No Author, Year Country Study Design Total LRH ARH Mean Age Histology Stage

Population Population Population

1 Anchora, 2020 Italy RCT 423 206 217 46 SCC and IA, IB, IIA
Others
2 Chen, 2020 China Cohort 1982 513 1469 52.4 SCC IIA
Retrospective
3 Chen X, 2020 China Cohort 325 129 196 50.7 SCC, ACC, ASC IB1
Retrospective
4 Choi, 2012 Korea Cohort 338 194 144 46.5 SCC, ACC, ASC IA1, IA2, IB1,
Retrospective IIA
5 Corrado, 2018 Italy Cohort 341 240 101 47 SCC, ACC, ASC, IB1
Retrospective Glass Cell
6 Ditto, 2014 Italy Cohort 120 60 60 45 SCC and IA2
Retrospective Others
7 Gil-Moreno, 2018 Spain Cohort 188 112 76 48.2 SCC, ACC IB1. IIA1
Retrospective
8 Guo, 2018 China Cohort 551 412 139 42 SCC and Non- IA, IB, IIA
Retrospective SCC
9 Hans, 2020 Netherland Cohort 1109 369 740 45 SCC, ACC, ASC IA2, IB1, IIA1
Retrospective
10 He, 2020 China Cohort 4821 1634 3187 46 SCC, ACC, ASC IA1, IA2
Retrospective
11 Hu, 2019 China Cohort 678 255 423 42 SCC, ACC, ASC IA2, IB, IIA
Retrospective
12 Kim, 2019 Korea Cohort 724 222 342 49 SCC, ACC, ASC IB1, IB2
Retrospective
13 Kongo, 2014 Korea Cohort 88 40 48 46 SCC, ACC, ASC IB1, IB2, IIA
Retrospective
14 Lande, 2012 Netherland Cohort 156 63 93 NA SCC, ACC, IB1, IB2
Retrospective Mixed
15 Li, 2020 Korea Cohort 562 280 282 47.5 SCC, ACC, ASC, IA1, IB1, IB2,
Retrospective Others IIA
16 Lim, 2022 Singapore Cohort 136 51 85 48 SCC, ASC, IA1, IA2, IB1,
Retrospective Others IB2, IIA
17 Mendivil, 2015 USA Cohort 136 97 39 48.3 SCC, ACC, ASC, IA2, IB1, IB2,
Retrospective Others IIA
18 Nam, 2012 Korea Cohort 526 263 263 NA SCC, ACC, ASC IA2, IB1, IB2,
Retrospective IIA
19 Uppal, 2020 USA Cohort 785 560 255 NA SCC, ACC, ASC IA1, IA2, IB1
Retrospective
20 Yuan, 2019 China Cohort 198 99 99 44 NA IA2, IB1, IB2,
Retrospective IIA
No Author Country Study Design Total Novel Therapy Conventional Therapy
Population Total Type Dosage Total Type Dosage
1 Abbas, 2018 Egypt Randomized Control Trial 187 93 Ferrous Bisglycinate 1x200mg 94 Ferrous Sulphate 1x500mg
2 Bumrungpert, Switzerland Randomized Control Trial 120 55 Ferrous Bisglycinate 1x120mg 53 Ferrous Fumarte 1x200mg
2022
3 Chavan, 2021 India Randomized Control Trial 150 50 IPC 1x100mg 50 Ferrous Sulphate 2x60mg
50 Ferrous Ascorbate 1x100mg
4 Lagana, 2018 Italy Randomized Control Trial 50 25 MDFP-AL 1x30mg 25 Ferrous Gluconate 1x80mg
5 Nappi, 2009 Italy Randomized Control Trial 97 49 Lactoferrin 2x100mg 48 Ferrous Sulphate 1x100mg
6 Rezk, 2016 Egypt Randomized Control Trial 200 100 Lactoferrin 1x250mg 100 Ferrous Sulphate 1x150mg
7 Moety, 2017 Egypt Randomized Control Trial 150 75 Iron Amino Acid 1x15mg 75 Ferrous Fumarate 1x200mg
8 Ahmed, 2022 Bangladesh Cohort Prospective 160 80 Carbonyl Iron 2x50mg 80 Ferrous Sulphate 2x150mg
9 Aly, 2016 Egypt Randomized Control Trial 50 25 IPC 1x200mg 25 Ferrous Sulphate 2x100mg
10 Elkhouly, 2022 Egypt Randomized Control Trial 115 37 Ferrous Bisglycinate 1x100mg 38 Ferrous Fumarate 1x100mg
40 IPC 1x100mg
11 Elnory, 2018 Egypt Randomized Control Trial 310 115 IPC 1x100mg 115 Ferrous Sulphate 1x100mg
12 Elsenity, 2018 Egypt Randomized Control Trial 290 145 IPC NA 146 Ferrous Sulphate 1x60mg
13 Gamad, 2021 India Randomized Control Trial 126 27 Ferrous Ascorbate 2x100mg 27 Ferrous Sulphate 2x300mg
25 Carbonyl Iron 4x50mg 27 Ferrous Fumarate 1x200mg
14 Ortiz, 2011 Colombia Randomized Control Trial 80 41 IPC 2x100mg 39 Ferrous Sulphate 2x100mg
15 Patil, 2013 India Cohort Prospective 60 20 Ferrous Bisglycinate 1x100mg 20 Ferrous Fumarate 1x100mg
20 Carbonyl Iron 1x100mg
16 Rateb, 2018 Egypt Randomized Control Trial 188 95 Lactoferrin 3x150mg 93 Ferrous Sulphate 2x100mg
17 Singhal, 2015 India Randomized Control Trial 250 50 Ferrous Bisglycinate 1x30mg 50 Ferrous Sulphate 1x100mg
50 Sodium Feredate 1x33mg 50 Ferrous Fumarate 1x100mg
50 Ferrous Ascorbate 1x100mg
18 Youssef, 2014 Egypt Cohort Prospective 300 100 Ferrous Bisglycinate 3x66mg 100 Ferrous Fumarate 1x100mg
100 Amino Acid Chelate 1x27mg
19 Saka, 2007 India Randomized Control Trial 100 48 IPC 2x100mg 52 Ferrous Sulphate 2x100mg