1 11.5 38.2 5.8 10.0 19.5

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Number Biological Desirable

Analyte of Variation specification
Papers CVI CVg I(%) B(%) TE(%)
(B)Erythr- Magnesium 2 5.6 11.3 2.8 3.2 7.8
(B)Leuc- Magnesium 1 18.5 12.4 9.25 5.57 20.83
(B)Mon - Magnesium 1 18.1 20.3 9.1 6.8 21.7
S- Magnesium 9 3.6 6.4 1.8 1.8 4.8
U- Magnesium, ionized 1 1.9 5.1 1.0 1.4 2.9
U- Magnesium, output, 24h 2 38.3 37.6 19.2 13.4 45.0
Mean corpuscular hemoglobin
(B)Erythr- 4 1.4 5.2 0.7 1.35 2.5
(MCH)
Mean corpuscular hemoglobin
(B)Erythr- 5 1.06 1.2 0.53 0.4 1.27
concentration (MCHC)
Mean corpuscular volume
(B)Erythr- 7 1.4 4.85 0.7 1.26 2.42
(MCV)
(B)Plat- Mean platelet volume (MPV) 3 4.3 8.1 2.15 2.29 5.84
P- Metionine 1 14.7 43.4 7.4 11.5 23.6
B- Monocytes, count 3 17.8 49.8 8.9 13.2 27.9
S- Myeloperoxidase 1 36.0 30.0 18.0 11.7 41.4
S- Myoglobin 2 13.9 29.6 7.0 8.2 19.6
N-Acetyl Glucosaminidase,
U- 2 52.9 22.0 26.5 14.3 58.0
concentration, first morning
N-Acetyl
U- 2 51.1 21.8 25.6 13.9 56.0
Glucosaminidase/Creatinine
B- Neutrophyles, count 5 17.1 32.8 8.55 9.25 23.35
U- Nitrogen, output 1 13.9 24.2 7.0 7.0 18.4
B(Plat)- Norepinephrine 1 9.5 --- 4.8 --- ---
P- Norepinephrine 1 19.5 --- 9.8 --- ---
U- N-Telopeptide type I collagen 3 15.5 37.6 7.75 10.17 22.95
S- N-terminal (NT)-proBNP 2 10.0 16.0 5.0 4.7 13.0
P- Ornithine 1 18.4 54.9 9.2 14.5 29.7
P- Osmolality 1 1.3 1.5 0.7 0.5 1.6
Saliva- Osmolality 1 9.5 35.8 4.8 9.3 17.1
S- Osmolality 1 1.3 1.2 0.7 0.4 1.5
U- Osmolality, first morning 1 28.3 57.9 14.2 16.1 39.5
S- Osteocalcin 5 6.35 30.9 3.18 7.89 13.13
U- Oxalate, concentration, 24h 1 44.0 18.0 22.0 11.9 48.2
U- Oxalate, output, 24h 1 42.5 19.9 21.3 11.7 46.8

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Number Biological Desirable

Analyte
of Variation specification
papers CVI CVg I(%) B(%) TE(%)
B- pCO2 1 4.8 5.3 2.4 1.8 5.7
B- pH [H+] 1 3.5 2.0 1.8 1.0 3.9
B- pH (pH units) 1 0.2 --- 0.1 --- ---
S- Paraoxonase 1 1 13.4 84.0 6.7 21.3 32.3
Paraoxonase 1 substrate
S- 1 3.9 80.1 1.9 20.0 23.2
inhibition (PON 4SI)
Paraoxonase, activity (salt
S- 1 8.0 86.4 4.0 21.7 28.3
stimulated)
P- Parathyroid hormone (PTH) 1 25.3 43.4 12.65 12.56 33.43
S- Parathyroid hormone (PTH) 1 25.9 23.8 13.0 8.8 30.2
S- Phenylacetate 1 6.6 25.2 3.3 6.5 12.0
P- Phenylalanine 1 9.5 40.6 4.8 10.4 18.3
S- Phosphate 17 8.15 10.8 4.08 3.38 10.11
U- Phosphate, output, 24h 5 18.0 22.6 9.0 7.2 22.1
Phosphate tubular
Patient- 1 2.7 3.3 1.4 1.1 3.3
reabsorption
S- Phospholipids 1 6.5 11.1 3.3 3.2 8.6
P- Plasminogen 1 7.7 --- 3.9 --- ---
B- Platelets, count 7 9.1 21.9 4.6 5.9 13.4
B- Platelet distribution wide 2 2.8 --- 1.4 --- ---
B- Plateletcrit 2 11.9 --- 6.0 --- ---
U- Porphobilinogen 1 17.0 31.0 8.5 8.8 22.9
U- Porphyrins (total) 1 40.0 --- 20.0 --- ---
(B)Leuc- Potassium 1 13.6 13.4 6.8 4.8 16.0
S- Potassium 20 4.6 5.6 2.3 1.81 5.61
U- Potassium, output 4 24.4 22.2 12.2 8.2 28.4
S- Prealbumin 1 10.9 19.1 5.5 5.5 14.5
Pregnancy-associated
S- 1 12.6 14.0 6.3 4.71 15.1
plasma protein A (PAPP-A)
P- Prolactin 1 39.2 65.1 19.6 19.0 51.34
S- Prolactin 4 23.0 35.0 11.5 10.5 29.4
P- Proline 1 17.0 104.4 8.5 26.4 40.5
P- Prolyl endopeptidase 2 16.8 13.9 8.4 5.5 19.3
S- Properdin factor B 1 9.5 11.2 4.7 3.7 11.5
Prostatic specific antigen
S- 3 18.1 72.4 9.1 18.7 33.6
(PSA)
S- Protein 18 2.75 4.7 1.38 1.36 3.63
S- Protein, glycated 1 0.9 11.6 0.5 2.9 3.7
U- Protein, output, 24h 2 35.5 23.7 17.8 10.7 40.0
P- Prothrombin time 2 4.0 6.8 2.0 2.0 5.3
U- Pyridinoline 1 19.4 23.6 9.7 7.6 23.6
B- Pyruvate 1 15.2 13.0 7.6 5.0 17.5
Receptor for advanced
S- glycation end-products 1 14.6 56.5 7.3 14.59 26.63
(RAGE)
 Red cell distribution wide
B- 4 3.5 5.7 1.8 1.7 4.6
(RDW)
Reticulocyte highly
B- 1 10.0 62.0 5.0 15.7 24.0
fluorescent, count
Reticulocyte low fluorescent,
B- 1 1.6 4.9 0.8 1.3 2.6
count
Reticulocyte medium
B- 1 13.0 33.0 6.5 8.9 19.6
fluorescent, count
B- Reticulocyte, count 1 11.0 29.0 5.5 7.8 16.8
P- Retinol 1 6.2 21.0 3.1 5.5 10.6
S- Retinol 2 13.6 19.0 6.8 5.8 17.1
S- Rheumatoid factor 1 8.5 24.5 4.3 6.5 13.5

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<

Number Biological Desirable

Analyte of Variation specification
papers CVI CVg I(%) B(%) TE(%)
S- SCC antigen 1 39.4 35.7 19.7 13.3 45.8
P- S Protein 1 5.8 63.4 2.9 15.9 20.7
P- Selenium 1 12.0 14.0 6.0 4.6 14.5
B- Selenium 1 12.0 12.0 6.0 4.2 14.1
P- Serine 1 12.8 42.8 6.4 11.2 21.7
Sex hormone binding
S- 2 13.05 36.35 6.53 9.66 20.42
globulin (SHBG)
(B)Erythr- Sodium 1 1.8 12.4 0.9 3.1 4.6
(B)Leuc- Sodium 1 51.0 36.4 25.5 15.7 57.7
S- Sodium 21 0.6 0.7 0.3 0.23 0.73
B- Sodium Bicarbonate 1 4.0 4.8 2.0 1.6 4.9
S- Sodium Bicarbonate 7 4.8 4.7 2.4 1.7 5.6
Sweat- Sodium Chloride 1 15.0 25.0 7.5 7.3 19.7
U- Sodium, output, 24 h. 4 28.7 16.7 14.4 8.3 32.0
P- Soluble CD163 1 9.0 35.9 4.5 9.3 16.7
U- Specific gravity 1 0.4 1.0 0.2 0.27 0.60
Spermatozoa,
Semen- 1 26.8 56.4 13.4 15.6 37.7
concentration
Semen- Spermatozoa, morphology 1 19.6 44.0 9.8 12.0 28.2
Spermatozoa, progressive
Semen- 1 15.2 32.8 7.6 9.0 21.6
motility
Spermatozoa, fast
Semen- 1 18.8 51.8 9.4 13.8 29.3
progressive motility
Semen- Spermatozoa, total motility 1 18.4 29.8 9.2 8.8 23.9
Semen- Spermatozoa, vitality 1 10.3 25.8 5.2 6.9 15.4
S- Superoxide dismutase 1 17.1 10.5 8.6 5.0 19.1
(B)Erythr- Superoxide dismutase 1 12.3 4.9 6.2 3.3 13.5
P- Taurine 1 30.6 44.0 15.3 13.4 38.6
P- Testosterone 1 12.6 40.80 6.3 10.68 21.07
S- Testosterone 7 9.25 22.05 4.63 5.98 13.61
Saliva- Testosterone 1 17.3 28.8 8.7 8.4 22.7
U- Testosterone 1 25.0 --- 12.5 --- ---
S- Testosterone, free 3 9.3 --- 4.7 --- ---
U- Testosterone, free 1 51.7 --- 25.9 --- ---
S- Thyroglobulin 2 14.0 39.0 7.0 10.4 21.9
S- Thyroglobulin antibody 1 8.5 82.0 4.3 20.6 27.6
Thyroid peroxidase
S- 1 11.3 147.0 5.7 36.9 46.2
antibody
Thyroid stimulating
P- 1 29.30 48.4 14.65 14.14 38.2
hormone (TSH)
Thyroid stimulating
S- 9 19.3 24.6 9.7 7.8 23.7
hormone (TSH)
Thyrotropin receptor
S- 1 4.8 --- 2.4 --- ---
antibody
S- Thyroxine (T4) 11 4.9 10.9 2.5 3.0 7.0
P- Thyroxine, free (FT4) 1 7.1 9.1 3.55 2.89 8.74
S- Thyroxine, free (FT4) 5 5.7 12.1 2.9 3.3 8.0
Thyroxine binding globulin
S- 2 0.09 0.06 0.0 0.0 0.1
(TBG)
P- Tirosine 1 10.5 61.0 5.3 15.5 24.1
Tissue polypeptide antigen
S- 1 31.1 63.7 15.6 17.7 43.4
(TPA)
Tissue polypeptide specific
S- 1 36.1 108.0 18.1 28.5 58.3
antigen (TPS)
Total catecolamines,
U- 1 24.0 32.0 12.0 10.0 29.8
concentration, 24h
S- Transferrin 5 3.0 4.3 1.5 1.3 3.8
P- Treonine 1 17.9 33.1 9.0 9.4 24.2
S- Triglyceride 31 19.9 32.7 9.95 9.57 25.99
P- Triiodothyronine (T3) 1 9.4 18.5 4.7 5.19 12.94
S- Triiodothyronine (T3) 10 6.9 12.3 3.45 3.53 9.22
S- Triiodothyronine, free (FT3) 4 7.9 17.6 4.0 4.8 11.3
P- Troponin I 1 37.1 179.2 18.55 45.75 76.36
S- Troponin I 5 14.05 63.75 7.03 16.32 27.91
S- Troponin T 1 30.5 90.0 15.3 23.7 48.9
P- Tryptophan 1 22.7 152.6 11.4 38.6 57.3
Tumor Necrosis Factor-a
S- 1 43.0 29.0 21.5 13.0 48.4
(TNF-a)
S- Urate 16 8.6 17.5 4.3 4.87 11.97
U- Urate, output, 24h 2 16.8 14.4 8.4 5.53 19.39
S- Urea 20 12.1 18.7 6.05 5.57 15.55
U- Urea, output, 24h 4 17.4 25.4 8.7 7.7 22.1
P- Valine 1 10.6 40.1 5.3 10.4 19.1
Vanilmandelic Acid
U- 1 22.2 47.0 11.1 13.0 31.3
concentration, 24h
Vascular cell adhesion
S- 1 5.2 16.0 2.6 4.2 8.5
molecule-1 (VCAM-1)
Vascular endotelial growth
P- 1 14.1 18.1 7.1 5.7 17.4
factor
Vascular endotelial growth
B- 1 14.3 28.8 7.2 8.0 19.8
factor
Vascular endotelial growth
S- 1 10.7 47.6 5.4 12.2 21.0
factor
P- Vitamin B1 1 4.8 12.0 2.4 3.2 7.2
B- Vitamin B2 (Riboflavin) 1 5.8 10.0 2.9 2.9 7.7
(B)Eryth- Vitamin B2 (Riboflavin) 1 6.4 11.0 3.2 3.2 8.5
Vitamin B2 status
(B)Eryth- (gluthation reductase 1 5.2 40.0 2.6 10.1 14.4
activation)
(B)Eryth- Vitamin B12 1 15.0 69.0 7.5 17.7 30.0
(B)Eryth- Vitamin B6 1 14.0 24.0 7.0 6.9 18.5
B- Vitamin B6 1 20.0 34.0 10.0 9.9 26.4
(B)Eryth- Vitamin E (Tocopherol) 1 7.6 21.0 3.8 5.6 11.9
(B)Eryth- Vitamin K (Phylloquinone) 1 38.0 44.0 19.0 14.5 45.9
S- VLDL Cholesterol 2 27.6 --- 13.8 --- ---
P- Von Willebrand factor 3 2.5 27.3 1.3 6.9 8.9
S- Water 1 3.1 0.1 1.6 0.8 3.3
S- Zeaxanthine 1 34.7 --- 17.4 --- ---
S- Zinc 1 9.3 9.4 4.7 3.3 11.0
P- Zinc 3 11.0 14.0 5.5 4.5 13.5

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